product summary
company name :
BD Biosciences
other brands :
Transduction Laboratories, PharMingen, Difco
product type :
antibody
product name :
eIF-4E
catalog :
610269
quantity :
50 µg
price :
207.00 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
87/eIF-4E
reactivity :
human, mouse, rat, dog, chicken
application :
western blot, immunohistochemistry - frozen section
more info or order :
citations: 15
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; 1:1000; loading ...; fig s3d
Zhu P, Khatiwada S, Cui Y, Reineke L, Dooling S, Kim J, et al. Activation of the ISR mediates the behavioral and neurophysiological abnormalities in Down syndrome. Science. 2019;366:843-849 pubmed publisher
  • western blot; human; loading ...; fig 1e
Zhan Y, Guo J, Yang W, Goncalves C, Rzymski T, Dreas A, et al. MNK1/2 inhibition limits oncogenicity and metastasis of KIT-mutant melanoma. J Clin Invest. 2017;127:4179-4192 pubmed publisher
  • immunohistochemistry - frozen section; rat; loading ...; fig 2a
  • western blot; rat; loading ...; fig 8a
Ayuso M, Martínez Alonso E, Regidor I, Alcazar A. Stress Granule Induction after Brain Ischemia Is Independent of Eukaryotic Translation Initiation Factor (eIF) 2? Phosphorylation and Is Correlated with a Decrease in eIF4B and eIF4E Proteins. J Biol Chem. 2016;291:27252-27264 pubmed publisher
  • western blot; human; 1:1000; fig s3
Gandin V, Masvidal L, Cargnello M, Gyenis L, McLaughlan S, Cai Y, et al. mTORC1 and CK2 coordinate ternary and eIF4F complex assembly. Nat Commun. 2016;7:11127 pubmed publisher
  • western blot; mouse; 1:1000; fig 2
Khoutorsky A, Bonin R, Sorge R, Gkogkas C, Pawlowski S, Jafarnejad S, et al. Translational control of nociception via 4E-binding protein 1. elife. 2015;4: pubmed publisher
  • western blot; human; fig 13a
Fonseca B, Zakaria C, Jia J, Graber T, Svitkin Y, Tahmasebi S, et al. La-related Protein 1 (LARP1) Represses Terminal Oligopyrimidine (TOP) mRNA Translation Downstream of mTOR Complex 1 (mTORC1). J Biol Chem. 2015;290:15996-6020 pubmed publisher
  • western blot; human; 1:1000; fig 1
Malikov V, da Silva E, Jovasevic V, Bennett G, de Souza Aranha Vieira D, Schulte B, et al. HIV-1 capsids bind and exploit the kinesin-1 adaptor FEZ1 for inward movement to the nucleus. Nat Commun. 2015;6:6660 pubmed publisher
Yan S, Um S, Peek V, Stephens J, Zeng W, Konicek B, et al. MET-targeting antibody (emibetuzumab) and kinase inhibitor (merestinib) as single agent or in combination in a cancer model bearing MET exon 14 skipping. Invest New Drugs. 2018;36:536-544 pubmed publisher
Delaney M, Malikov V, Chai Q, Zhao G, Naghavi M. Distinct functions of diaphanous-related formins regulate HIV-1 uncoating and transport. Proc Natl Acad Sci U S A. 2017;114:E6932-E6941 pubmed publisher
Ayuso M, Martínez Alonso E, Salvador N, Bonova P, Regidor I, Alcázar A. Dissociation of eIF4E-binding protein 2 (4E-BP2) from eIF4E independent of Thr37/Thr46 phosphorylation in the ischemic stress response. PLoS ONE. 2015;10:e0121958 pubmed publisher
Mahalingam P, Takrouri K, Chen T, Sahoo R, Papadopoulos E, Chen L, et al. Synthesis of rigidified eIF4E/eIF4G inhibitor-1 (4EGI-1) mimetic and their in vitro characterization as inhibitors of protein-protein interaction. J Med Chem. 2014;57:5094-111 pubmed publisher
Huot G, Vernier M, Bourdeau V, Doucet L, Saint Germain E, Gaumont Leclerc M, et al. CHES1/FOXN3 regulates cell proliferation by repressing PIM2 and protein biosynthesis. Mol Biol Cell. 2014;25:554-65 pubmed publisher
Arias C, Walsh D, Harbell J, Wilson A, Mohr I. Activation of host translational control pathways by a viral developmental switch. PLoS Pathog. 2009;5:e1000334 pubmed publisher
Dobson T, Kube E, Timmerman S, Krushel L. Identifying intrinsic and extrinsic determinants that regulate internal initiation of translation mediated by the FMR1 5' leader. BMC Mol Biol. 2008;9:89 pubmed publisher
Wiesenthal V, Leutz A, Calkhoven C. A translation control reporter system (TCRS) for the analysis of translationally controlled processes in the vertebrate cell. Nucleic Acids Res. 2006;34:e23 pubmed
product information
Cat.# :
610269
Brand :
BD Transduction Laboratories
Name :
eIF-4E
Format :
Purified
Clone :
87/eIF-4E
Isotype :
Ms IgG 1
React :
Hu , Ms , Rat , Dog , Chick , Frog
Conc :
250 µg/ml
Apps :
Bioimg , WB
Size :
50 µg
Status :
RUO
List Price :
207.00 USD
more info or order :
company information