product summary
company name :
BD Biosciences
other brands :
Transduction Laboratories, PharMingen, Difco
product type :
antibody
product name :
FAK
catalog :
610087
quantity :
50 µg
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
77/FAK
reactivity :
human, mouse, rat, dogs, chicken
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation
more info or order :
citations: 31
Published Application/Species/Sample/DilutionReference
  • western blot; human; 1:1000; loading ...; fig 3a
Shelton W, Thomas S, Alexander H, Thomes C, Conway D, Dubash A. Desmoglein-2 harnesses a PDZ-GEF2/Rap1 signaling axis to control cell spreading and focal adhesions independent of cell-cell adhesion. Sci Rep. 2021;11:13295 pubmed publisher
  • western blot; human; 1:1000; loading ...; fig 5c
Kariya Y, Oyama M, Suzuki T, Kariya Y. αvβ3 Integrin induces partial EMT independent of TGF-β signaling. Commun Biol. 2021;4:490 pubmed publisher
  • western blot; mouse; 1:1000; loading ...; fig 4b
Baghdadi M, Firmino J, Soni K, Evano B, Di Girolamo D, Mourikis P, et al. Notch-Induced miR-708 Antagonizes Satellite Cell Migration and Maintains Quiescence. Cell Stem Cell. 2018;23:859-868.e5 pubmed publisher
  • western blot; dogs; 1:1000; loading ...; fig 7b
Van Itallie C, Tietgens A, Aponte A, Gucek M, Cartagena Rivera A, Chadwick R, et al. MARCKS-related protein regulates cytoskeletal organization at cell-cell and cell-substrate contacts in epithelial cells. J Cell Sci. 2018;131: pubmed publisher
  • western blot; human; 1:1000; fig 3b
Wu Y, Jhao Y, Cheng Y, Chen Y. 15-Deoxy-?12,14-prostaglandin J2 inhibits migration of human thyroid carcinoma cells by disrupting focal adhesion complex and adherens junction. Oncol Lett. 2017;13:2569-2576 pubmed publisher
  • western blot; human; 1:1000
Jenny Zhou H, Qin L, Zhang H, Tang W, Ji W, He Y, et al. Endothelial exocytosis of angiopoietin-2 resulting from CCM3 deficiency contributes to cerebral cavernous malformation. Nat Med. 2016;22:1033-1042 pubmed publisher
  • western blot; mouse; 1:2000; fig 5
Chen W, Cao Z, Sugaya S, Lopez M, Sendra V, Laver N, et al. Pathological lymphangiogenesis is modulated by galectin-8-dependent crosstalk between podoplanin and integrin-associated VEGFR-3. Nat Commun. 2016;7:11302 pubmed publisher
  • western blot; human; loading ...; fig 4b
Atiq R, Hertz R, Eldad S, Smeir E, Bar Tana J. Suppression of B-Raf(V600E) cancers by MAPK hyper-activation. Oncotarget. 2016;7:18694-704 pubmed publisher
  • western blot; human; 1:500; fig s5
Kenific C, Stehbens S, Goldsmith J, Leidal A, Faure N, Ye J, et al. NBR1 enables autophagy-dependent focal adhesion turnover. J Cell Biol. 2016;212:577-90 pubmed publisher
  • immunohistochemistry; chicken; 1:200; fig s1
Long K, Moss L, Laursen L, Boulter L, ffrench Constant C. Integrin signalling regulates the expansion of neuroepithelial progenitors and neurogenesis via Wnt7a and Decorin. Nat Commun. 2016;7:10354 pubmed publisher
  • western blot; human; loading ...; fig 2a,2c
Min H, Yun H, Lee J, Lee H, Cho J, Jang H, et al. Targeting the insulin-like growth factor receptor and Src signaling network for the treatment of non-small cell lung cancer. Mol Cancer. 2015;14:113 pubmed publisher
  • western blot; human; 1:500
Kiss A, Gong X, Kowalewski J, Shafqat Abbasi H, Strömblad S, Lock J. Non-monotonic cellular responses to heterogeneity in talin protein expression-level. Integr Biol (Camb). 2015;7:1171-85 pubmed publisher
  • western blot; human; 1:100-1:300
Iguchi Y, Ishihara S, Uchida Y, Tajima K, Mizutani T, Kawabata K, et al. Filamin B Enhances the Invasiveness of Cancer Cells into 3D Collagen Matrices. Cell Struct Funct. 2015;40:61-7 pubmed publisher
  • western blot; human; fig 3, 4
Puig M, Lugo R, Gabasa M, Giménez A, Velásquez A, Galgoczy R, et al. Matrix stiffening and β1 integrin drive subtype-specific fibroblast accumulation in lung cancer. Mol Cancer Res. 2015;13:161-73 pubmed publisher
