product summary
company name :
BD Biosciences
other brands :
Transduction Laboratories, PharMingen, Difco
product type :
antibody
product name :
CD45-BB515
catalog :
564590
clonality :
monoclonal
conjugate :
nonconjugated
clone name :
30-F11
reactivity :
human, mouse
application :
immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 127
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; 1:100; loading ...; fig 1a
Benkhoucha M, Tran N, Breville G, Senoner I, Bradfield P, Papayannopoulou T, et al. CD4+c-Met+Itgα4+ T cell subset promotes murine neuroinflammation. J Neuroinflammation. 2022;19:103 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:500; loading ...; fig 2b
Matsubara T, Iga T, Sugiura Y, Kusumoto D, Sanosaka T, Tai Nagara I, et al. Coupling of angiogenesis and odontogenesis orchestrates tooth mineralization in mice. J Exp Med. 2022;219: pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2i, 5g, 5i
Lin J, Chen Y, Zhu H, Cheng K, Wang H, Yu X, et al. Lymphatic Reconstruction in Kidney Allograft Aggravates Chronic Rejection by Promoting Alloantigen Presentation. Front Immunol. 2021;12:796260 pubmed publisher
  • flow cytometry; mouse; fig 3a
Zhu Y, Elsheikha H, Wang J, Fang S, He J, Zhu X, et al. Synergy between Toxoplasma gondii type I ΔGRA17 immunotherapy and PD-L1 checkpoint inhibition triggers the regression of targeted and distal tumors. J Immunother Cancer. 2021;9: pubmed publisher
  • flow cytometry; mouse; loading ...
Lee Y, Kim T, Kim Y, Kim S, Lee S, Seo S, et al. Microbiota-derived lactate promotes hematopoiesis and erythropoiesis by inducing stem cell factor production from leptin receptor+ niche cells. Exp Mol Med. 2021;53:1319-1331 pubmed publisher
  • flow cytometry; mouse; loading ...
Mathä L, Romera Hernandez M, Steer C, Yin Y, Orangi M, Shim H, et al. Migration of Lung Resident Group 2 Innate Lymphoid Cells Link Allergic Lung Inflammation and Liver Immunity. Front Immunol. 2021;12:679509 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:500; fig 6f
Schanz O, Cornez I, Yajnanarayana S, David F, Peer S, Gruber T, et al. Tumor rejection in Cblb -/- mice depends on IL-9 and Th9 cells. J Immunother Cancer. 2021;9: pubmed publisher
  • flow cytometry; mouse; 1:100; loading ...; fig s3b
Kemp S, Carpenter E, Steele N, Donahue K, Nwosu Z, Pacheco A, et al. Apolipoprotein E Promotes Immune Suppression in Pancreatic Cancer through NF-κB-Mediated Production of CXCL1. Cancer Res. 2021;81:4305-4318 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 5l
Kimura K, Ramirez K, Nguyen T, Yamashiro Y, Sada A, Yanagisawa H. Contribution of PDGFRα-positive cells in maintenance and injury responses in mouse large vessels. Sci Rep. 2021;11:8683 pubmed publisher
  • flow cytometry; human; 1:250; loading ...; fig s9
Qin W, Brands X, Van T Veer C, F de Vos A, Sirard J, J T H Roelofs J, et al. Bronchial epithelial DNA methyltransferase 3b dampens pulmonary immune responses during Pseudomonas aeruginosa infection. PLoS Pathog. 2021;17:e1009491 pubmed publisher
  • flow cytometry; mouse; fig s2
Okano J, Nakae Y, Nakagawa T, Katagi M, Terashima T, Nagakubo D, et al. A novel role for bone marrow-derived cells to recover damaged keratinocytes from radiation-induced injury. Sci Rep. 2021;11:5653 pubmed publisher
  • flow cytometry; mouse; fig 7
