product summary
company name :
BD Biosciences
other brands :
Transduction Laboratories, PharMingen, Difco
product type :
antibody
product name :
Catenin
catalog :
610154
quantity :
150 µg
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
14/Beta-Catenin
reactivity :
human, mouse, rat, dogs, bovine, pigs , zebrafish
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, chromatin immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, other, western blot knockout validation, immunohistochemistry knockout validation, immunocytochemistry knockout validation
more info or order :
citations: 260
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry knockout validation; human; 1:1000; fig 2
  • western blot knockout validation; human; 1:1000; fig 2
Liu Z, Hui Y, Shi L, Chen Z, Xu X, Chi L, et al. Efficient CRISPR/Cas9-Mediated Versatile, Predictable, and Donor-Free Gene Knockout in Human Pluripotent Stem Cells. Stem Cell Reports. 2016;7:496-507 pubmed publisher
  • immunohistochemistry knockout validation; mouse; 1:100; fig 3d
Martinez G, Wijesinghe M, Turner K, Abud H, Taketo M, Noda T, et al. Conditional mutations of beta-catenin and APC reveal roles for canonical Wnt signaling in lens differentiation. Invest Ophthalmol Vis Sci. 2009;50:4794-806 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig e1d
  • western blot; mouse; loading ...; fig e1l
da Silva F, Zhang K, Pinson A, Fatti E, Wilsch Bräuninger M, Herbst J, et al. Mitotic WNT signalling orchestrates neurogenesis in the developing neocortex. EMBO J. 2021;40:e108041 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:100; loading ...; fig 6d
Srivastava S, Zhou H, Setia O, Dardik A, Fernandez Hernando C, GOODWIN J. Podocyte Glucocorticoid Receptors Are Essential for Glomerular Endothelial Cell Homeostasis in Diabetes Mellitus. J Am Heart Assoc. 2021;10:e019437 pubmed publisher
  • western blot; human; loading ...; fig 1b
Ryu H, Nam K, Kim H, Song J, Hwang S, Kim J, et al. Discovery of a Novel Triazolopyridine Derivative as a Tankyrase Inhibitor. Int J Mol Sci. 2021;22: pubmed publisher
  • immunoprecipitation; human; 1:1000; loading ...; fig s6c
  • immunocytochemistry; human; 1:500; loading ...; fig s6a
  • immunohistochemistry; human; 1:500; loading ...; fig s7a, s7b
  • western blot; human; 1:1000; loading ...; fig s6c
Kimura H, Sada R, Takada N, Harada A, Doki Y, Eguchi H, et al. The Dickkopf1 and FOXM1 positive feedback loop promotes tumor growth in pancreatic and esophageal cancers. Oncogene. 2021;40:4486-4502 pubmed publisher
  • western blot; human; fig 7b
  • immunohistochemistry; mouse; loading ...; fig 5c
  • western blot; mouse; loading ...; fig 4a
Srivastava S, Zhou H, Setia O, Liu B, Kanasaki K, Koya D, et al. Loss of endothelial glucocorticoid receptor accelerates diabetic nephropathy. Nat Commun. 2021;12:2368 pubmed publisher
  • immunohistochemistry; mouse; 1:50; loading ...
Gudiño V, Pohl S, Billard C, Cammareri P, Bolado A, Aitken S, et al. RAC1B modulates intestinal tumourigenesis via modulation of WNT and EGFR signalling pathways. Nat Commun. 2021;12:2335 pubmed publisher
  • western blot; mouse; 1:3000; loading ...; fig 3j
  • western blot; human; 1:3000; loading ...; fig s2h
Ryu Y, Lee D, Shim J, Park J, Kim Y, Choi S, et al. KY19382, a novel activator of Wnt/β-catenin signalling, promotes hair regrowth and hair follicle neogenesis. Br J Pharmacol. 2021;178:2533-2546 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig s3-2b
Liu Y, Li L, Liu X, Wang Y, Liu L, Peng L, et al. Arginine methylation of SHANK2 by PRMT7 promotes human breast cancer metastasis through activating endosomal FAK signalling. elife. 2020;9: pubmed publisher
  • western blot; mouse; 1:2000; loading ...; fig 1b
Zhao X, Shao P, Gai K, Li F, Shan Q, Xue H. β-catenin and γ-catenin are dispensable for T lymphocytes and AML leukemic stem cells. elife. 2020;9: pubmed publisher
  • immunohistochemistry; human; 1:100; loading ...; fig 1b
Christgen M, Bartels S, van Luttikhuizen J, Bublitz J, Rieger L, Christgen H, et al. E-cadherin to P-cadherin switching in lobular breast cancer with tubular elements. Mod Pathol. 2020;33:2483-2498 pubmed publisher
  • immunohistochemistry; mouse; 1:200; loading ...; fig 1e
Matos I, Asare A, Levorse J, Ouspenskaia T, de la Cruz Racelis J, Schuhmacher L, et al. Progenitors oppositely polarize WNT activators and inhibitors to orchestrate tissue development. elife. 2020;9: pubmed publisher
  • western blot; human; loading ...; fig 3b
Guo C, Ma X, Xing Y, Zheng C, Xu Y, Shan L, et al. Distinct Processing of lncRNAs Contributes to Non-conserved Functions in Stem Cells. Cell. 2020;181:621-636.e22 pubmed publisher
  • western blot; mouse; 1:500; loading ...; fig 4h
Kim K, Shin W, Kang M, Lee S, Kim D, Kang R, et al. Presynaptic PTPσ regulates postsynaptic NMDA receptor function through direct adhesion-independent mechanisms. elife. 2020;9: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 4h, e9r
Tan S, Swathi Y, Tan S, Goh J, Seishima R, Murakami K, et al. AQP5 enriches for stem cells and cancer origins in the distal stomach. Nature. 2020;578:437-443 pubmed publisher
