product summary
company name :
BD Biosciences
other brands :
Transduction Laboratories, PharMingen, Difco
product type :
antibody
product name :
I-A/I-E
catalog :
556999
quantity :
0.5 mg
price :
245.00 USD
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
M5/114.15.2
reactivity :
mouse
application :
western blot, immunohistochemistry, flow cytometry, immunohistochemistry - frozen section, immunohistochemistry - free floating section
more info or order :
citations: 67
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry; mouse; 1:100; loading ...; fig 5e
Ma W, Silverman S, Zhao L, Villasmil R, Campos M, Amaral J, et al. Absence of TGFβ signaling in retinal microglia induces retinal degeneration and exacerbates choroidal neovascularization. elife. 2019;8: pubmed publisher
  • flow cytometry; mouse; 1:100; loading ...; fig 2a
Vega Angeles V, Terrazas L, Ledesma Soto Y, Jimenez L, Landa A. Taenia solium glutathione transferase fraction activates macrophages and favors the development of Th1-type response. Biosci Rep. 2019;39: pubmed publisher
  • flow cytometry; mouse; loading ...; fig 6a
Alam M, Yang D, Trivett A, Meyer T, Oppenheim J. HMGN1 and R848 Synergistically Activate Dendritic Cells Using Multiple Signaling Pathways. Front Immunol. 2018;9:2982 pubmed publisher
  • flow cytometry; mouse; 1:800; loading ...; fig 2a
Jones G, Bain C, Fenton T, Kelly A, Brown S, Ivens A, et al. Dynamics of Colon Monocyte and Macrophage Activation During Colitis. Front Immunol. 2018;9:2764 pubmed publisher
  • flow cytometry; mouse; 1:200; loading ...; fig s5c
Huynh J, Lin C, Kimmey J, Jarjour N, Schwarzkopf E, Bradstreet T, et al. Bhlhe40 is an essential repressor of IL-10 during Mycobacterium tuberculosis infection. J Exp Med. 2018;215:1823-1838 pubmed publisher
  • flow cytometry; mouse; 1:400; loading ...; fig 1c
Tsubaki T, Kadonosono T, Sakurai S, Shiozawa T, Goto T, Sakai S, et al. Novel adherent CD11b+ Gr-1+ tumor-infiltrating cells initiate an immunosuppressive tumor microenvironment. Oncotarget. 2018;9:11209-11226 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s1b
Ebner F, Sedlyarov V, Tasciyan S, Ivin M, Kratochvill F, Gratz N, et al. The RNA-binding protein tristetraprolin schedules apoptosis of pathogen-engaged neutrophils during bacterial infection. J Clin Invest. 2017;127:2051-2065 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2a
Briseño C, Gargaro M, Durai V, Davidson J, Theisen D, Anderson D, et al. Deficiency of transcription factor RelB perturbs myeloid and DC development by hematopoietic-extrinsic mechanisms. Proc Natl Acad Sci U S A. 2017;114:3957-3962 pubmed publisher
  • flow cytometry; mouse; fig 5c
Oh J, Oh D, Jung H, Lee H. A mechanism for the induction of type 2 immune responses by a protease allergen in the genital tract. Proc Natl Acad Sci U S A. 2017;114:E1188-E1195 pubmed publisher
  • flow cytometry; mouse; loading ...
