Published Application/Species/Sample/Dilution | Reference |
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- western blot knockout validation; rat; 1:1000; loading ...; fig s1d
| Ding L, Shunkwiler L, Harper N, Zhao Y, Hinohara K, Huh S, et al. Deletion of Cdkn1b in ACI rats leads to increased proliferation and pregnancy-associated changes in the mammary gland due to perturbed systemic endocrine environment. PLoS Genet. 2019;15:e1008002 pubmed publisher
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- immunohistochemistry; mouse; loading ...; fig s4c
| Walter D, Yates T, Ruiz Torres M, Kim Kiselak C, Gudiel A, Deshpande C, et al. RB constrains lineage fidelity and multiple stages of tumour progression and metastasis. Nature. 2019;569:423-427 pubmed publisher
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- immunohistochemistry; mouse; 1:500; loading ...; fig 3b
| Lawton A, Engstrom T, Rohrbach D, Omura M, Turnbull D, Mamou J, et al. Cerebellar folding is initiated by mechanical constraints on a fluid-like layer without a cellular pre-pattern. elife. 2019;8: pubmed publisher
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- immunohistochemistry; mouse; loading ...; fig 2c
| Chen X, Chanda A, Ikeuchi Y, Zhang X, Goodman J, Reddy N, et al. The Transcriptional Regulator SnoN Promotes the Proliferation of Cerebellar Granule Neuron Precursors in the Postnatal Mouse Brain. J Neurosci. 2019;39:44-62 pubmed publisher
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- western blot; human; loading ...; fig 2c
| Juhasz A, Markel S, Gaur S, Liu H, Lu J, Jiang G, et al. NADPH oxidase 1 supports proliferation of colon cancer cells by modulating reactive oxygen species-dependent signal transduction. J Biol Chem. 2017;292:7866-7887 pubmed publisher
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- immunohistochemistry - paraffin section; mouse; 1:500; loading ...; fig 1d
- immunocytochemistry; mouse; 1:500; fig s8b
| Feng W, Kawauchi D, Körkel Qu H, Deng H, Serger E, Sieber L, et al. Chd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programme. Nat Commun. 2017;8:14758 pubmed publisher
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- immunohistochemistry - paraffin section; mouse; 1:50; loading ...
| Brocks T, Fedorchenko O, Schliermann N, Stein A, Moll U, Seegobin S, et al. Macrophage migration inhibitory factor protects from nonmelanoma epidermal tumors by regulating the number of antigen-presenting cells in skin. FASEB J. 2017;31:526-543 pubmed publisher
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- western blot; mouse; 1:500; loading ...; fig 9a
| Fujimura K, Mitsuhashi T, Shibata S, Shimozato S, Takahashi T. In Utero Exposure to Valproic Acid Induces Neocortical Dysgenesis via Dysregulation of Neural Progenitor Cell Proliferation/Differentiation. J Neurosci. 2016;36:10908-10919 pubmed
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- western blot; human; 1:1000; loading ...; fig 3d
| Qi D, Cobrinik D. MDM2 but not MDM4 promotes retinoblastoma cell proliferation through p53-independent regulation of MYCN translation. Oncogene. 2017;36:1760-1769 pubmed publisher
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- western blot; human; 1:2000; loading ...; fig 2c
| Xue C, Yu D, Gherardi S, Koach J, Milazzo G, Gamble L, et al. MYCN promotes neuroblastoma malignancy by establishing a regulatory circuit with transcription factor AP4. Oncotarget. 2016;7:54937-54951 pubmed publisher
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- immunohistochemistry - paraffin section; human; 1:1000; tbl 3
| Frohwitter G, Buerger H, van Diest P, Korsching E, Kleinheinz J, Fillies T. Cytokeratin and protein expression patterns in squamous cell carcinoma of the oral cavity provide evidence for two distinct pathogenetic pathways. Oncol Lett. 2016;12:107-113 pubmed