  • western blot; human; 1:5000; loading ...; fig 1c
Chang L, Kim M, Glinka A, Reinhard C, Niehrs C. The tumor suppressor PTPRK promotes ZNRF3 internalization and is required for Wnt inhibition in the Spemann organizer. elife. 2020;9: pubmed publisher
  • western blot; mouse; 1:5000; fig s4c
Jiang M, Kang Y, Sewastianik T, Wang J, Tanton H, Alder K, et al. BCL9 provides multi-cellular communication properties in colorectal cancer by interacting with paraspeckle proteins. Nat Commun. 2020;11:19 pubmed publisher
  • western blot; mouse; 1:2000; loading ...; fig 5s1a
Dos Santos Carvalho S, Moreau M, Hien Y, Garcia M, Aubailly N, Henderson D, et al. Vangl2 acts at the interface between actin and N-cadherin to modulate mammalian neuronal outgrowth. elife. 2020;9: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig s1h
Wang Y, Chiang I, Ohara T, Fujii S, Cheng J, Muegge B, et al. Long-Term Culture Captures Injury-Repair Cycles of Colonic Stem Cells. Cell. 2019;179:1144-1159.e15 pubmed publisher
  • immunohistochemistry; human; 1:200; loading ...; fig 1e
  • western blot; human; 1:1000; loading ...; fig 1c
Matsumoto S, Yamamichi T, Shinzawa K, Kasahara Y, Nojima S, Kodama T, et al. GREB1 induced by Wnt signaling promotes development of hepatoblastoma by suppressing TGFβ signaling. Nat Commun. 2019;10:3882 pubmed publisher
  • immunohistochemistry; mouse; 1:25; loading ...; fig s1d
van de Vlekkert D, Demmers J, Nguyen X, Campos Y, Machado E, Annunziata I, et al. Excessive exosome release is the pathogenic pathway linking a lysosomal deficiency to generalized fibrosis. Sci Adv. 2019;5:eaav3270 pubmed publisher
  • western blot; human; loading ...; fig 6b
Nakanishi M, Mitchell R, Benoit Y, Orlando L, Reid J, Shimada K, et al. Human Pluripotency Is Initiated and Preserved by a Unique Subset of Founder Cells. Cell. 2019;177:910-924.e22 pubmed publisher
  • western blot; mouse; loading ...; fig 1a
Borhani S, Corciulo C, Larrañaga Vera A, Cronstein B. Adenosine A2A receptor (A2AR) activation triggers Akt signaling and enhances nuclear localization of β-catenin in osteoblasts. FASEB J. 2019;33:7555-7562 pubmed publisher
  • immunocytochemistry; human; 1:200; loading ...; fig s1a
  • western blot; human; 1:20,000; loading ...; fig s1b
Massey J, Liu Y, Alvarenga O, Saez T, Schmerer M, Warmflash A. Synergy with TGFβ ligands switches WNT pathway dynamics from transient to sustained during human pluripotent cell differentiation. Proc Natl Acad Sci U S A. 2019;116:4989-4998 pubmed publisher
  • immunoprecipitation; human; loading ...; fig 1b
  • immunohistochemistry; human; loading ...; fig 1e
  • western blot; human; loading ...; fig 1b
Paul D, Islam S, Manne R, Dinesh U, Malonia S, Maity B, et al. F-box protein FBXO16 functions as a tumor suppressor by attenuating nuclear β-catenin function. J Pathol. 2019;248:266-279 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig s5b
Hwang W, Lan H, Cheng W, Huang S, Yang M. Tumor stem-like cell-derived exosomal RNAs prime neutrophils for facilitating tumorigenesis of colon cancer. J Hematol Oncol. 2019;12:10 pubmed publisher
  • immunocytochemistry; mouse; 1:100; loading ...; fig 1e
Li Y, Merkel C, Zeng X, Heier J, Cantrell P, Sun M, et al. The N-cadherin interactome in primary cardiomyocytes as defined using quantitative proximity proteomics. J Cell Sci. 2019;132: pubmed publisher
  • immunohistochemistry - frozen section; bovine; loading ...; fig 12a'
Domke L, Franke W. The cell-cell junctions of mammalian testes: II. The lamellar smooth muscle monolayer cells of the peritubular wall are laterally connected by vertical adherens junctions-a novel architectonic cell-cell junction system. Cell Tissue Res. 2019;375:451-482 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 4a, s2h,
Russell J, Lu W, Okabe H, Abrams M, Oertel M, Poddar M, et al. Hepatocyte-Specific β-Catenin Deletion During Severe Liver Injury Provokes Cholangiocytes to Differentiate Into Hepatocytes. Hepatology. 2019;69:742-759 pubmed publisher
  • western blot; mouse; 1:10,000; loading ...; fig 1h
  • western blot; human; 1:10,000; loading ...; fig 1a, 1g, 1h
Ji L, Lu B, Wang Z, Yang Z, Reece Hoyes J, Russ C, et al. Identification of ICAT as an APC Inhibitor, Revealing Wnt-Dependent Inhibition of APC-Axin Interaction. Mol Cell. 2018;72:37-47.e4 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:500-1:1000
  • immunohistochemistry - paraffin section; human; 1:500-1:1000
Rickelt S, Hynes R. Antibodies and methods for immunohistochemistry of extracellular matrix proteins. Matrix Biol. 2018;71-72:10-27 pubmed publisher
  • western blot; human; loading ...; fig 3a
Glaeser K, Urban M, Fenech E, Voloshanenko O, Kranz D, Lari F, et al. ERAD-dependent control of the Wnt secretory factor Evi. EMBO J. 2018;37: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:1000; loading ...; fig 6a
McDonough E, Barrett C, Parang B, Mittal M, Smith J, Bradley A, et al. MTG16 is a tumor suppressor in colitis-associated carcinoma. JCI Insight. 2017;2: pubmed publisher
  • western blot; human; 1:2000; fig 2b
