product summary
company name :
BD Biosciences
other brands :
Transduction Laboratories, PharMingen, Difco
product type :
antibody
product name :
Fibronectin
catalog :
610077
quantity :
50 µg
price :
212.00 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
10/Fibronectin
reactivity :
human, mouse, rat, dogs, chicken, bovine, swine
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section
more info or order :
citations: 59
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; rat; 1:50; loading ...; fig s1h
Zhang R, Wu Y, Xie F, Zhong Y, Wang Y, Xu M, et al. RGMa mediates reactive astrogliosis and glial scar formation through TGF?1/Smad2/3 signaling after stroke. Cell Death Differ. 2018;25:1503-1516 pubmed publisher
  • western blot; human; loading ...; fig 4b
Toloczko A, Guo F, Yuen H, Wen Q, Wood S, Ong Y, et al. Deubiquitinating Enzyme USP9X Suppresses Tumor Growth via LATS Kinase and Core Components of the Hippo Pathway. Cancer Res. 2017;77:4921-4933 pubmed publisher
  • immunocytochemistry; human; fig 1d
Xu W, Li B, Guan X, Chung S, Wang Y, Yip Y, et al. Cancer cell-secreted IGF2 instigates fibroblasts and bone marrow-derived vascular progenitor cells to promote cancer progression. Nat Commun. 2017;8:14399 pubmed publisher
  • immunohistochemistry; human; 1:2000; loading ...; fig s1b
  • western blot; human; 1:4000; loading ...; fig 1d
Gopal S, Veracini L, Grall D, Butori C, Schaub S, Audebert S, et al. Fibronectin-guided migration of carcinoma collectives. Nat Commun. 2017;8:14105 pubmed publisher
  • western blot; human; fig 1a
Che D, Zhou T, Lan Y, Xie J, Gong H, Li C, et al. High glucose-induced epithelial-mesenchymal transition contributes to the upregulation of fibrogenic factors in retinal pigment epithelial cells. Int J Mol Med. 2016;38:1815-1822 pubmed publisher
  • western blot; human; loading ...; fig 3c
Li H, Mai R, Huang H, Chou C, Chang Y, Chang Y, et al. DDX3 Represses Stemness by Epigenetically Modulating Tumor-suppressive miRNAs in Hepatocellular Carcinoma. Sci Rep. 2016;6:28637 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100; fig 2
Fessler E, Drost J, van Hooff S, Linnekamp J, Wang X, Jansen M, et al. TGFβ signaling directs serrated adenomas to the mesenchymal colorectal cancer subtype. EMBO Mol Med. 2016;8:745-60 pubmed publisher
  • western blot; human; fig 2
Lin S, Wang B, Lin C, Chien P, Wu Y, Ko J, et al. Chidamide alleviates TGF-?-induced epithelial-mesenchymal transition in lung cancer cell lines. Mol Biol Rep. 2016;43:687-95 pubmed publisher
  • immunocytochemistry; swine; fig 4
  • western blot; swine; 1:1000; fig 4
  • immunocytochemistry; human; fig 4
  • western blot; human; 1:1000; fig 4
Inada M, Izawa G, Kobayashi W, Ozawa M. 293 cells express both epithelial as well as mesenchymal cell adhesion molecules. Int J Mol Med. 2016;37:1521-7 pubmed publisher
  • immunohistochemistry; mouse; fig 2
Liu S, Wu C, Huang K, Wang C, Guan S, Chen L, et al. C/EBP homologous protein (CHOP) deficiency ameliorates renal fibrosis in unilateral ureteral obstructive kidney disease. Oncotarget. 2016;7:21900-12 pubmed publisher
  • western blot; human; fig 4
Zhang Y, Stefanovic B. Akt mediated phosphorylation of LARP6; critical step in biosynthesis of type I collagen. Sci Rep. 2016;6:22597 pubmed publisher
  • western blot; human; loading ...; fig 3g
Eichten A, Su J, Adler A, Zhang L, Ioffe E, Parveen A, et al. Resistance to Anti-VEGF Therapy Mediated by Autocrine IL6/STAT3 Signaling and Overcome by IL6 Blockade. Cancer Res. 2016;76:2327-39 pubmed publisher
  • western blot; human; 1:2000; fig 2f
Wang X, Jung Y, Jun S, Lee S, Wang W, Schneider A, et al. PAF-Wnt signaling-induced cell plasticity is required for maintenance of breast cancer cell stemness. Nat Commun. 2016;7:10633 pubmed publisher