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- western blot; human; fig S1B
| Ding X, Jiang W, Zhou P, Liu L, Wan X, Yuan X, et al. Mixed Lineage Leukemia 5 (MLL5) Protein Stability Is Cooperatively Regulated by O-GlcNac Transferase (OGT) and Ubiquitin Specific Protease 7 (USP7). PLoS ONE. 2015;10:e0145023 pubmed publisher
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- immunohistochemistry - frozen section; mouse; fig 1
- western blot; mouse; 1:2000; fig 1
- western blot; human; 1:2000; fig 4
| Lyu L, Whitcomb E, Jiang S, Chang M, Gu Y, Duncan M, et al. Unfolded-protein response-associated stabilization of p27(Cdkn1b) interferes with lens fiber cell denucleation, leading to cataract. FASEB J. 2016;30:1087-95 pubmed publisher
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- western blot; human; 1:1000; fig 1
| Qin J, Zhou Z, Chen W, Wang C, Zhang H, Ge G, et al. BAP1 promotes breast cancer cell proliferation and metastasis by deubiquitinating KLF5. Nat Commun. 2015;6:8471 pubmed publisher
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- western blot; human; 1:500; fig 1
| Ge F, Chen W, Qin J, Zhou Z, Liu R, Liu L, et al. Ataxin-3 like (ATXN3L), a member of the Josephin family of deubiquitinating enzymes, promotes breast cancer proliferation by deubiquitinating Krüppel-like factor 5 (KLF5). Oncotarget. 2015;6:21369-78 pubmed
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- western blot; human; fig 1
| Wang C, Nie Z, Zhou Z, Zhang H, Liu R, Wu J, et al. The interplay between TEAD4 and KLF5 promotes breast cancer partially through inhibiting the transcription of p27Kip1. Oncotarget. 2015;6:17685-97 pubmed
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- western blot; human; 1:1000
| Xu D, Li C, Zhang X, Gong Z, Chan C, Lee S, et al. Skp2-macroH2A1-CDK8 axis orchestrates G2/M transition and tumorigenesis. Nat Commun. 2015;6:6641 pubmed publisher
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- western blot; human; fig 2
| Vogel C, Smit M, Maddalo G, Possik P, Sparidans R, van der Burg S, et al. Cooperative induction of apoptosis in NRAS mutant melanoma by inhibition of MEK and ROCK. Pigment Cell Melanoma Res. 2015;28:307-17 pubmed publisher
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- immunohistochemistry; mouse; 1:300
| Urness L, Wang X, Shibata S, Ohyama T, Mansour S. Fgf10 is required for specification of non-sensory regions of the cochlear epithelium. Dev Biol. 2015;400:59-71 pubmed publisher
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| Chen J, Shin J, Zhao R, Phan L, Wang H, Xue Y, et al. CSN6 drives carcinogenesis by positively regulating Myc stability. Nat Commun. 2014;5:5384 pubmed publisher
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| Perry M, Dufour C, Eichner L, Tsang D, Deblois G, Muller W, et al. ERBB2 deficiency alters an E2F-1-dependent adaptive stress response and leads to cardiac dysfunction. Mol Cell Biol. 2014;34:4232-43 pubmed publisher
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- western blot; mouse; 1:1000; fig 8
| Nishimura Y, Shikanai M, Hoshino M, Ohshima T, Nabeshima Y, Mizutani K, et al. Cdk5 and its substrates, Dcx and p27kip1, regulate cytoplasmic dilation formation and nuclear elongation in migrating neurons. Development. 2014;141:3540-50 pubmed publisher
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| Wojdyla L, Stone A, Sethakorn N, Uppada S, Devito J, Bissonnette M, et al. T-oligo as an anticancer agent in colorectal cancer. Biochem Biophys Res Commun. 2014;446:596-601 pubmed publisher
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- western blot; human; 1:1000
| Kim J, Kim H, Park J, Park D, Cho Y, Sohn C, et al. Epidermal growth factor upregulates Skp2/Cks1 and p27(kip1) in human extrahepatic cholangiocarcinoma cells. World J Gastroenterol. 2014;20:755-73 pubmed publisher