Monteagudo S, Cornelis F, Aznar López C, Yibmantasiri P, Guns L, Carmeliet P, et al. DOT1L safeguards cartilage homeostasis and protects against osteoarthritis. Nat Commun. 2017;8:15889 pubmed publisher
  • immunohistochemistry; mouse; 1:100; fig s4i
Paul A, Chaker Z, Doetsch F. Hypothalamic regulation of regionally distinct adult neural stem cells and neurogenesis. Science. 2017;356:1383-1386 pubmed publisher
  • immunohistochemistry - frozen section; mouse; loading ...; fig 1d
Logan C, Rajakaruna S, Bowen C, Radice G, Robinson M, Menko A. N-cadherin regulates signaling mechanisms required for lens fiber cell elongation and lens morphogenesis. Dev Biol. 2017;428:118-134 pubmed publisher
  • western blot; human; loading ...; fig 3a
Jeong S, Lim S, Schevzov G, Gunning P, Helfman D. Loss of Tpm4.1 leads to disruption of cell-cell adhesions and invasive behavior in breast epithelial cells via increased Rac1 signaling. Oncotarget. 2017;8:33544-33559 pubmed publisher
  • immunocytochemistry; human; 1:100; fig 3b
Keckesova Z, Donaher J, De Cock J, Freinkman E, Lingrell S, Bachovchin D, et al. LACTB is a tumour suppressor that modulates lipid metabolism and cell state. Nature. 2017;543:681-686 pubmed publisher
  • western blot; mouse; 1:2000; loading ...; fig 2d
Ye S, Zhang T, Tong C, Zhou X, He K, Ban Q, et al. Depletion of Tcf3 and Lef1 maintains mouse embryonic stem cell self-renewal. Biol Open. 2017;6:511-517 pubmed publisher
  • immunohistochemistry - paraffin section; human; loading ...; fig s4a
Fumagalli A, Drost J, Suijkerbuijk S, van Boxtel R, de Ligt J, Offerhaus G, et al. Genetic dissection of colorectal cancer progression by orthotopic transplantation of engineered cancer organoids. Proc Natl Acad Sci U S A. 2017;114:E2357-E2364 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 5a
  • western blot; human; 1:1000; loading ...; fig 6c
  • western blot; mouse; 1:1000; fig 4e
Subramaniam M, Cicek M, Pitel K, Bruinsma E, Nelson Holte M, Withers S, et al. TIEG1 modulates ?-catenin sub-cellular localization and enhances Wnt signaling in bone. Nucleic Acids Res. 2017;45:5170-5182 pubmed publisher
  • western blot; mouse; loading ...
Mescher M, Jeong P, Knapp S, Rübsam M, Saynisch M, Kranen M, et al. The epidermal polarity protein Par3 is a non-cell autonomous suppressor of malignant melanoma. J Exp Med. 2017;214:339-358 pubmed publisher
  • immunohistochemistry - paraffin section; dogs; 0.8 ug/ml; fig 4m
Yokoyama N, Ohta H, Kagawa Y, Leela Arporn R, Dermlim A, Nisa K, et al. Expression of apical junction complex proteins in colorectal mucosa of miniature dachshunds with inflammatory colorectal polyps. J Vet Med Sci. 2017;79:456-463 pubmed publisher
  • western blot; human; fig 5b
van Andel H, Ren Z, Koopmans I, Joosten S, Kocemba K, de Lau W, et al. Aberrantly expressed LGR4 empowers Wnt signaling in multiple myeloma by hijacking osteoblast-derived R-spondins. Proc Natl Acad Sci U S A. 2017;114:376-381 pubmed publisher
  • immunocytochemistry; human; 1:500; fig 3-s2b
  • western blot; human; 1:1000; fig 2c
Lebensohn A, Dubey R, Neitzel L, Tacchelly Benites O, Yang E, Marceau C, et al. Comparative genetic screens in human cells reveal new regulatory mechanisms in WNT signaling. elife. 2016;5: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig s4d
Karki R, Man S, Malireddi R, Kesavardhana S, Zhu Q, Burton A, et al. NLRC3 is an inhibitory sensor of PI3K-mTOR pathways in cancer. Nature. 2016;540:583-587 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:500; loading ...; fig 5c
Kim E, Davidson L, Zoh R, Hensel M, Salinas M, Patil B, et al. Rapidly cycling Lgr5+ stem cells are exquisitely sensitive to extrinsic dietary factors that modulate colon cancer risk. Cell Death Dis. 2016;7:e2460 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig 6a
Saha S, Aranda E, Hayakawa Y, Bhanja P, Atay S, Brodin N, et al. Macrophage-derived extracellular vesicle-packaged WNTs rescue intestinal stem cells and enhance survival after radiation injury. Nat Commun. 2016;7:13096 pubmed publisher
  • western blot; dogs; fig 6a
Kim M, Jeong J, Seo J, Kim H, Kim S, Jin W. Dysregulated JAK2 expression by TrkC promotes metastasis potential, and EMT program of metastatic breast cancer. Sci Rep. 2016;6:33899 pubmed publisher
  • western blot; human; 1:500; fig 6
Yao J, Qin L, Miao S, Wang X, Wu X. Overexpression of miR-506 suppresses proliferation and promotes apoptosis of osteosarcoma cells by targeting astrocyte elevated gene-1. Oncol Lett. 2016;12:1840-1848 pubmed
  • immunocytochemistry; human; 1:200; loading ...; fig s1a
Dass R, Sarshad A, Carson B, Feenstra J, Kaur A, Obrdlik A, et al. Wnt5a Signals through DVL1 to Repress Ribosomal DNA Transcription by RNA Polymerase I. PLoS Genet. 2016;12:e1006217 pubmed publisher
  • western blot; human; loading ...; fig 1b
Oh B, Kim S, Lee Y, Hong H, Kim T, Kim S, et al. Twist1-induced epithelial-mesenchymal transition according to microsatellite instability status in colon cancer cells. Oncotarget. 2016;7:57066-57076 pubmed publisher
  • immunocytochemistry; human; 1:100; fig 5
