product summary
company name :
BD Biosciences
other brands :
Transduction Laboratories, PharMingen, Difco
product type :
antibody
product name :
p130 Cas
catalog :
610271
quantity :
50 µg
price :
207.00 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
21/p130[Cas
reactivity :
human, mouse, rat, dogs, chicken
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, western blot knockout validation
more info or order :
citations: 11
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; human; loading ...; fig s5a
  • western blot knockout validation; mouse; loading ...; fig 2a
  • immunohistochemistry - paraffin section; mouse; loading ...; fig s3b
  • immunocytochemistry; mouse; loading ...; fig 1d
Miyazaki T, Zhao Z, Ichihara Y, Yoshino D, Imamura T, Sawada K, et al. Mechanical regulation of bone homeostasis through p130Cas-mediated alleviation of NF-κB activity. Sci Adv. 2019;5:eaau7802 pubmed publisher
  • western blot; human; loading ...; fig 2a
Frank S, Köllmann C, van Lidth de Jeude J, Thiagarajah J, Engelholm L, Frödin M, et al. The focal adhesion-associated proteins DOCK5 and GIT2 comprise a rheostat in control of epithelial invasion. Oncogene. 2017;36:1816-1828 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 5f
  • western blot; human; loading ...; fig 5a
Kumar B, Dutta D, Iqbal J, Ansari M, Roy A, Chikoti L, et al. ESCRT-I Protein Tsg101 Plays a Role in the Post-macropinocytic Trafficking and Infection of Endothelial Cells by Kaposi's Sarcoma-Associated Herpesvirus. PLoS Pathog. 2016;12:e1005960 pubmed publisher
  • western blot; human
Eucker T, Samuelson D, Hunzicker Dunn M, Konkel M. The focal complex of epithelial cells provides a signalling platform for interleukin-8 induction in response to bacterial pathogens. Cell Microbiol. 2014;16:1441-55 pubmed publisher
Kessler B, Mishall K, Kellett M, Clark E, Pugazhenthi U, Pozdeyev N, et al. Resistance to Src inhibition alters the BRAF-mutant tumor secretome to promote an invasive phenotype and therapeutic escape through a FAK>p130Cas>c-Jun signaling axis. Oncogene. 2019;38:2565-2579 pubmed publisher
Roelants C, Giacosa S, Pillet C, Bussat R, Champelovier P, Bastien O, et al. Combined inhibition of PI3K and Src kinases demonstrates synergistic therapeutic efficacy in clear-cell renal carcinoma. Oncotarget. 2018;9:30066-30078 pubmed publisher
Ellison T, Atkinson S, Steri V, Kirkup B, Preedy M, Johnson R, et al. Suppression of β3-integrin in mice triggers a neuropilin-1-dependent change in focal adhesion remodelling that can be targeted to block pathological angiogenesis. Dis Model Mech. 2015;8:1105-19 pubmed publisher
Gomez G, McLachlan R, Wu S, Caldwell B, Moussa E, Verma S, et al. An RPTPα/Src family kinase/Rap1 signaling module recruits myosin IIB to support contractile tension at apical E-cadherin junctions. Mol Biol Cell. 2015;26:1249-62 pubmed publisher
Ambjørn M, Dubreuil V, Miozzo F, Nigon F, Møller B, Issazadeh Navikas S, et al. A loss-of-function screen for phosphatases that regulate neurite outgrowth identifies PTPN12 as a negative regulator of TrkB tyrosine phosphorylation. PLoS ONE. 2013;8:e65371 pubmed publisher
Lahlou H, Sanguin Gendreau V, Frame M, Muller W. Focal adhesion kinase contributes to proliferative potential of ErbB2 mammary tumour cells but is dispensable for ErbB2 mammary tumour induction in vivo. Breast Cancer Res. 2012;14:R36 pubmed
Near R, Smith R, Toselli P, Freddo T, Bloom A, Vanden Borre P, et al. Loss of AND-34/BCAR3 expression in mice results in rupture of the adult lens. Mol Vis. 2009;15:685-99 pubmed
product information
Cat.# :
610271
Brand :
BD Transduction Laboratories
Name :
p130 Cas
Format :
Purified
Clone :
21/p130[Cas
Isotype :
Ms IgG 1
React :
Hu , Ms , Rat , Dog , Chick
Conc :
250 µg/ml
Apps :
IF , IHC(F)* , IP , WB
Size :
50 µg
Status :
RUO
List Price :
207.00 USD
more info or order :
company information