product summary
company name :
BD Biosciences
other brands :
Transduction Laboratories, PharMingen, Difco
product type :
antibody
product name :
FAK
catalog :
610088
quantity :
150 µg
price :
409.00 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
77/FAK
reactivity :
human, mouse, rat, dog, chicken
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation
more info or order :
citations: 23
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; human; fig 5c
  • western blot; human; fig 5f
Chen X, Wanggou S, Bodalia A, Zhu M, Dong W, Fan J, et al. A Feedforward Mechanism Mediated by Mechanosensitive Ion Channel PIEZO1 and Tissue Mechanics Promotes Glioma Aggression. Neuron. 2018;100:799-815.e7 pubmed publisher
  • western blot; dog; loading ...; fig 3b
Palesch D, Bosinger S, Tharp G, Vanderford T, Paiardini M, Chahroudi A, et al. Sooty mangabey genome sequence provides insight into AIDS resistance in a natural SIV host. Nature. 2018;553:77-81 pubmed publisher
  • western blot; mouse; 1:800; loading ...; fig s5a
Rashid M, Belmont J, Carpenter D, Turner C, Olson E. Neural-specific deletion of the focal adhesion adaptor protein paxillin slows migration speed and delays cortical layer formation. Development. 2017;144:4002-4014 pubmed publisher
  • western blot; human; 1:500; loading ...; fig 1b
Sato M, Kawana K, Adachi K, Fujimoto A, Yoshida M, Nakamura H, et al. Targeting glutamine metabolism and the focal adhesion kinase additively inhibits the mammalian target of the rapamycin pathway in spheroid cancer stem-like properties of ovarian clear cell carcinoma in vitro. Int J Oncol. 2017;50:1431-1438 pubmed publisher
  • western blot; human; loading ...; fig s2
Richter E, Harms M, Ventz K, Nölker R, Fraunholz M, Mostertz J, et al. Quantitative Proteomics Reveals the Dynamics of Protein Phosphorylation in Human Bronchial Epithelial Cells during Internalization, Phagosomal Escape, and Intracellular Replication of Staphylococcus aureus. J Proteome Res. 2016;15:4369-4386 pubmed
  • western blot; human; 1:500; fig 2b
Zeng F, Xie Y, Liao L, Li L, Chen B, Xie J, et al. Biological characterization of three immortalized esophageal epithelial cell lines. Mol Med Rep. 2016;14:4802-4810 pubmed publisher
  • western blot; human; fig 2
Segatto I, Massarut S, Boyle R, Baldassarre G, Walker D, Belletti B. Preclinical validation of a novel compound targeting p70S6 kinase in breast cancer. Aging (Albany NY). 2016;8:958-76 pubmed publisher
  • immunohistochemistry; mouse; 1:1000
Laklai H, Miroshnikova Y, Pickup M, Collisson E, Kim G, Barrett A, et al. Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression. Nat Med. 2016;22:497-505 pubmed publisher
  • western blot; human; loading ...; fig 2a
von Mässenhausen A, SANDERS C, Thewes B, Deng M, Queisser A, Vogel W, et al. MERTK as a novel therapeutic target in head and neck cancer. Oncotarget. 2016;7:32678-94 pubmed publisher
  • western blot; mouse; 1:2000; fig 5
Chen W, Cao Z, Sugaya S, Lopez M, Sendra V, Laver N, et al. Pathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated VEGFR-3. Nat Commun. 2016;7:11302 pubmed publisher
  • western blot; human; 1:1000; fig 5
Horton E, Humphries J, Stutchbury B, Jacquemet G, Ballestrem C, Barry S, et al. Modulation of FAK and Src adhesion signaling occurs independently of adhesion complex composition. J Cell Biol. 2016;212:349-64 pubmed publisher
  • western blot; human
Richter E, Harms M, Ventz K, Gierok P, Chilukoti R, Hildebrandt J, et al. A multi-omics approach identifies key hubs associated with cell type-specific responses of airway epithelial cells to staphylococcal alpha-toxin. PLoS ONE. 2015;10:e0122089 pubmed publisher
  • western blot; human; 1:500
Bassagañas S, Carvalho S, Dias A, Pérez Garay M, Ortiz M, Figueras J, et al. Pancreatic cancer cell glycosylation regulates cell adhesion and invasion through the modulation of ?2?1 integrin and E-cadherin function. PLoS ONE. 2014;9:e98595 pubmed publisher
  • immunocytochemistry; human
  • western blot; human
Flamini M, Gauna G, Sottile M, Nadin B, Sanchez A, Vargas Roig L. Retinoic acid reduces migration of human breast cancer cells: role of retinoic acid receptor beta. J Cell Mol Med. 2014;18:1113-23 pubmed publisher
Smyrek I, Mathew B, Fischer S, Lissek S, Becker S, Stelzer E. E-cadherin, actin, microtubules and FAK dominate different spheroid formation phases and important elements of tissue integrity. Biol Open. 2019;8: pubmed publisher
Takai K, Drain A, Lawson D, Littlepage L, Karpuj M, Kessenbrock K, et al. Discoidin domain receptor 1 (DDR1) ablation promotes tissue fibrosis and hypoxia to induce aggressive basal-like breast cancers. Genes Dev. 2018;32:244-257 pubmed publisher
Pryce B, Al Zahrani K, Dufresne S, Belkina N, Labrèche C, Patino Lopez G, et al. Deletion of the Ste20-like kinase SLK in skeletal muscle results in a progressive myopathy and muscle weakness. Skelet Muscle. 2017;7:3 pubmed publisher
Liu Y, Cui H, Huang X, Zhu B, Guan S, Cheng W, et al. MiR-7a is an important mediator in Fas-associated protein with death domain (FADD)-regulated expression of focal adhesion kinase (FAK). Oncotarget. 2016;7:51393-51407 pubmed publisher
Robertson J, Jacquemet G, Byron A, Jones M, Warwood S, Selley J, et al. Defining the phospho-adhesome through the phosphoproteomic analysis of integrin signalling. Nat Commun. 2015;6:6265 pubmed publisher
Teräväinen T, Myllymäki S, Friedrichs J, Strohmeyer N, Moyano J, Wu C, et al. ?V-integrins are required for mechanotransduction in MDCK epithelial cells. PLoS ONE. 2013;8:e71485 pubmed publisher
Bartolini B, Thelin M, Svensson L, Ghiselli G, van Kuppevelt T, Malmstrom A, et al. Iduronic acid in chondroitin/dermatan sulfate affects directional migration of aortic smooth muscle cells. PLoS ONE. 2013;8:e66704 pubmed publisher
Ambjørn M, Dubreuil V, Miozzo F, Nigon F, Møller B, Issazadeh Navikas S, et al. A loss-of-function screen for phosphatases that regulate neurite outgrowth identifies PTPN12 as a negative regulator of TrkB tyrosine phosphorylation. PLoS ONE. 2013;8:e65371 pubmed publisher
Jeanes A, Wang P, Moreno Layseca P, Paul N, Cheung J, Tsang R, et al. Specific ?-containing integrins exert differential control on proliferation and two-dimensional collective cell migration in mammary epithelial cells. J Biol Chem. 2012;287:24103-12 pubmed publisher
product information
Cat.# :
610088
Brand :
BD Transduction Laboratories
Name :
FAK
Format :
Purified
Clone :
77/FAK
Isotype :
Ms IgG 1
React :
Hu , Ms , Rat , Dog , Chick
Conc :
250 µg/ml
Apps :
Bioimg , IHC , IP , WB
Size :
150 µg
Status :
RUO
List Price :
409.00 USD
more info or order :
company information