Dorland Y, Malinova T, van Stalborch A, Grieve A, van Geemen D, Jansen N, et al. The F-BAR protein pacsin2 inhibits asymmetric VE-cadherin internalization from tensile adherens junctions. Nat Commun. 2016;7:12210 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:75; fig 2
Campos Y, Qiu X, Gomero E, Wakefield R, Horner L, Brutkowski W, et al. Alix-mediated assembly of the actomyosin-tight junction polarity complex preserves epithelial polarity and epithelial barrier. Nat Commun. 2016;7:11876 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:300; fig 1
Liu S, Barry E, Baron J, Rutherford R, Seabrook M, Bostick R. Effects of supplemental calcium and vitamin D on the APC/β-catenin pathway in the normal colorectal mucosa of colorectal adenoma patients. Mol Carcinog. 2017;56:412-424 pubmed publisher
  • western blot; mouse; fig 1
Nakagawa A, Naito A, Sumida T, Nomura S, Shibamoto M, Higo T, et al. Activation of endothelial β-catenin signaling induces heart failure. Sci Rep. 2016;6:25009 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:400; fig 6
Stewart M, Plante I, Penuela S, Laird D. Loss of Panx1 Impairs Mammary Gland Development at Lactation: Implications for Breast Tumorigenesis. PLoS ONE. 2016;11:e0154162 pubmed publisher
  • chromatin immunoprecipitation; mouse; fig 6
Kumar A, Chalamalasetty R, Kennedy M, Thomas S, Inala S, Garriock R, et al. Zfp703 Is a Wnt/?-Catenin Feedback Suppressor Targeting the ?-Catenin/Tcf1 Complex. Mol Cell Biol. 2016;36:1793-802 pubmed publisher
  • western blot; human; loading ...; fig 2b
Park S, Kim J, Kim N, Yang K, Shim J, Heo K. Estradiol, TGF-?1 and hypoxia promote breast cancer stemness and EMT-mediated breast cancer migration. Oncol Lett. 2016;11:1895-1902 pubmed
  • western blot; human; 1:1000; fig 6
Tögel L, Nightingale R, Chueh A, Jayachandran A, Tran H, Phesse T, et al. Dual Targeting of Bromodomain and Extraterminal Domain Proteins, and WNT or MAPK Signaling, Inhibits c-MYC Expression and Proliferation of Colorectal Cancer Cells. Mol Cancer Ther. 2016;15:1217-26 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 3
Sobecki M, Mrouj K, Camasses A, Parisis N, Nicolas E, Llères D, et al. The cell proliferation antigen Ki-67 organises heterochromatin. elife. 2016;5:e13722 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 4a
Huang L, Mokkapati S, Hu Q, Ruteshouser E, Hicks M, Huff V. Nephron Progenitor But Not Stromal Progenitor Cells Give Rise to Wilms Tumors in Mouse Models with β-Catenin Activation or Wt1 Ablation and Igf2 Upregulation. Neoplasia. 2016;18:71-81 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; fig s10
  • western blot; mouse; fig s7
Beyaz S, Mana M, Roper J, Kedrin D, Saadatpour A, Hong S, et al. High-fat diet enhances stemness and tumorigenicity of intestinal progenitors. Nature. 2016;531:53-8 pubmed publisher
  • western blot; mouse; 1:500; fig 5
Gurnik S, Devraj K, Macas J, Yamaji M, Starke J, Scholz A, et al. Angiopoietin-2-induced blood-brain barrier compromise and increased stroke size are rescued by VE-PTP-dependent restoration of Tie2 signaling. Acta Neuropathol. 2016;131:753-73 pubmed publisher
  • western blot; human; fig 3
Tepper S, Jeschke J, Böttcher K, Schmidt A, Davari K, Müller P, et al. PARP activation promotes nuclear AID accumulation in lymphoma cells. Oncotarget. 2016;7:13197-208 pubmed publisher
  • immunohistochemistry - paraffin section; human; 0.33 mg/ml; fig 4
McCabe M, Tarulli G, Laven Law G, Matthiesson K, Meachem S, McLachlan R, et al. Gonadotropin suppression in men leads to a reduction in claudin-11 at the Sertoli cell tight junction. Hum Reprod. 2016;31:875-86 pubmed publisher
  • immunoprecipitation; human; fig 3d
  • western blot; human; fig 2a
Hwang S, Lee H, Kim H, Lee H, Shin C, Yun S, et al. Ubiquitin-specific protease 4 controls metastatic potential through β-catenin stabilization in brain metastatic lung adenocarcinoma. Sci Rep. 2016;6:21596 pubmed publisher
  • western blot; human; fig 4
Kim D, Helfman D. Loss of MLCK leads to disruption of cell-cell adhesion and invasive behavior of breast epithelial cells via increased expression of EGFR and ERK/JNK signaling. Oncogene. 2016;35:4495-508 pubmed publisher
  • immunocytochemistry; mouse; 10 ug/ml; fig 2
Lazarevic I, Engelhardt B. Modeling immune functions of the mouse blood-cerebrospinal fluid barrier in vitro: primary rather than immortalized mouse choroid plexus epithelial cells are suited to study immune cell migration across this brain barrier. Fluids Barriers CNS. 2016;13:2 pubmed publisher
  • western blot; human; 1:2000; fig 1
Gao Y, Zhao Y, Zhang J, Lu Y, Liu X, Geng P, et al. The dual function of PRMT1 in modulating epithelial-mesenchymal transition and cellular senescence in breast cancer cells through regulation of ZEB1. Sci Rep. 2016;6:19874 pubmed publisher
  • other; human; loading ...; fig st1
Kanderová V, Kuzilkova D, Stuchly J, Vaskova M, Brdicka T, Fiser K, et al. High-resolution Antibody Array Analysis of Childhood Acute Leukemia Cells. Mol Cell Proteomics. 2016;15:1246-61 pubmed publisher
  • immunocytochemistry; dogs; fig s8
  • western blot; dogs; 1:2000; fig 1