Mpekris F, Panagi M, Voutouri C, Martin J, Samuel R, Takahashi S, et al. Normalizing the Microenvironment Overcomes Vessel Compression and Resistance to Nano-immunotherapy in Breast Cancer Lung Metastasis. Adv Sci (Weinh). 2021;8:2001917 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 4a
Ni C, Gao S, Zheng Y, Liu P, Zhai Y, Huang W, et al. Annexin A1 Attenuates Neutrophil Migration and IL-6 Expression through Fpr2 in a Mouse Model of Streptococcus suis-Induced Meningitis. Infect Immun. 2021;89: pubmed publisher
  • flow cytometry; mouse; 1:100; loading ...; fig s6o
Yamamoto K, Venida A, Yano J, Biancur D, Kakiuchi M, Gupta S, et al. Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I. Nature. 2020;581:100-105 pubmed publisher
  • flow cytometry; mouse; 1:500; loading ...; fig 3d
Gang E, Kim H, Hsieh Y, Ruan Y, Ogana H, Lee S, et al. Integrin α6 mediates the drug resistance of acute lymphoblastic B-cell leukemia. Blood. 2020;136:210-223 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s4
Plemel J, Stratton J, Michaels N, Rawji K, Zhang E, Sinha S, et al. Microglia response following acute demyelination is heterogeneous and limits infiltrating macrophage dispersion. Sci Adv. 2020;6:eaay6324 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 4d
Reinhard K, Rengstl B, Oehm P, Michel K, Billmeier A, Hayduk N, et al. An RNA vaccine drives expansion and efficacy of claudin-CAR-T cells against solid tumors. Science. 2020;367:446-453 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1a, s4
Bell O, Copland D, Ward A, Nicholson L, Lange C, Chu C, et al. Single Eye mRNA-Seq Reveals Normalisation of the Retinal Microglial Transcriptome Following Acute Inflammation. Front Immunol. 2019;10:3033 pubmed publisher
  • flow cytometry; mouse; 1:200; fig s4h
Li A, Herbst R, Canner D, Schenkel J, Smith O, Kim J, et al. IL-33 Signaling Alters Regulatory T Cell Diversity in Support of Tumor Development. Cell Rep. 2019;29:2998-3008.e8 pubmed publisher
  • flow cytometry; mouse; 1:100; loading ...; fig s1a
de Morrée A, Klein J, Gan Q, Farup J, Urtasun A, Kanugovi A, et al. Alternative polyadenylation of Pax3 controls muscle stem cell fate and muscle function. Science. 2019;366:734-738 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig s3d
Aykut B, Pushalkar S, Chen R, Li Q, Abengozar R, Kim J, et al. The fungal mycobiome promotes pancreatic oncogenesis via activation of MBL. Nature. 2019;574:264-267 pubmed publisher
  • immunocytochemistry; mouse; fig 5
Ramani V, Lemaire C, Triboulet M, Casey K, Heirich K, Renier C, et al. Investigating circulating tumor cells and distant metastases in patient-derived orthotopic xenograft models of triple-negative breast cancer. Breast Cancer Res. 2019;21:98 pubmed publisher
  • flow cytometry; mouse; 1:50; loading ...; fig s2f
Guiu J, Hannezo E, Yui S, Demharter S, Ulyanchenko S, Maimets M, et al. Tracing the origin of adult intestinal stem cells. Nature. 2019;570:107-111 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:500; loading ...; fig s1d
Kuriakose J, Redecke V, Guy C, Zhou J, Wu R, Ippagunta S, et al. Patrolling monocytes promote the pathogenesis of early lupus-like glomerulonephritis. J Clin Invest. 2019;129:2251-2265 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 2b
  • flow cytometry; mouse; 1:200; loading ...; fig 5s1c
Walens A, DiMarco A, Lupo R, Kroger B, Damrauer J, Alvarez J. CCL5 promotes breast cancer recurrence through macrophage recruitment in residual tumors. elife. 2019;8: pubmed publisher
  • flow cytometry; mouse; 1:800; loading ...