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| Fiori M, Barbini C, Haas T, Marroncelli N, Patrizii M, Biffoni M, et al. Antitumor effect of miR-197 targeting in p53 wild-type lung cancer. Cell Death Differ. 2014;21:774-82 pubmed publisher
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| van Boxtel R, Gomez Puerto C, Mokry M, Eijkelenboom A, van der Vos K, Nieuwenhuis E, et al. FOXP1 acts through a negative feedback loop to suppress FOXO-induced apoptosis. Cell Death Differ. 2013;20:1219-29 pubmed publisher
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- immunohistochemistry - frozen section; chicken; 1:200
| Shirazi Fard S, Jarrin M, Boije H, Fillon V, All Eriksson C, Hallböök F. Heterogenic final cell cycle by chicken retinal Lim1 horizontal progenitor cells leads to heteroploid cells with a remaining replicated genome. PLoS ONE. 2013;8:e59133 pubmed publisher
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| Caldon C, Sergio C, Burgess A, Deans A, Sutherland R, Musgrove E. Cyclin E2 induces genomic instability by mechanisms distinct from cyclin E1. Cell Cycle. 2013;12:606-17 pubmed publisher
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- western blot; human; fig 7
| Macia A, Gallel P, Vaquero M, Gou Fabregas M, Santacana M, Maliszewska A, et al. Sprouty1 is a candidate tumor-suppressor gene in medullary thyroid carcinoma. Oncogene. 2012;31:3961-72 pubmed publisher
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| Inaki M, Kato D, Utsugi T, Onoda F, Hanaoka F, Murakami Y. Genetic analyses using a mouse cell cycle mutant identifies magoh as a novel gene involved in Cdk regulation. Genes Cells. 2011;16:166-78 pubmed publisher
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- western blot; mouse; 1:500
| Martín Ibáñez R, Crespo E, Urbán N, Sergent Tanguy S, Herranz C, Jaumot M, et al. Ikaros-1 couples cell cycle arrest of late striatal precursors with neurogenesis of enkephalinergic neurons. J Comp Neurol. 2010;518:329-51 pubmed publisher
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| Sahin O, Frohlich H, Löbke C, Korf U, Burmester S, Majety M, et al. Modeling ERBB receptor-regulated G1/S transition to find novel targets for de novo trastuzumab resistance. BMC Syst Biol. 2009;3:1 pubmed publisher
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- immunohistochemistry - frozen section; mouse; 1:100
| Poche R, Furuta Y, Chaboissier M, Schedl A, Behringer R. Sox9 is expressed in mouse multipotent retinal progenitor cells and functions in Müller glial cell development. J Comp Neurol. 2008;510:237-50 pubmed publisher
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- immunohistochemistry; mouse; 1:200
| Elshatory Y, Deng M, Xie X, Gan L. Expression of the LIM-homeodomain protein Isl1 in the developing and mature mouse retina. J Comp Neurol. 2007;503:182-97 pubmed
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| Chew E, Hagen T. Substrate-mediated regulation of cullin neddylation. J Biol Chem. 2007;282:17032-40 pubmed
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| Ng M, Gan Y, Hagen T. Characterisation of cellular effects of Burkholderia pseudomallei cycle inhibiting factor (Cif). Biol Open. 2018;7: pubmed publisher
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| Siddam A, Gautier Courteille C, Perez Campos L, Anand D, Kakrana A, Dang C, et al. The RNA-binding protein Celf1 post-transcriptionally regulates p27Kip1 and Dnase2b to control fiber cell nuclear degradation in lens development. PLoS Genet. 2018;14:e1007278 pubmed publisher
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| Mikamo M, Kitagawa K, Sakai S, Uchida C, Ohhata T, Nishimoto K, et al. Inhibiting Skp2 E3 Ligase Suppresses Bleomycin-Induced Pulmonary Fibrosis. Int J Mol Sci. 2018;19: pubmed publisher