Tien S, Lee H, Yang Y, Lin M, Chen Y, Chang Z. The Shp2-induced epithelial disorganization defect is reversed by HDAC6 inhibition independent of Cdc42. Nat Commun. 2016;7:10420 pubmed publisher
  • immunohistochemistry; mouse; 1:500; fig 5
Jimeno D, Gómez C, Calzada N, de la Villa P, Lillo C, Santos E. RASGRF2 controls nuclear migration in postnatal retinal cone photoreceptors. J Cell Sci. 2016;129:729-42 pubmed publisher
  • western blot; human; fig 4c
Chen Y, Statt S, Wu R, Chang H, Liao J, Wang C, et al. High mobility group box 1-induced epithelial mesenchymal transition in human airway epithelial cells. Sci Rep. 2016;6:18815 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; fig 1
Maimets M, Rocchi C, Bron R, Pringle S, Kuipers J, Giepmans B, et al. Long-Term In Vitro Expansion of Salivary Gland Stem Cells Driven by Wnt Signals. Stem Cell Reports. 2016;6:150-62 pubmed publisher
  • immunocytochemistry; mouse; fig 2
  • western blot; mouse; fig 2
Giampietro C, Disanza A, Bravi L, Barrios Rodiles M, Corada M, Frittoli E, et al. The actin-binding protein EPS8 binds VE-cadherin and modulates YAP localization and signaling. J Cell Biol. 2015;211:1177-92 pubmed publisher
  • immunocytochemistry; mouse; 1:100; fig 5
Mills K, Brocardo M, Henderson B. APC binds the Miro/Milton motor complex to stimulate transport of mitochondria to the plasma membrane. Mol Biol Cell. 2016;27:466-82 pubmed publisher
  • western blot; mouse; fig 3
Kühne H, Hause G, Grundmann S, Schutkowski A, Brandsch C, Stangl G. Vitamin D receptor knockout mice exhibit elongated intestinal microvilli and increased ezrin expression. Nutr Res. 2016;36:184-92 pubmed publisher
  • immunocytochemistry; rat; 500 ng/ml; fig 3
McCabe M, Foo C, Dinger M, Smooker P, Stanton P. Claudin-11 and occludin are major contributors to Sertoli cell tight junction function, in vitro. Asian J Androl. 2016;18:620-6 pubmed publisher
  • immunocytochemistry; mouse; 1:100; fig 1d
Koudelkova P, Weber G, Mikulits W. Liver Sinusoidal Endothelial Cells Escape Senescence by Loss of p19ARF. PLoS ONE. 2015;10:e0142134 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200; loading ...; fig 1B
  • western blot; human; 1:1000; loading ...; fig 2A
Pai P, Rachagani S, Lakshmanan I, Macha M, Sheinin Y, Smith L, et al. The canonical Wnt pathway regulates the metastasis-promoting mucin MUC4 in pancreatic ductal adenocarcinoma. Mol Oncol. 2016;10:224-39 pubmed publisher
  • immunocytochemistry; mouse; 1:200; fig s2
  • immunocytochemistry; human; 1:2000; fig 2
  • western blot; human; 1:1000; fig 6
Leal L, Bueno A, Gomes D, Abduch R, de Castro M, Antonini S. Inhibition of the Tcf/beta-catenin complex increases apoptosis and impairs adrenocortical tumor cell proliferation and adrenal steroidogenesis. Oncotarget. 2015;6:43016-32 pubmed publisher
  • western blot; mouse; 1:150; fig 7
Eisses J, Criscimanna A, Dionise Z, Orabi A, Javed T, Sarwar S, et al. Valproic Acid Limits Pancreatic Recovery after Pancreatitis by Inhibiting Histone Deacetylases and Preventing Acinar Redifferentiation Programs. Am J Pathol. 2015;185:3304-15 pubmed publisher
  • chromatin immunoprecipitation; mouse; fig 5
  • immunocytochemistry; mouse; fig 10
  • western blot; mouse; fig 3
Akhade V, Dighe S, Kataruka S, Rao M. Mechanism of Wnt signaling induced down regulation of mrhl long non-coding RNA in mouse spermatogonial cells. Nucleic Acids Res. 2016;44:387-401 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:400; fig 5
Stewart M, Bechberger J, Welch I, Naus C, Laird D. Cx26 knockout predisposes the mammary gland to primary mammary tumors in a DMBA-induced mouse model of breast cancer. Oncotarget. 2015;6:37185-99 pubmed publisher
  • immunocytochemistry; human
Jamieson C, Lui C, Brocardo M, Martino Echarri E, Henderson B. Rac1 augments Wnt signaling by stimulating β-catenin-lymphoid enhancer factor-1 complex assembly independent of β-catenin nuclear import. J Cell Sci. 2015;128:3933-46 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:1000; fig s12c
Mazur P, Herner A, Mello S, Wirth M, Hausmann S, Sánchez Rivera F, et al. Combined inhibition of BET family proteins and histone deacetylases as a potential epigenetics-based therapy for pancreatic ductal adenocarcinoma. Nat Med. 2015;21:1163-71 pubmed publisher
  • chromatin immunoprecipitation; mouse; fig 4f,g
Fong C, Gilan O, Lam E, Rubin A, Ftouni S, Tyler D, et al. BET inhibitor resistance emerges from leukaemia stem cells. Nature. 2015;525:538-42 pubmed publisher
  • immunocytochemistry; human; loading ...; fig 1a
Piccolo E, Tinari N, D Addario D, Rossi C, Iacobelli V, La Sorda R, et al. Prognostic relevance of LGALS3BP in human colorectal carcinoma. J Transl Med. 2015;13:248 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200; loading ...; tbl 2
Takahashi S, Kohashi K, Yamamoto H, Hirahashi M, Kumagai R, Takizawa N, et al. Expression of adhesion molecules and epithelial-mesenchymal transition factors in medullary carcinoma of the colorectum. Hum Pathol. 2015;46:1257-66 pubmed publisher
  • western blot; human; fig 1c