Lee J, Stone M, Porrett P, Thomas S, Komar C, Li J, et al. Hepatocytes direct the formation of a pro-metastatic niche in the liver. Nature. 2019;567:249-252 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3a
  • immunocytochemistry; mouse; loading ...; fig s5a
Liu M, O Connor R, Trefely S, Graham K, Snyder N, Beatty G. Metabolic rewiring of macrophages by CpG potentiates clearance of cancer cells and overcomes tumor-expressed CD47-mediated 'don't-eat-me' signal. Nat Immunol. 2019;20:265-275 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1a
Mikolajczyk T, Nosalski R, Skiba D, Koziol J, Mazur M, Justo Junior A, et al. 1,2,3,4,6-Penta-O-galloyl-β-d-glucose modulates perivascular inflammation and prevents vascular dysfunction in angiotensin II-induced hypertension. Br J Pharmacol. 2019;176:1951-1965 pubmed publisher
  • flow cytometry; mouse; 1:400; loading ...
Jones G, Bain C, Fenton T, Kelly A, Brown S, Ivens A, et al. Dynamics of Colon Monocyte and Macrophage Activation During Colitis. Front Immunol. 2018;9:2764 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s5
Dong S, Harrington B, Hu E, Greene J, Lehman A, Tran M, et al. PI3K p110δ inactivation antagonizes chronic lymphocytic leukemia and reverses T cell immune suppression. J Clin Invest. 2019;129:122-136 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s2
Adam L, Lopez Gonzalez M, Björk A, Pålsson S, Poux C, Wahren Herlenius M, et al. Early Resistance of Non-virulent Mycobacterial Infection in C57BL/6 Mice Is Associated With Rapid Up-Regulation of Antimicrobial Cathelicidin Camp. Front Immunol. 2018;9:1939 pubmed publisher
Rawji K, Young A, Ghosh T, Michaels N, Mirzaei R, Kappen J, et al. Niacin-mediated rejuvenation of macrophage/microglia enhances remyelination of the aging central nervous system. Acta Neuropathol. 2020;139:893-909 pubmed publisher
Zheng W, Zhang H, Zhao D, Zhang J, Pollard J. Lung Mammary Metastases but Not Primary Tumors Induce Accumulation of Atypical Large Platelets and Their Chemokine Expression. Cell Rep. 2019;29:1747-1755.e4 pubmed publisher
Diaz Osterman C, Ozmadenci D, Kleinschmidt E, Taylor K, Barrie A, Jiang S, et al. FAK activity sustains intrinsic and acquired ovarian cancer resistance to platinum chemotherapy. elife. 2019;8: pubmed publisher
Gross K, Zhou W, Breindel J, Ouyang J, Jin D, Sokol E, et al. Loss of Slug Compromises DNA Damage Repair and Accelerates Stem Cell Aging in Mammary Epithelium. Cell Rep. 2019;28:394-407.e6 pubmed publisher
Ponzetta A, Carriero R, Carnevale S, Barbagallo M, Molgora M, Perucchini C, et al. Neutrophils Driving Unconventional T Cells Mediate Resistance against Murine Sarcomas and Selected Human Tumors. Cell. 2019;178:346-360.e24 pubmed publisher
Yankaskas C, Thompson K, Paul C, Vitolo M, Mistriotis P, Mahendra A, et al. A microfluidic assay for the quantification of the metastatic propensity of breast cancer specimens. Nat Biomed Eng. 2019;3:452-465 pubmed publisher
Kellish P, Shabashvili D, Rahman M, Nawab A, Guijarro M, Zhang M, et al. Oncolytic virotherapy for small-cell lung cancer induces immune infiltration and prolongs survival. J Clin Invest. 2019;129:2279-2292 pubmed publisher
Sala D, Cunningham T, Stec M, Etxaniz U, Nicoletti C, Dall Agnese A, et al. The Stat3-Fam3a axis promotes muscle stem cell myogenic lineage progression by inducing mitochondrial respiration. Nat Commun. 2019;10:1796 pubmed publisher