  • western blot; human; 1:2000; fig 6
Gao Y, Zhao Y, Zhang J, Lu Y, Liu X, Geng P, et al. The dual function of PRMT1 in modulating epithelial-mesenchymal transition and cellular senescence in breast cancer cells through regulation of ZEB1. Sci Rep. 2016;6:19874 pubmed publisher
  • western blot; human; 1:1000; fig 2
Haraguchi M, Sato M, Ozawa M. CRISPR/Cas9n-Mediated Deletion of the Snail 1Gene (SNAI1) Reveals Its Role in Regulating Cell Morphology, Cell-Cell Interactions, and Gene Expression in Ovarian Cancer (RMG-1) Cells. PLoS ONE. 2015;10:e0132260 pubmed publisher
  • western blot; human; fig 2a
Fedorenko I, Abel E, Koomen J, Fang B, Wood E, Chen Y, et al. Fibronectin induction abrogates the BRAF inhibitor response of BRAF V600E/PTEN-null melanoma cells. Oncogene. 2016;35:1225-35 pubmed publisher
  • western blot; bovine
Izawa G, Kobayashi W, Haraguchi M, Sudo A, Ozawa M. The ectopic expression of Snail in MDBK cells does not induce epithelial-mesenchymal transition. Int J Mol Med. 2015;36:166-72 pubmed publisher
  • western blot; human; loading ...; fig 2c
He F, Li J, Xu J, Zhang S, Xu Y, Zhao W, et al. Decreased expression of ARID1A associates with poor prognosis and promotes metastases of hepatocellular carcinoma. J Exp Clin Cancer Res. 2015;34:47 pubmed publisher
  • western blot; human; 1:5000; loading ...; fig 4b
Sung B, Ketova T, Hoshino D, Zijlstra A, Weaver A. Directional cell movement through tissues is controlled by exosome secretion. Nat Commun. 2015;6:7164 pubmed publisher
  • immunocytochemistry; human; fig 2
Polioudaki H, Agelaki S, Chiotaki R, Politaki E, Mavroudis D, Matikas A, et al. Variable expression levels of keratin and vimentin reveal differential EMT status of circulating tumor cells and correlation with clinical characteristics and outcome of patients with metastatic breast cancer. BMC Cancer. 2015;15:399 pubmed publisher
  • western blot; human; loading ...; fig 1a
Qiao Y, Shiue C, Zhu J, Zhuang T, Jonsson P, Wright A, et al. AP-1-mediated chromatin looping regulates ZEB2 transcription: new insights into TNFα-induced epithelial-mesenchymal transition in triple-negative breast cancer. Oncotarget. 2015;6:7804-14 pubmed
  • western blot; human; fig 8
Stefanovic L, Longo L, Zhang Y, Stefanovic B. Characterization of binding of LARP6 to the 5' stem-loop of collagen mRNAs: implications for synthesis of type I collagen. RNA Biol. 2014;11:1386-401 pubmed publisher
  • immunocytochemistry; human; fig 2
Ghiabi P, Jiang J, Pasquier J, Maleki M, Abu Kaoud N, Halabi N, et al. Breast cancer cells promote a notch-dependent mesenchymal phenotype in endothelial cells participating to a pro-tumoral niche. J Transl Med. 2015;13:27 pubmed publisher
  • western blot; human; 1:1000; fig 5, 6
Zhou J, Lin J, Liu L, Zheng Y, Hong Z. Qianliening capsules influence the apoptosis of benign prostatic hyperplasia epithelial-1 cells by regulating the extracellular matrix. Mol Med Rep. 2015;11:3734-40 pubmed publisher
  • immunocytochemistry; human; 1:100; loading ...; fig 2a
  • western blot; human; 1:2500; loading ...; fig 2d
Joseph J, Conroy S, Pavlov K, Sontakke P, Tomar T, Eggens Meijer E, et al. Hypoxia enhances migration and invasion in glioblastoma by promoting a mesenchymal shift mediated by the HIF1α-ZEB1 axis. Cancer Lett. 2015;359:107-16 pubmed publisher
  • western blot; human; fig 4
Gong X, Yi J, Carmon K, Crumbley C, Xiong W, Thomas A, et al. Aberrant RSPO3-LGR4 signaling in Keap1-deficient lung adenocarcinomas promotes tumor aggressiveness. Oncogene. 2015;34:4692-701 pubmed publisher
  • western blot; mouse
Huang W, Akhter H, Jiang C, MacEwen M, Ding Q, Antony V, et al. Plasminogen activator inhibitor 1, fibroblast apoptosis resistance, and aging-related susceptibility to lung fibrosis. Exp Gerontol. 2015;61:62-75 pubmed publisher