Eiring A, Khorashad J, Anderson D, Yu F, Redwine H, Mason C, et al. β-Catenin is required for intrinsic but not extrinsic BCR-ABL1 kinase-independent resistance to tyrosine kinase inhibitors in chronic myeloid leukemia. Leukemia. 2015;29:2328-37 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; fig 3
Cartón García F, Overeem A, Nieto R, Bazzocco S, Dopeso H, Macaya I, et al. Myo5b knockout mice as a model of microvillus inclusion disease. Sci Rep. 2015;5:12312 pubmed publisher
  • western blot; mouse; 1:100
Wainwright E, Wilhelm D, Combes A, Little M, Koopman P. ROBO2 restricts the nephrogenic field and regulates Wolffian duct-nephrogenic cord separation. Dev Biol. 2015;404:88-102 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 5
Sugiyama Y, Shelley E, Badouel C, McNeill H, McAvoy J. Atypical Cadherin Fat1 Is Required for Lens Epithelial Cell Polarity and Proliferation but Not for Fiber Differentiation. Invest Ophthalmol Vis Sci. 2015;56:4099-107 pubmed publisher
  • western blot; mouse; fig 6
Zhang J, Li L, Baldwin A, Friedman A, Paz Priel I. Loss of IKKβ but Not NF-κB p65 Skews Differentiation towards Myeloid over Erythroid Commitment and Increases Myeloid Progenitor Self-Renewal and Functional Long-Term Hematopoietic Stem Cells. PLoS ONE. 2015;10:e0130441 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:500; fig s2
Scalia C, Gendusa R, Cattoretti G. A 2-Step Laemmli and Antigen Retrieval Method Improves Immunodetection. Appl Immunohistochem Mol Morphol. 2016;24:436-46 pubmed publisher
  • immunohistochemistry; mouse
Williams B, Tebbutt N, Buchert M, Putoczki T, Doggett K, Bao S, et al. Glycoprotein A33 deficiency: a new mouse model of impaired intestinal epithelial barrier function and inflammatory disease. Dis Model Mech. 2015;8:805-15 pubmed publisher
  • western blot; human
Duvall Noelle N, Karwandyar A, Richmond A, Raman D. LASP-1: a nuclear hub for the UHRF1-DNMT1-G9a-Snail1 complex. Oncogene. 2016;35:1122-33 pubmed publisher
  • western blot; human
Vaškovičová K, Szabadosová E, Čermák V, Gandalovičová A, Kasalová L, Rösel D, et al. PKCα promotes the mesenchymal to amoeboid transition and increases cancer cell invasiveness. BMC Cancer. 2015;15:326 pubmed publisher
  • western blot; human; fig 2
Teasley D, Parajuli S, Nguyen M, Moore H, Alspach E, Lock Y, et al. Flap Endonuclease 1 Limits Telomere Fragility on the Leading Strand. J Biol Chem. 2015;290:15133-45 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100; fig 1
Shaikh L, Zhou J, Teo A, Garg S, Neogi S, Figg N, et al. LGR5 Activates Noncanonical Wnt Signaling and Inhibits Aldosterone Production in the Human Adrenal. J Clin Endocrinol Metab. 2015;100:E836-44 pubmed publisher
  • immunocytochemistry; mouse; 1:100
Figeac N, Zammit P. Coordinated action of Axin1 and Axin2 suppresses β-catenin to regulate muscle stem cell function. Cell Signal. 2015;27:1652-65 pubmed publisher
  • western blot; human; 1:1000; fig 5c
Lund K, Dembinski J, Solberg N, Urbanucci A, Mills I, Krauss S. Slug-dependent upregulation of L1CAM is responsible for the increased invasion potential of pancreatic cancer cells following long-term 5-FU treatment. PLoS ONE. 2015;10:e0123684 pubmed publisher
  • western blot; human; 1:2000; fig 1c
Janes K. An analysis of critical factors for quantitative immunoblotting. Sci Signal. 2015;8:rs2 pubmed publisher
  • immunocytochemistry; human; 1:200
Lee J, Garbe J, Vrba L, Miyano M, Futscher B, Stampfer M, et al. Age and the means of bypassing stasis influence the intrinsic subtype of immortalized human mammary epithelial cells. Front Cell Dev Biol. 2015;3:13 pubmed publisher
  • western blot; mouse; 1:500; fig 3
Boersma V, Moatti N, Segura Bayona S, Peuscher M, van der Torre J, Wevers B, et al. MAD2L2 controls DNA repair at telomeres and DNA breaks by inhibiting 5' end resection. Nature. 2015;521:537-540 pubmed publisher
  • immunocytochemistry; pigs ; 1:200
Melo E, Kasper J, Unger R, Farré R, Kirkpatrick C. Development of a Bronchial Wall Model: Triple Culture on a Decellularized Porcine Trachea. Tissue Eng Part C Methods. 2015;21:909-21 pubmed publisher
  • immunohistochemistry; human; 1:100
Geels Y, van der Putten L, van Tilborg A, Lurkin I, Zwarthoff E, Pijnenborg J, et al. Immunohistochemical and genetic profiles of endometrioid endometrial carcinoma arising from atrophic endometrium. Gynecol Oncol. 2015;137:245-51 pubmed publisher
  • immunohistochemistry; human
Wagner R, Luciani F, Cario André M, Rubod A, Petit V, Benzekri L, et al. Altered E-Cadherin Levels and Distribution in Melanocytes Precede Clinical Manifestations of Vitiligo. J Invest Dermatol. 2015;135:1810-1819 pubmed publisher
  • western blot; mouse
Cai K, Wang Y, Smith E, Smedberg J, Yang D, Yang W, et al. Global deletion of Trp53 reverts ovarian tumor phenotype of the germ cell-deficient white spotting variant (Wv) mice. Neoplasia. 2015;17:89-100 pubmed publisher
  • western blot; human; fig s1
Banach Orlowska M, Szymańska E, Miaczynska M. APPL1 endocytic adaptor as a fine tuner of Dvl2-induced transcription. FEBS Lett. 2015;589:532-9 pubmed publisher
  • western blot; human; fig 4
Chow H, Dong B, Duron S, Campbell D, Ong C, Hoeflich K, et al. Group I Paks as therapeutic targets in NF2-deficient meningioma. Oncotarget. 2015;6:1981-94 pubmed