Wu J, Chen Y, Dobbs N, Sakai T, Liou J, Miner J, et al. STING-mediated disruption of calcium homeostasis chronically activates ER stress and primes T cell death. J Exp Med. 2019;: pubmed publisher
Silva H, Bafica A, Rodrigues Luiz G, Chi J, Santos P, Reis B, et al. Vasculature-associated fat macrophages readily adapt to inflammatory and metabolic challenges. J Exp Med. 2019;216:786-806 pubmed publisher
Fausther Bovendo H, Qiu X, He S, Bello A, Audet J, Ippolito G, et al. NK Cells Accumulate in Infected Tissues and Contribute to Pathogenicity of Ebola Virus in Mice. J Virol. 2019;93: pubmed publisher
Pijuan Sala B, Griffiths J, Guibentif C, Hiscock T, Jawaid W, Calero Nieto F, et al. A single-cell molecular map of mouse gastrulation and early organogenesis. Nature. 2019;566:490-495 pubmed publisher
Cui S, Li L, Yu R, Downes M, Evans R, Hulin J, et al. β-Catenin is essential for differentiation of primary myoblasts via cooperation with MyoD and α-catenin. Development. 2019;146: pubmed publisher
Camilio K, Wang M, Mauseth B, Waagene S, Kvalheim G, Rekdal Ø, et al. Combining the oncolytic peptide LTX-315 with doxorubicin demonstrates therapeutic potential in a triple-negative breast cancer model. Breast Cancer Res. 2019;21:9 pubmed publisher
Ferrari N, Ranftl R, Chicherova I, Slaven N, Moeendarbary E, Farrugia A, et al. Dickkopf-3 links HSF1 and YAP/TAZ signalling to control aggressive behaviours in cancer-associated fibroblasts. Nat Commun. 2019;10:130 pubmed publisher
Tornillo G, Knowlson C, Kendrick H, Cooke J, Mirza H, Aurrekoetxea Rodríguez I, et al. Dual Mechanisms of LYN Kinase Dysregulation Drive Aggressive Behavior in Breast Cancer Cells. Cell Rep. 2018;25:3674-3692.e10 pubmed publisher
Otxoa de Amezaga A, Miro Mur F, Pedragosa J, Gallizioli M, Justicia C, Gaja Capdevila N, et al. Microglial cell loss after ischemic stroke favors brain neutrophil accumulation. Acta Neuropathol. 2019;137:321-341 pubmed publisher
Wei Y, Chhiba K, Zhang F, Ye X, Wang L, Zhang L, et al. Mast Cell-Specific Expression of Human Siglec-8 in Conditional Knock-in Mice. Int J Mol Sci. 2018;20: pubmed publisher
Lee Y, Kim T, Kim Y, Lee S, Kim S, Kang S, et al. Microbiota-Derived Lactate Accelerates Intestinal Stem-Cell-Mediated Epithelial Development. Cell Host Microbe. 2018;24:833-846.e6 pubmed publisher
Du X, de Almeida P, Manieri N, de Almeida Nagata D, Wu T, Harden Bowles K, et al. CD226 regulates natural killer cell antitumor responses via phosphorylation-mediated inactivation of transcription factor FOXO1. Proc Natl Acad Sci U S A. 2018;115:E11731-E11740 pubmed publisher
Zhang W, Li Q, Li D, Li J, Aki D, Liu Y. The E3 ligase VHL controls alveolar macrophage function via metabolic-epigenetic regulation. J Exp Med. 2018;215:3180-3193 pubmed publisher
Safronova A, Araujo A, Camanzo E, Moon T, Elliott M, Beiting D, et al. Alarmin S100A11 initiates a chemokine response to the human pathogen Toxoplasma gondii. Nat Immunol. 2019;20:64-72 pubmed publisher
Walsh S, Bastin D, Chen L, Nguyen A, Storbeck C, Lefebvre C, et al. Type I IFN blockade uncouples immunotherapy-induced antitumor immunity and autoimmune toxicity. J Clin Invest. 2019;129:518-530 pubmed publisher
Gentek R, Ghigo C, Hoeffel G, Jorquera A, Msallam R, Wienert S, et al. Epidermal γδ T cells originate from yolk sac hematopoiesis and clonally self-renew in the adult. J Exp Med. 2018;215:2994-3005 pubmed publisher