  • immunocytochemistry; human; 1:50
  • western blot; human; 1:2500
Joseph J, Conroy S, Tomar T, Eggens Meijer E, Bhat K, Copray S, et al. TGF-β is an inducer of ZEB1-dependent mesenchymal transdifferentiation in glioblastoma that is associated with tumor invasion. Cell Death Dis. 2014;5:e1443 pubmed publisher
  • immunocytochemistry; human
von Roemeling C, Radisky D, Marlow L, Cooper S, Grebe S, ANASTASIADIS P, et al. Neuronal pentraxin 2 supports clear cell renal cell carcinoma by activating the AMPA-selective glutamate receptor-4. Cancer Res. 2014;74:4796-810 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100
Wagner D, Bonenfant N, Parsons C, Sokocevic D, Brooks E, Borg Z, et al. Comparative decellularization and recellularization of normal versus emphysematous human lungs. Biomaterials. 2014;35:3281-97 pubmed publisher
  • immunohistochemistry - paraffin section; swine; 1:100
  • immunohistochemistry - paraffin section; human; 1:100
Wagner D, Bonenfant N, Sokocevic D, Desarno M, Borg Z, Parsons C, et al. Three-dimensional scaffolds of acellular human and porcine lungs for high throughput studies of lung disease and regeneration. Biomaterials. 2014;35:2664-79 pubmed publisher
  • western blot; human
Wu C, Tang S, Wang P, Lee H, Ko J. Nickel-induced epithelial-mesenchymal transition by reactive oxygen species generation and E-cadherin promoter hypermethylation. J Biol Chem. 2012;287:25292-302 pubmed publisher
  • western blot; human
Kong Q, Hu L, Cao J, Huang Y, Xu L, Liang Y, et al. Epstein-Barr virus-encoded LMP2A induces an epithelial-mesenchymal transition and increases the number of side population stem-like cancer cells in nasopharyngeal carcinoma. PLoS Pathog. 2010;6:e1000940 pubmed publisher
Gomes A, Ilter D, Low V, Rosenzweig A, Shen Z, Schild T, et al. Dynamic Incorporation of Histone H3 Variants into Chromatin Is Essential for Acquisition of Aggressive Traits and Metastatic Colonization. Cancer Cell. 2019;36:402-417.e13 pubmed publisher
Heijink A, Everts M, Honeywell M, Richards R, Kok Y, de Vries E, et al. Modeling of Cisplatin-Induced Signaling Dynamics in Triple-Negative Breast Cancer Cells Reveals Mediators of Sensitivity. Cell Rep. 2019;28:2345-2357.e5 pubmed publisher
Sun Y, Yang Y, Keller K. Myosin-X Silencing in the Trabecular Meshwork Suggests a Role for Tunneling Nanotubes in Outflow Regulation. Invest Ophthalmol Vis Sci. 2019;60:843-851 pubmed publisher
Adhikary G, Grun D, Alexander H, Friedberg J, Xu W, Keillor J, et al. Transglutaminase is a mesothelioma cancer stem cell survival protein that is required for tumor formation. Oncotarget. 2018;9:34495-34505 pubmed publisher
Urano Y, Mori C, Fuji A, Konno K, Yamamoto T, Yashirogi S, et al. 6-Hydroxydopamine induces secretion of PARK7/DJ-1 via autophagy-based unconventional secretory pathway. Autophagy. 2018;14:1943-1958 pubmed publisher
Yang M, Yu X, Li X, Luo B, Yang W, Lin Y, et al. TNFAIP3 is required for FGFR1 activation-promoted proliferation and tumorigenesis of premalignant DCIS.COM human mammary epithelial cells. Breast Cancer Res. 2018;20:97 pubmed publisher
Zonneville J, Safina A, Truskinovsky A, Arteaga C, Bakin A. TGF-β signaling promotes tumor vasculature by enhancing the pericyte-endothelium association. BMC Cancer. 2018;18:670 pubmed publisher
Gulvady A, Dubois F, Deakin N, Goreczny G, Turner C. Hic-5 expression is a major indicator of cancer cell morphology, migration, and plasticity in three-dimensional matrices. Mol Biol Cell. 2018;29:1704-1717 pubmed publisher
Sun X, Fu X, Du M, Zhu M. Ex vivo gut culture for studying differentiation and migration of small intestinal epithelial cells. Open Biol. 2018;8: pubmed publisher