  • other; human; loading ...; fig 3a
  • immunoprecipitation; human; loading ...; fig 7b
  • western blot; human; loading ...; fig 4a
Traenkle B, Emele F, Anton R, Poetz O, Haeussler R, Maier J, et al. Monitoring interactions and dynamics of endogenous beta-catenin with intracellular nanobodies in living cells. Mol Cell Proteomics. 2015;14:707-23 pubmed publisher
  • western blot; human; 1:500; fig s2d
Yokoi N, Fukata Y, Kase D, Miyazaki T, Jaegle M, Ohkawa T, et al. Chemical corrector treatment ameliorates increased seizure susceptibility in a mouse model of familial epilepsy. Nat Med. 2015;21:19-26 pubmed publisher
  • western blot; mouse
Bisson J, Mills B, Paul Helt J, Zwaka T, Cohen E. Wnt5a and Wnt11 inhibit the canonical Wnt pathway and promote cardiac progenitor development via the Caspase-dependent degradation of AKT. Dev Biol. 2015;398:80-96 pubmed publisher
  • immunohistochemistry - paraffin section; mouse
Davis H, Irshad S, Bansal M, Rafferty H, Boitsova T, Bardella C, et al. Aberrant epithelial GREM1 expression initiates colonic tumorigenesis from cells outside the stem cell niche. Nat Med. 2015;21:62-70 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:1000; loading ...; fig 1
Jones R, Abedalthagafi M, Brahmandam M, Greenfield E, Hoang M, Louis D, et al. Cross-reactivity of the BRAF VE1 antibody with epitopes in axonemal dyneins leads to staining of cilia. Mod Pathol. 2015;28:596-606 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:200
  • chromatin immunoprecipitation; human
Isobe T, Hisamori S, Hogan D, Zabala M, Hendrickson D, Dalerba P, et al. miR-142 regulates the tumorigenicity of human breast cancer stem cells through the canonical WNT signaling pathway. elife. 2014;3: pubmed publisher
  • immunohistochemistry; human; 1:400
Voorneveld P, Kodach L, Jacobs R, van Noesel C, Peppelenbosch M, Korkmaz K, et al. The BMP pathway either enhances or inhibits the Wnt pathway depending on the SMAD4 and p53 status in CRC. Br J Cancer. 2015;112:122-30 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100
Raap M, Antonopoulos W, Dämmrich M, Christgen H, Steinmann D, Länger F, et al. High frequency of lobular breast cancer in distant metastases to the orbit. Cancer Med. 2015;4:104-11 pubmed publisher
  • western blot; human
Yu J, Kong C, Zhang Z, Zhan B, Jiang Z. Aplasia Ras homolog member I expression induces apoptosis in renal cancer cells via the β-catenin signaling pathway. Mol Med Rep. 2015;11:475-81 pubmed publisher
  • immunohistochemistry; mouse
Liu C, Lin C, Gao C, May Simera H, Swaroop A, Li T. Null and hypomorph Prickle1 alleles in mice phenocopy human Robinow syndrome and disrupt signaling downstream of Wnt5a. Biol Open. 2014;3:861-70 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:100
Ihara K, Asanuma K, Fukuda T, Ohwada S, Yoshida M, Nishimori K. MAGI-2 is critical for the formation and maintenance of the glomerular filtration barrier in mouse kidney. Am J Pathol. 2014;184:2699-708 pubmed publisher
  • immunohistochemistry; mouse
Zhang S, Li L, Kendrick S, Gerard R, Zhu H. TALEN-mediated somatic mutagenesis in murine models of cancer. Cancer Res. 2014;74:5311-21 pubmed publisher
  • western blot; dogs; fig 1
Ohta H, Sunden Y, Yokoyama N, Osuga T, Lim S, Tamura Y, et al. Expression of apical junction complex proteins in duodenal mucosa of dogs with inflammatory bowel disease. Am J Vet Res. 2014;75:746-51 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:1000
Powell A, Vlacich G, Zhao Z, McKinley E, Washington M, Manning H, et al. Inducible loss of one Apc allele in Lrig1-expressing progenitor cells results in multiple distal colonic tumors with features of familial adenomatous polyposis. Am J Physiol Gastrointest Liver Physiol. 2014;307:G16-23 pubmed publisher
  • western blot; human; 1:1000
Elliott V, Rychahou P, Zaytseva Y, Evers B. Activation of c-Met and upregulation of CD44 expression are associated with the metastatic phenotype in the colorectal cancer liver metastasis model. PLoS ONE. 2014;9:e97432 pubmed publisher
  • western blot; mouse; 1:2000; loading ...; fig 3a
Zhao C, Zhang J, Li K, Yang J, Yu H, Duan S, et al. ?-Catenin regulates membrane potential in muscle cells by regulating the ?2 subunit of Na,K-ATPase. Eur J Neurosci. 2014;40:2216-24 pubmed publisher
  • western blot; mouse
Wang H, Sun W, Ma J, Pan Y, Wang L, Zhang W. Polycystin-1 mediates mechanical strain-induced osteoblastic mechanoresponses via potentiation of intracellular calcium and Akt/?-catenin pathway. PLoS ONE. 2014;9:e91730 pubmed publisher
  • chromatin immunoprecipitation; mouse; 5 ug/time
Konsavage W, Yochum G. The myc 3' wnt-responsive element suppresses colonic tumorigenesis. Mol Cell Biol. 2014;34:1659-69 pubmed publisher
  • immunoprecipitation; human; loading ...; fig st13
  • immunocytochemistry; human; 1:200; loading ...; fig st13
  • western blot; human; 1:1000; loading ...; fig st13
Hwang W, Jiang J, Yang S, Huang T, Lan H, Teng H, et al. MicroRNA-146a directs the symmetric division of Snail-dominant colorectal cancer stem cells. Nat Cell Biol. 2014;16:268-80 pubmed publisher