Lane R, Femel J, Breazeale A, Loo C, Thibault G, Kaempf A, et al. IFNγ-activated dermal lymphatic vessels inhibit cytotoxic T cells in melanoma and inflamed skin. J Exp Med. 2018;215:3057-3074 pubmed publisher
Atkinson J, Hwang M, Reyes Rodriguez A, Bergmann C. Dynamics of Virus-Specific Memory B Cells and Plasmablasts following Viral Infection of the Central Nervous System. J Virol. 2019;93: pubmed publisher
Postat J, Olekhnovitch R, Lemaitre F, Bousso P. A Metabolism-Based Quorum Sensing Mechanism Contributes to Termination of Inflammatory Responses. Immunity. 2018;49:654-665.e5 pubmed publisher
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Plantamura E, Dzutsev A, Chamaillard M, Djebali S, Moudombi L, Boucinha L, et al. MAVS deficiency induces gut dysbiotic microbiota conferring a proallergic phenotype. Proc Natl Acad Sci U S A. 2018;115:10404-10409 pubmed publisher
Luo H, Winkelmann E, Zhu S, Ru W, Mays E, Silvas J, et al. Peli1 facilitates virus replication and promotes neuroinflammation during West Nile virus infection. J Clin Invest. 2018;128:4980-4991 pubmed publisher
Lin C, Titchenell P, Keil J, Garcia Ocana A, Bolinger M, ABCOUWER S, et al. Inhibition of Atypical Protein Kinase C Reduces Inflammation-Induced Retinal Vascular Permeability. Am J Pathol. 2018;188:2392-2405 pubmed publisher
Loyher P, Hamon P, Laviron M, Meghraoui Kheddar A, Goncalves E, Deng Z, et al. Macrophages of distinct origins contribute to tumor development in the lung. J Exp Med. 2018;215:2536-2553 pubmed publisher
Rosato R, Dávila González D, Choi D, Qian W, Chen W, Kozielski A, et al. Evaluation of anti-PD-1-based therapy against triple-negative breast cancer patient-derived xenograft tumors engrafted in humanized mouse models. Breast Cancer Res. 2018;20:108 pubmed publisher
Schniering J, Guo L, Brunner M, Schibli R, Ye S, Distler O, et al. Evaluation of 99mTc-rhAnnexin V-128 SPECT/CT as a diagnostic tool for early stages of interstitial lung disease associated with systemic sclerosis. Arthritis Res Ther. 2018;20:183 pubmed publisher
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Pires S, Parker D. IL-1β activation in response to Staphylococcus aureus lung infection requires inflammasome-dependent and independent mechanisms. Eur J Immunol. 2018;48:1707-1716 pubmed publisher
Kiang L, Ross B, Yao J, Shanmugam S, Andrews C, Hansen S, et al. Vitreous Cytokine Expression and a Murine Model Suggest a Key Role of Microglia in the Inflammatory Response to Retinal Detachment. Invest Ophthalmol Vis Sci. 2018;59:3767-3778 pubmed publisher
Dá Mesquita S, Louveau A, Vaccari A, Smirnov I, Cornelison R, Kingsmore K, et al. Functional aspects of meningeal lymphatics in ageing and Alzheimer's disease. Nature. 2018;560:185-191 pubmed publisher
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Diao J, Gu H, Tang M, Zhao J, Cattral M. Tumor Dendritic Cells (DCs) Derived from Precursors of Conventional DCs Are Dispensable for Intratumor CTL Responses. J Immunol. 2018;201:1306-1314 pubmed publisher
Kiffin R, Grauers Wiktorin H, Nilsson M, Aurelius J, Aydin E, Lenox B, et al. Anti-Leukemic Properties of Histamine in Monocytic Leukemia: The Role of NOX2. Front Oncol. 2018;8:218 pubmed publisher
Okunuki Y, Mukai R, Pearsall E, Klokman G, Husain D, Park D, et al. Microglia inhibit photoreceptor cell death and regulate immune cell infiltration in response to retinal detachment. Proc Natl Acad Sci U S A. 2018;115:E6264-E6273 pubmed publisher