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| Bohn J, Van Etten J, Schagat T, Bowman B, McEachin R, Freddolino P, et al. Identification of diverse target RNAs that are functionally regulated by human Pumilio proteins. Nucleic Acids Res. 2018;46:362-386 pubmed publisher
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| Grey W, Ivey A, Milne T, Haferlach T, Grimwade D, Uhlmann F, et al. The Cks1/Cks2 axis fine-tunes Mll1 expression and is crucial for MLL-rearranged leukaemia cell viability. Biochim Biophys Acta Mol Cell Res. 2018;1865:105-116 pubmed publisher
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| Srivastava S, Mohibi S, Mirza S, Band H, Band V. Epidermal Growth Factor Receptor activation promotes ADA3 acetylation through the AKT-p300 pathway. Cell Cycle. 2017;16:1515-1525 pubmed publisher
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| Iida Y, Ciechanover A, Marzese D, Hata K, Bustos M, Ono S, et al. Epigenetic Regulation of KPC1 Ubiquitin Ligase Affects the NF-?B Pathway in Melanoma. Clin Cancer Res. 2017;23:4831-4842 pubmed publisher
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| Griffin N, Sharma G, Zhao X, Mirza S, Srivastava S, Dave B, et al. ADA3 regulates normal and tumor mammary epithelial cell proliferation through c-MYC. Breast Cancer Res. 2016;18:113 pubmed
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| Gómez Puerto M, Verhagen L, Braat A, Lam E, Coffer P, Lorenowicz M. Activation of autophagy by FOXO3 regulates redox homeostasis during osteogenic differentiation. Autophagy. 2016;12:1804-1816 pubmed
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| Moura D, Fernández I, MarÃn Royo G, López Sánchez I, MartÃn Doncel E, Vega F, et al. Oncogenic Sox2 regulates and cooperates with VRK1 in cell cycle progression and differentiation. Sci Rep. 2016;6:28532 pubmed publisher
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| Li L, Grausam K, Wang J, Lun M, Ohli J, Lidov H, et al. Sonic Hedgehog promotes proliferation of Notch-dependent monociliated choroid plexus tumour cells. Nat Cell Biol. 2016;18:418-30 pubmed publisher
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| Hatori Y, Yan Y, Schmidt K, Furukawa E, Hasan N, Yang N, et al. Neuronal differentiation is associated with a redox-regulated increase of copper flow to the secretory pathway. Nat Commun. 2016;7:10640 pubmed publisher
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| Jiang Q, Cheng K, Mei X, Qiu J, Zhang W, Xue Y, et al. Synergistic anticancer effects of triptolide and celastrol, two main compounds from thunder god vine. Oncotarget. 2015;6:32790-804 pubmed publisher
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| Panopoulos A, Pacios Bras C, Choi J, Yenjerla M, Sussman M, Fotedar R, et al. Failure of cell cleavage induces senescence in tetraploid primary cells. Mol Biol Cell. 2014;25:3105-18 pubmed publisher
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| Vorpahl M, Schönhofer Merl S, Michaelis C, Flotho A, Melchior F, Wessely R. The Ran GTPase-activating protein (RanGAP1) is critically involved in smooth muscle cell differentiation, proliferation and migration following vascular injury: implications for neointima formation and restenosis. PLoS ONE. 2014;9:e101519 pubmed publisher
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| Federico A, Forzati F, Esposito F, Arra C, Palma G, Barbieri A, et al. Hmga1/Hmga2 double knock-out mice display a "superpygmy" phenotype. Biol Open. 2014;3:372-8 pubmed publisher
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| Zhang X, Fryknäs M, Hernlund E, Fayad W, De Milito A, Olofsson M, et al. Induction of mitochondrial dysfunction as a strategy for targeting tumour cells in metabolically compromised microenvironments. Nat Commun. 2014;5:3295 pubmed publisher