Yanagisawa H, Hashimoto M, Minagawa S, Takasaka N, Ma R, Moermans C, et al. Role of IL-17A in murine models of COPD airway disease. Am J Physiol Lung Cell Mol Physiol. 2017;312:L122-L130 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 5d
Ellman D, Degn M, Lund M, Clausen B, Novrup H, Flæng S, et al. Genetic Ablation of Soluble TNF Does Not Affect Lesion Size and Functional Recovery after Moderate Spinal Cord Injury in Mice. Mediators Inflamm. 2016;2016:2684098 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s2
Lund M, Greer J, Dixit A, Alvarado R, McCauley Winter P, To J, et al. A parasite-derived 68-mer peptide ameliorates autoimmune disease in murine models of Type 1 diabetes and multiple sclerosis. Sci Rep. 2016;6:37789 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1a
Calmette J, Bertrand M, Vétillard M, Ellouze M, Flint S, Nicolas V, et al. Glucocorticoid-Induced Leucine Zipper Protein Controls Macropinocytosis in Dendritic Cells. J Immunol. 2016;197:4247-4256 pubmed
  • flow cytometry; mouse; loading ...; fig 2C
Alves da Costa T, Di Gangi R, Thomé R, Barreto Felisbino M, Pires Bonfanti A, Lumi Watanabe Ishikawa L, et al. Severe Changes in Thymic Microenvironment in a Chronic Experimental Model of Paracoccidioidomycosis. PLoS ONE. 2016;11:e0164745 pubmed publisher
  • flow cytometry; mouse; fig 1a
Chow K, Delconte R, Huntington N, Tarlinton D, Sutherland R, Zhan Y, et al. Innate Allorecognition Results in Rapid Accumulation of Monocyte-Derived Dendritic Cells. J Immunol. 2016;197:2000-8 pubmed publisher
  • flow cytometry; mouse; fig 4B
Veinotte L, Gebremeskel S, Johnston B. CXCL16-positive dendritic cells enhance invariant natural killer T cell-dependent IFN? production and tumor control. Oncoimmunology. 2016;5:e1160979 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2b
Lo T, Silveira P, Fromm P, Verma N, Vu P, Kupresanin F, et al. Characterization of the Expression and Function of the C-Type Lectin Receptor CD302 in Mice and Humans Reveals a Role in Dendritic Cell Migration. J Immunol. 2016;197:885-98 pubmed publisher
  • flow cytometry; mouse
Lee S, Hong S, Verma V, Lee Y, Duong T, Jeong K, et al. Flagellin is a strong vaginal adjuvant of a therapeutic vaccine for genital cancer. Oncoimmunology. 2016;5:e1081328 pubmed
  • immunohistochemistry - frozen section; mouse; 1:7500; fig s1
Sipe G, Lowery R, Tremblay M, Kelly E, Lamantia C, Majewska A. Microglial P2Y12 is necessary for synaptic plasticity in mouse visual cortex. Nat Commun. 2016;7:10905 pubmed publisher
  • flow cytometry; mouse; fig 1
Onodera T, Fukuhara A, Jang M, Shin J, Aoi K, Kikuta J, et al. Adipose tissue macrophages induce PPARγ-high FOXP3(+) regulatory T cells. Sci Rep. 2015;5:16801 pubmed publisher
  • western blot; mouse; 1:200; fig 5
Asai H, Ikezu S, Tsunoda S, Medalla M, Luebke J, Haydar T, et al. Depletion of microglia and inhibition of exosome synthesis halt tau propagation. Nat Neurosci. 2015;18:1584-93 pubmed publisher
  • flow cytometry; mouse; fig 1
Buerger S, Herrmann V, Mundt S, Trautwein N, Groettrup M, Basler M. The Ubiquitin-like Modifier FAT10 Is Selectively Expressed in Medullary Thymic Epithelial Cells and Modifies T Cell Selection. J Immunol. 2015;195:4106-16 pubmed publisher
  • flow cytometry; mouse
Dal Secco D, Wang J, Zeng Z, Kolaczkowska E, Wong C, Petri B, et al. A dynamic spectrum of monocytes arising from the in situ reprogramming of CCR2+ monocytes at a site of sterile injury. J Exp Med. 2015;212:447-56 pubmed publisher
  • immunohistochemistry - free floating section; mouse; 1:5000; fig 8
Kelly E, Opanashuk L, Majewska A. The effects of postnatal exposure to low-dose bisphenol-A on activity-dependent plasticity in the mouse sensory cortex. Front Neuroanat. 2014;8:117 pubmed publisher
  • flow cytometry; mouse
Meraz I, Hearnden C, Liu X, Yang M, Williams L, Savage D, et al. Multivalent presentation of MPL by porous silicon microparticles favors T helper 1 polarization enhancing the anti-tumor efficacy of doxorubicin nanoliposomes. PLoS ONE. 2014;9:e94703 pubmed publisher
  • flow cytometry; mouse