  • immunoprecipitation; human; 1:2000; loading ...; fig 3g
Piao H, Yuan Y, Wang M, Sun Y, Liang H, Ma L. ?-catenin acts as a tumour suppressor in E-cadherin-negative basal-like breast cancer by inhibiting NF-?B signalling. Nat Cell Biol. 2014;16:245-54 pubmed publisher
  • immunocytochemistry; human
  • western blot; human
Byron A, Randles M, Humphries J, Mironov A, Hamidi H, Harris S, et al. Glomerular cell cross-talk influences composition and assembly of extracellular matrix. J Am Soc Nephrol. 2014;25:953-66 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:1000
Metcalfe C, Kljavin N, Ybarra R, De Sauvage F. Lgr5+ stem cells are indispensable for radiation-induced intestinal regeneration. Cell Stem Cell. 2014;14:149-59 pubmed publisher
  • chromatin immunoprecipitation; human
  • western blot; human; 1:1000
Rennoll S, Konsavage W, Yochum G. Nuclear AXIN2 represses MYC gene expression. Biochem Biophys Res Commun. 2014;443:217-22 pubmed publisher
  • immunohistochemistry; rat
Dawes L, Sugiyama Y, Lovicu F, Harris C, Shelley E, McAvoy J. Interactions between lens epithelial and fiber cells reveal an intrinsic self-assembly mechanism. Dev Biol. 2014;385:291-303 pubmed publisher
  • immunohistochemistry - frozen section; mouse
Whiteman E, Fan S, Harder J, Walton K, Liu C, Soofi A, et al. Crumbs3 is essential for proper epithelial development and viability. Mol Cell Biol. 2014;34:43-56 pubmed publisher
  • immunocytochemistry; human
  • western blot; human
Xavier C, Melikova M, Chuman Y, Uren A, Baljinnyam B, Rubin J. Secreted Frizzled-related protein potentiation versus inhibition of Wnt3a/?-catenin signaling. Cell Signal. 2014;26:94-101 pubmed publisher
  • immunocytochemistry; human
Linch M, Sanz Garcia M, Rosse C, Riou P, Peel N, Madsen C, et al. Regulation of polarized morphogenesis by protein kinase C iota in oncogenic epithelial spheroids. Carcinogenesis. 2014;35:396-406 pubmed publisher
  • immunocytochemistry; dogs; 1:200
Boehlke C, Kotsis F, Buchholz B, Powelske C, Eckardt K, Walz G, et al. Kif3a guides microtubular dynamics, migration and lumen formation of MDCK cells. PLoS ONE. 2013;8:e62165 pubmed publisher
  • western blot; mouse
Zhang J, Twelvetrees A, Lazarus J, Blasier K, Yao X, Inamdar N, et al. Establishing a novel knock-in mouse line for studying neuronal cytoplasmic dynein under normal and pathologic conditions. Cytoskeleton (Hoboken). 2013;70:215-27 pubmed publisher
  • immunoprecipitation; human; 2 ug/time
  • western blot; human; 1:2000; fig 7a
Li Y, Zheng Y, Izumi K, Ishiguro H, Ye B, Li F, et al. Androgen activates ?-catenin signaling in bladder cancer cells. Endocr Relat Cancer. 2013;20:293-304 pubmed publisher
  • western blot; rat
Dawes L, Sugiyama Y, Tanedo A, Lovicu F, McAvoy J. Wnt-frizzled signaling is part of an FGF-induced cascade that promotes lens fiber differentiation. Invest Ophthalmol Vis Sci. 2013;54:1582-90 pubmed publisher
  • immunohistochemistry - paraffin section; rat; 1:1000
Femia A, Dolara P, Salvadori M, Caderni G. Expression of LGR-5, MSI-1 and DCAMKL-1, putative stem cell markers, in the early phases of 1,2-dimethylhydrazine-induced rat colon carcinogenesis: correlation with nuclear ?-catenin. BMC Cancer. 2013;13:48 pubmed publisher
  • immunocytochemistry; human; 1:500; fig 3
McClain C, Sim F, Goldman S. Pleiotrophin suppression of receptor protein tyrosine phosphatase-?/? maintains the self-renewal competence of fetal human oligodendrocyte progenitor cells. J Neurosci. 2012;32:15066-75 pubmed publisher
  • western blot; mouse; 1:1000
Wallmen B, Schrempp M, Hecht A. Intrinsic properties of Tcf1 and Tcf4 splice variants determine cell-type-specific Wnt/?-catenin target gene expression. Nucleic Acids Res. 2012;40:9455-69 pubmed publisher
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Baljinnyam B, Klauzinska M, Saffo S, Callahan R, Rubin J. Recombinant R-spondin2 and Wnt3a up- and down-regulate novel target genes in C57MG mouse mammary epithelial cells. PLoS ONE. 2012;7:e29455 pubmed publisher
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  • immunohistochemistry; mouse; 0.8 ug/ml; loading ...; fig 2i
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Gladden A, Hebert A, Schneeberger E, McClatchey A. The NF2 tumor suppressor, Merlin, regulates epidermal development through the establishment of a junctional polarity complex. Dev Cell. 2010;19:727-39 pubmed publisher
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Okura T, Ohkawara B, Takegami Y, Ito M, Masuda A, Seki T, et al. Mianserin suppresses R-spondin 2-induced activation of Wnt/β-catenin signaling in chondrocytes and prevents cartilage degradation in a rat model of osteoarthritis. Sci Rep. 2019;9:2808 pubmed publisher
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product information
Cat.# :
610154
Brand :
BD Transduction Laboratories
Name :
Catenin
Format :
Purified
Clone :
14/Beta-Catenin
Isotype :
Ms IgG 1
React :
Hu , Ms , Rat , Dog , Chick
Conc :
250 µg/ml
Apps :
IF , IHC , IP , WB
Size :
150 µg
Status :
RUO
more info or order :
company information