  • immunocytochemistry; human; 1:1000
  • western blot; human; 1:1000
Cheshenko N, Trepanier J, González P, Eugenin E, Jacobs W, Herold B. Herpes simplex virus type 2 glycoprotein H interacts with integrin ?v?3 to facilitate viral entry and calcium signaling in human genital tract epithelial cells. J Virol. 2014;88:10026-38 pubmed publisher
  • western blot; human; 1:500
Bassagañas S, Carvalho S, Dias A, Pérez Garay M, Ortiz M, Figueras J, et al. Pancreatic cancer cell glycosylation regulates cell adhesion and invasion through the modulation of ?2?1 integrin and E-cadherin function. PLoS ONE. 2014;9:e98595 pubmed publisher
  • western blot; human; fig 4
Zhu Z, Liu Y, Li K, Liu J, Wang H, Sun B, et al. Protein tyrosine phosphatase receptor U (PTPRU) is required for glioma growth and motility. Carcinogenesis. 2014;35:1901-10 pubmed publisher
Cao L, Wu Y, Wang X, Li X, Tan Z, Guan F. Role of Site-Specific Glycosylation in the I-Like Domain of Integrin β1 in Small Extracellular Vesicle-Mediated Malignant Behavior and FAK Activation. Int J Mol Sci. 2021;22: pubmed publisher
Jacquemet G, Stubb A, Saup R, Miihkinen M, Kremneva E, Hamidi H, et al. Filopodome Mapping Identifies p130Cas as a Mechanosensitive Regulator of Filopodia Stability. Curr Biol. 2019;29:202-216.e7 pubmed publisher
Grun D, Adhikary G, Eckert R. NRP-1 interacts with GIPC1 and α6/β4-integrins to increase YAP1/∆Np63α-dependent epidermal cancer stem cell survival. Oncogene. 2018;37:4711-4722 pubmed publisher
Miskolczi Z, Smith M, Rowling E, Ferguson J, Barriuso J, Wellbrock C. Collagen abundance controls melanoma phenotypes through lineage-specific microenvironment sensing. Oncogene. 2018;37:3166-3182 pubmed publisher
Kawano S, Torisu T, Esaki M, Torisu K, Matsuno Y, Kitazono T. Autophagy promotes degradation of internalized collagen and regulates distribution of focal adhesions to suppress cell adhesion. Biol Open. 2017;6:1644-1653 pubmed publisher
Day P, Thompson C, Lowy D, Schiller J. Interferon Gamma Prevents Infectious Entry of Human Papillomavirus 16 via an L2-Dependent Mechanism. J Virol. 2017;91: pubmed publisher
Moazzam M, Ye L, Sun P, Kynaston H, Jiang W. Knockdown of WAVE3 impairs HGF induced migration and invasion of prostate cancer cells. Cancer Cell Int. 2015;15:51 pubmed publisher
Konkel M, Samuelson D, Eucker T, Shelden E, O Loughlin J. Invasion of epithelial cells by Campylobacter jejuni is independent of caveolae. Cell Commun Signal. 2013;11:100 pubmed publisher
Kostourou V, Lechertier T, Reynolds L, Lees D, Baker M, Jones D, et al. FAK-heterozygous mice display enhanced tumour angiogenesis. Nat Commun. 2013;4:2020 pubmed publisher
Lahlou H, Sanguin Gendreau V, Frame M, Muller W. Focal adhesion kinase contributes to proliferative potential of ErbB2 mammary tumour cells but is dispensable for ErbB2 mammary tumour induction in vivo. Breast Cancer Res. 2012;14:R36 pubmed
Prosperi J, Khramtsov A, Khramtsova G, Goss K. Apc mutation enhances PyMT-induced mammary tumorigenesis. PLoS ONE. 2011;6:e29339 pubmed publisher
Bordeleau F, Galarneau L, Gilbert S, Loranger A, Marceau N. Keratin 8/18 modulation of protein kinase C-mediated integrin-dependent adhesion and migration of liver epithelial cells. Mol Biol Cell. 2010;21:1698-713 pubmed publisher
Kabuyama Y, Litman E, Templeton P, Metzner S, Witze E, Argast G, et al. A mediator of Rho-dependent invasion moonlights as a methionine salvage enzyme. Mol Cell Proteomics. 2009;8:2308-20 pubmed publisher
Watermann D, Gabriel B, Jager M, Orlowska Volk M, Hasenburg A, zur Hausen A, et al. Specific induction of pp125 focal adhesion kinase in human breast cancer. Br J Cancer. 2005;93:694-8 pubmed
product information
Cat.# :
610087
Brand :
BD Transduction Laboratories
Name :
FAK
Format :
Purified
Clone :
77/FAK
Isotype :
Ms IgG 1
React :
Hu , Ms , Rat , Dog , Chick
Conc :
250 µg/ml
Apps :
Bioimg , IHC , IP , WB
Size :
50 µg
Status :
RUO
more info or order :
company information