Hirayama T, Asano Y, Iida H, Watanabe T, Nakamura T, Goitsuka R. Meis1 is required for the maintenance of postnatal thymic epithelial cells. PLoS ONE. 2014;9:e89885 pubmed publisher
  • flow cytometry; mouse
Osada M, Singh V, Wu K, Sant Angelo D, Pezzano M. Label retention identifies a multipotent mesenchymal stem cell-like population in the postnatal thymus. PLoS ONE. 2013;8:e83024 pubmed publisher
  • flow cytometry; mouse; fig 4
Kim J, Zarjou A, Traylor A, Bolisetty S, Jaimes E, Hull T, et al. In vivo regulation of the heme oxygenase-1 gene in humanized transgenic mice. Kidney Int. 2012;82:278-91 pubmed publisher
Ponzetta A, Carriero R, Carnevale S, Barbagallo M, Molgora M, Perucchini C, et al. Neutrophils Driving Unconventional T Cells Mediate Resistance against Murine Sarcomas and Selected Human Tumors. Cell. 2019;178:346-360.e24 pubmed publisher
Denton A, Innocentin S, Carr E, Bradford B, Lafouresse F, Mabbott N, et al. Type I interferon induces CXCL13 to support ectopic germinal center formation. J Exp Med. 2019;216:621-637 pubmed publisher
Lauron E, Yang L, Harvey I, Sojka D, Williams G, Paley M, et al. Viral MHCI inhibition evades tissue-resident memory T cell formation and responses. J Exp Med. 2019;216:117-132 pubmed publisher
Ravindranathan S, Nguyen K, Kurtz S, Frazier H, Smith S, Koppolu B, et al. Tumor-derived granulocyte colony-stimulating factor diminishes efficacy of breast tumor cell vaccines. Breast Cancer Res. 2018;20:126 pubmed publisher
Pires S, Parker D. IL-1β activation in response to Staphylococcus aureus lung infection requires inflammasome-dependent and independent mechanisms. Eur J Immunol. 2018;48:1707-1716 pubmed publisher
Thyagarajan H, Lancaster J, Lira S, Ehrlich L. CCR8 is expressed by post-positive selection CD4-lineage thymocytes but is dispensable for central tolerance induction. PLoS ONE. 2018;13:e0200765 pubmed publisher
Batugedara H, Li J, Chen G, Lu D, Patel J, Jang J, et al. Hematopoietic cell-derived RELMα regulates hookworm immunity through effects on macrophages. J Leukoc Biol. 2018;104:855-869 pubmed publisher
Wu X, Gowda N, Kawasawa Y, Gowda D. A malaria protein factor induces IL-4 production by dendritic cells via PI3K-Akt-NF-κB signaling independent of MyD88/TRIF and promotes Th2 response. J Biol Chem. 2018;293:10425-10434 pubmed publisher
Khong H, Volmari A, Sharma M, Dai Z, Imo C, Hailemichael Y, et al. Peptide Vaccine Formulation Controls the Duration of Antigen Presentation and Magnitude of Tumor-Specific CD8+ T Cell Response. J Immunol. 2018;200:3464-3474 pubmed publisher
Gopinath S, Kim M, Rakib T, Wong P, Van Zandt M, Barry N, et al. Topical application of aminoglycoside antibiotics enhances host resistance to viral infections in a microbiota-independent manner. Nat Microbiol. 2018;3:611-621 pubmed publisher
Kauffmann F, Meert E, de Jonge K, Elkrim Y, Hanot Mambres D, Denis O, et al. STAT6 Mediates Footpad Immunopathology in the Absence of IL-12p40 Following Infection of Susceptible BALB/c Mice With Leishmania major. Front Immunol. 2018;9:503 pubmed publisher
Durai V, Bagadia P, Briseño C, Theisen D, Iwata A, Davidson J, et al. Altered compensatory cytokine signaling underlies the discrepancy between Flt3-/- and Flt3l-/- mice. J Exp Med. 2018;215:1417-1435 pubmed publisher
Huang L, Nazarova E, Tan S, Liu Y, Russell D. Growth of Mycobacterium tuberculosis in vivo segregates with host macrophage metabolism and ontogeny. J Exp Med. 2018;215:1135-1152 pubmed publisher
Hwang M, Bergmann C. Alpha/Beta Interferon (IFN-?/?) Signaling in Astrocytes Mediates Protection against Viral Encephalomyelitis and Regulates IFN-?-Dependent Responses. J Virol. 2018;92: pubmed publisher
Westhorpe C, Norman M, Hall P, Snelgrove S, Finsterbusch M, Li A, et al. Effector CD4+ T cells recognize intravascular antigen presented by patrolling monocytes. Nat Commun. 2018;9:747 pubmed publisher
Böttcher J, Bonavita E, Chakravarty P, Blees H, Cabeza Cabrerizo M, Sammicheli S, et al. NK Cells Stimulate Recruitment of cDC1 into the Tumor Microenvironment Promoting Cancer Immune Control. Cell. 2018;172:1022-1037.e14 pubmed publisher