Kong X, Kuilman T, Shahrabi A, Boshuizen J, Kemper K, Song J, et al. Cancer drug addiction is relayed by an ERK2-dependent phenotype switch. Nature. 2017;550:270-274 pubmed publisher
Balasubramaniam S, Gopalakrishnapillai A, Petrelli N, Barwe S. Knockdown of sodium-calcium exchanger 1 induces epithelial-to-mesenchymal transition in kidney epithelial cells. J Biol Chem. 2017;292:11388-11399 pubmed publisher
Sung B, Weaver A. Exosome secretion promotes chemotaxis of cancer cells. Cell Adh Migr. 2017;11:187-195 pubmed publisher
Zhang Y, Stefanovic B. mTORC1 phosphorylates LARP6 to stimulate type I collagen expression. Sci Rep. 2017;7:41173 pubmed publisher
Norita R, Suzuki Y, Furutani Y, Takahashi K, Yoshimatsu Y, Podyma Inoue K, et al. Vasohibin-2 is required for epithelial-mesenchymal transition of ovarian cancer cells by modulating transforming growth factor-? signaling. Cancer Sci. 2017;108:419-426 pubmed publisher
Renner G, Noulet F, Mercier M, Choulier L, Etienne Selloum N, Gies J, et al. Expression/activation of ?5?1 integrin is linked to the ?-catenin signaling pathway to drive migration in glioma cells. Oncotarget. 2016;7:62194-62207 pubmed publisher
Werden S, Sphyris N, Sarkar T, Paranjape A, LaBaff A, Taube J, et al. Phosphorylation of serine 367 of FOXC2 by p38 regulates ZEB1 and breast cancer metastasis, without impacting primary tumor growth. Oncogene. 2016;35:5977-5988 pubmed publisher
Luo Y, Jiang Q, Wu J, Qiu J, Zhang W, Mei X, et al. Regulation of migration and invasion by Toll-like receptor-9 signaling network in prostate cancer. Oncotarget. 2015;6:22564-74 pubmed
Fisher M, Adhikary G, Xu W, Kerr C, Keillor J, Eckert R. Type II transglutaminase stimulates epidermal cancer stem cell epithelial-mesenchymal transition. Oncotarget. 2015;6:20525-39 pubmed
Yamada A, Aki T, Unuma K, Funakoshi T, Uemura K. Paraquat induces epithelial-mesenchymal transition-like cellular response resulting in fibrogenesis and the prevention of apoptosis in human pulmonary epithelial cells. PLoS ONE. 2015;10:e0120192 pubmed publisher
Ao M, Brewer B, Yang L, Franco Coronel O, Hayward S, Webb D, et al. Stretching fibroblasts remodels fibronectin and alters cancer cell migration. Sci Rep. 2015;5:8334 pubmed publisher
Yuki K, Yoshida Y, Inagaki R, Hiai H, Noda M. E-cadherin-downregulation and RECK-upregulation are coupled in the non-malignant epithelial cell line MCF10A but not in multiple carcinoma-derived cell lines. Sci Rep. 2014;4:4568 pubmed publisher
Krishnan M, Lapierre L, Knowles B, Goldenring J. Rab25 regulates integrin expression in polarized colonic epithelial cells. Mol Biol Cell. 2013;24:818-31 pubmed publisher
Kong X, Li G, Yuan Y, He Y, Wu X, Zhang W, et al. MicroRNA-7 inhibits epithelial-to-mesenchymal transition and metastasis of breast cancer cells via targeting FAK expression. PLoS ONE. 2012;7:e41523 pubmed publisher
Li R, Ackerman W, Mihai C, Volakis L, GHADIALI S, Kniss D. Myoferlin depletion in breast cancer cells promotes mesenchymal to epithelial shape change and stalls invasion. PLoS ONE. 2012;7:e39766 pubmed publisher
Zhao X, Malhotra G, Band H, Band V. Derivation of myoepithelial progenitor cells from bipotent mammary stem/progenitor cells. PLoS ONE. 2012;7:e35338 pubmed publisher
Kong C, Wang C, Wang L, Ma M, Niu C, Sun X, et al. NEDD9 is a positive regulator of epithelial-mesenchymal transition and promotes invasion in aggressive breast cancer. PLoS ONE. 2011;6:e22666 pubmed publisher
product information
Cat.# :
610077
Brand :
BD Transduction Laboratories
Name :
Fibronectin
Format :
Purified
Clone :
10/Fibronectin
Isotype :
Ms IgG 1
React :
Hu , Ms , Rat , Dog , Chick , Bov
Conc :
250 µg/ml
Apps :
IF , IHC , IP , WB
Size :
50 µg
Status :
RUO
List Price :
212.00 USD
more info or order :
company information