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Jeon S, Rowe A, Carroll K, Harvey S, Hendricks R. PD-L1/B7-H1 Inhibits Viral Clearance by Macrophages in HSV-1-Infected Corneas. J Immunol. 2018;200:3711-3719 pubmed publisher
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Peranzoni E, Lemoine J, Vimeux L, Feuillet V, Barrin S, Kantari Mimoun C, et al. Macrophages impede CD8 T cells from reaching tumor cells and limit the efficacy of anti-PD-1 treatment. Proc Natl Acad Sci U S A. 2018;115:E4041-E4050 pubmed publisher
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Spirig R, Campbell I, Koernig S, Chen C, Lewis B, BUTCHER R, et al. rIgG1 Fc Hexamer Inhibits Antibody-Mediated Autoimmune Disease via Effects on Complement and FcγRs. J Immunol. 2018;200:2542-2553 pubmed publisher
Vaartjes D, Nandakumar K, Holmdahl R, Raposo B. Increased salt exposure affects both lymphoid and myeloid effector functions, influencing innate-associated disease but not T-cell-associated autoimmunity. Immunology. 2018;: pubmed publisher
Hwang M, Bergmann C. Alpha/Beta Interferon (IFN-?/?) Signaling in Astrocytes Mediates Protection against Viral Encephalomyelitis and Regulates IFN-?-Dependent Responses. J Virol. 2018;92: pubmed publisher
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Djurec M, Grana O, Lee A, Troulé K, Espinet E, Cabras L, et al. Saa3 is a key mediator of the protumorigenic properties of cancer-associated fibroblasts in pancreatic tumors. Proc Natl Acad Sci U S A. 2018;115:E1147-E1156 pubmed publisher
Chockley P, Chen J, Chen G, Beer D, Standiford T, Keshamouni V. Epithelial-mesenchymal transition leads to NK cell-mediated metastasis-specific immunosurveillance in lung cancer. J Clin Invest. 2018;128:1384-1396 pubmed publisher
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Caballero S, Kent D, Sengupta N, Li Calzi S, Shaw L, Beli E, et al. Bone Marrow-Derived Cell Recruitment to the Neurosensory Retina and Retinal Pigment Epithelial Cell Layer Following Subthreshold Retinal Phototherapy. Invest Ophthalmol Vis Sci. 2017;58:5164-5176 pubmed publisher
Brown S, Smith C, Meuth A, Khan M, Aroor A, Cleeton H, et al. Dipeptidyl Peptidase-4 Inhibition With Saxagliptin Ameliorates Angiotensin II-Induced Cardiac Diastolic Dysfunction in Male Mice. Endocrinology. 2017;158:3592-3604 pubmed publisher
De Feo D, Merlini A, Brambilla E, Ottoboni L, Laterza C, Menon R, et al. Neural precursor cell-secreted TGF-β2 redirects inflammatory monocyte-derived cells in CNS autoimmunity. J Clin Invest. 2017;127:3937-3953 pubmed publisher
Atkinson J, Bergmann C. Protective Humoral Immunity in the Central Nervous System Requires Peripheral CD19-Dependent Germinal Center Formation following Coronavirus Encephalomyelitis. J Virol. 2017;91: pubmed publisher
Xiao S, Shterev I, Zhang W, Young L, Shieh J, Moore M, et al. Sublethal Total Body Irradiation Causes Long-Term Deficits in Thymus Function by Reducing Lymphoid Progenitors. J Immunol. 2017;199:2701-2712 pubmed publisher
Martin T, Möglich A, Felix I, Förtsch C, Rittlinger A, Palmer A, et al. Rho-inhibiting C2IN-C3 fusion toxin inhibits chemotactic recruitment of human monocytes ex vivo and in mice in vivo. Arch Toxicol. 2018;92:323-336 pubmed publisher
Jung K, Heishi T, Incio J, Huang Y, Beech E, Pinter M, et al. Targeting CXCR4-dependent immunosuppressive Ly6Clow monocytes improves antiangiogenic therapy in colorectal cancer. Proc Natl Acad Sci U S A. 2017;114:10455-10460 pubmed publisher
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