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| Cavalheiro G, Matos Rodrigues G, Gomes A, Rodrigues P, Martins R. c-Myc regulates cell proliferation during lens development. PLoS ONE. 2014;9:e87182 pubmed publisher
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| Vitale N, Kisslinger A, Paladino S, Procaccini C, Matarese G, Pierantoni G, et al. Resveratrol couples apoptosis with autophagy in UVB-irradiated HaCaT cells. PLoS ONE. 2013;8:e80728 pubmed publisher
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| Kullmann M, Grubbauer C, Goetsch K, Jakel H, Podmirseg S, Trockenbacher A, et al. The p27-Skp2 axis mediates glucocorticoid-induced cell cycle arrest in T-lymphoma cells. Cell Cycle. 2013;12:2625-35 pubmed publisher
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| Tan C, Hagen T. mTORC1 dependent regulation of REDD1 protein stability. PLoS ONE. 2013;8:e63970 pubmed publisher
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| Ring H, Mendu S, Shirazi Fard S, Birnir B, Hallböök F. GABA maintains the proliferation of progenitors in the developing chick ciliary marginal zone and non-pigmented ciliary epithelium. PLoS ONE. 2012;7:e36874 pubmed publisher
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| Loponen H, Ylikoski J, Albrecht J, Pirvola U. Restrictions in cell cycle progression of adult vestibular supporting cells in response to ectopic cyclin D1 expression. PLoS ONE. 2011;6:e27360 pubmed publisher
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| Basile K, Abel E, Aplin A. Adaptive upregulation of FOXD3 and resistance to PLX4032/4720-induced cell death in mutant B-RAF melanoma cells. Oncogene. 2012;31:2471-9 pubmed publisher
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| Chua Y, Boh B, Ponyeam W, Hagen T. Regulation of cullin RING E3 ubiquitin ligases by CAND1 in vivo. PLoS ONE. 2011;6:e16071 pubmed publisher
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| Rico Bautista E, Yang C, Lu L, Roth G, Wolf D. Chemical genetics approach to restoring p27Kip1 reveals novel compounds with antiproliferative activity in prostate cancer cells. BMC Biol. 2010;8:153 pubmed publisher
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| Xu B, Gerin I, Miao H, Vu Phan D, Johnson C, Xu R, et al. Multiple roles for the non-coding RNA SRA in regulation of adipogenesis and insulin sensitivity. PLoS ONE. 2010;5:e14199 pubmed publisher
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| Guo Z, Packard A, Krolewski R, Harris M, Manglapus G, Schwob J. Expression of pax6 and sox2 in adult olfactory epithelium. J Comp Neurol. 2010;518:4395-418 pubmed publisher
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| Pajalunga D, Puggioni E, Mazzola A, Leva V, Montecucco A, Crescenzi M. DNA replication is intrinsically hindered in terminally differentiated myotubes. PLoS ONE. 2010;5:e11559 pubmed publisher
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| Bossuyt W, Kazanjian A, De Geest N, Van Kelst S, De Hertogh G, Geboes K, et al. Atonal homolog 1 is a tumor suppressor gene. PLoS Biol. 2009;7:e39 pubmed publisher
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| Mercatelli N, Coppola V, Bonci D, Miele F, Costantini A, Guadagnoli M, et al. The inhibition of the highly expressed miR-221 and miR-222 impairs the growth of prostate carcinoma xenografts in mice. PLoS ONE. 2008;3:e4029 pubmed publisher
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| Musgrove E, Sergio C, Loi S, Inman C, Anderson L, Alles M, et al. Identification of functional networks of estrogen- and c-Myc-responsive genes and their relationship to response to tamoxifen therapy in breast cancer. PLoS ONE. 2008;3:e2987 pubmed publisher
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