Linehan J, Harrison O, Han S, Byrd A, Vujkovic Cvijin I, Villarino A, et al. Non-classical Immunity Controls Microbiota Impact on Skin Immunity and Tissue Repair. Cell. 2018;172:784-796.e18 pubmed publisher
Czimmerer Z, Dániel B, Horvath A, Rückerl D, Nagy G, Kiss M, et al. The Transcription Factor STAT6 Mediates Direct Repression of Inflammatory Enhancers and Limits Activation of Alternatively Polarized Macrophages. Immunity. 2018;48:75-90.e6 pubmed publisher
Georgieva M, Sia J, Bizzell E, Madan Lala R, Rengarajan J. Mycobacterium tuberculosis GroEL2 Modulates Dendritic Cell Responses. Infect Immun. 2018;86: pubmed publisher
Quatrini L, Wieduwild E, Guia S, Bernat C, Glaichenhaus N, Vivier E, et al. Host resistance to endotoxic shock requires the neuroendocrine regulation of group 1 innate lymphoid cells. J Exp Med. 2017;214:3531-3541 pubmed publisher
Jang J, Li J, Gambini L, Batugedara H, Sati S, Lazar M, et al. Human resistin protects against endotoxic shock by blocking LPS-TLR4 interaction. Proc Natl Acad Sci U S A. 2017;114:E10399-E10408 pubmed publisher
De Feo D, Merlini A, Brambilla E, Ottoboni L, Laterza C, Menon R, et al. Neural precursor cell-secreted TGF-β2 redirects inflammatory monocyte-derived cells in CNS autoimmunity. J Clin Invest. 2017;127:3937-3953 pubmed publisher
Jung K, Heishi T, Incio J, Huang Y, Beech E, Pinter M, et al. Targeting CXCR4-dependent immunosuppressive Ly6Clow monocytes improves antiangiogenic therapy in colorectal cancer. Proc Natl Acad Sci U S A. 2017;114:10455-10460 pubmed publisher
Giampazolias E, Zunino B, Dhayade S, Bock F, Cloix C, Cao K, et al. Mitochondrial permeabilization engages NF-κB-dependent anti-tumour activity under caspase deficiency. Nat Cell Biol. 2017;19:1116-1129 pubmed publisher
Savage A, Liang H, Locksley R. The Development of Steady-State Activation Hubs between Adult LTi ILC3s and Primed Macrophages in Small Intestine. J Immunol. 2017;199:1912-1922 pubmed publisher
Percopo C, Ma M, Rosenberg H. Administration of immunobiotic Lactobacillus plantarum delays but does not prevent lethal pneumovirus infection in Rag1-/- mice. J Leukoc Biol. 2017;102:905-913 pubmed publisher
Shrestha B, You D, Saravia J, Siefker D, Jaligama S, Lee G, et al. IL-4R? on dendritic cells in neonates and Th2 immunopathology in respiratory syncytial virus infection. J Leukoc Biol. 2017;102:153-161 pubmed publisher
Stacey M, Clare S, Clement M, Marsden M, Abdul Karim J, Kane L, et al. The antiviral restriction factor IFN-induced transmembrane protein 3 prevents cytokine-driven CMV pathogenesis. J Clin Invest. 2017;127:1463-1474 pubmed publisher
Cebrián C, Zucca F, Mauri P, Steinbeck J, Studer L, Scherzer C, et al. MHC-I expression renders catecholaminergic neurons susceptible to T-cell-mediated degeneration. Nat Commun. 2014;5:3633 pubmed publisher
Bachstetter A, Webster S, Van Eldik L, Cambi F. Clinically relevant intronic splicing enhancer mutation in myelin proteolipid protein leads to progressive microglia and astrocyte activation in white and gray matter regions of the brain. J Neuroinflammation. 2013;10:146 pubmed publisher
Ginhoux F, Collin M, Bogunovic M, Abel M, Leboeuf M, Helft J, et al. Blood-derived dermal langerin+ dendritic cells survey the skin in the steady state. J Exp Med. 2007;204:3133-46 pubmed
Nagamachi M, Sakata D, Kabashima K, Furuyashiki T, Murata T, Segi Nishida E, et al. Facilitation of Th1-mediated immune response by prostaglandin E receptor EP1. J Exp Med. 2007;204:2865-74 pubmed
Purton J, Tan J, Rubinstein M, Kim D, Sprent J, Surh C. Antiviral CD4+ memory T cells are IL-15 dependent. J Exp Med. 2007;204:951-61 pubmed
Wang Q, McLoughlin R, Cobb B, Charrel Dennis M, Zaleski K, Golenbock D, et al. A bacterial carbohydrate links innate and adaptive responses through Toll-like receptor 2. J Exp Med. 2006;203:2853-63 pubmed
Bhattacharya D, Rossi D, Bryder D, Weissman I. Purified hematopoietic stem cell engraftment of rare niches corrects severe lymphoid deficiencies without host conditioning. J Exp Med. 2006;203:73-85 pubmed
Kallies A, Hasbold J, Tarlinton D, Dietrich W, Corcoran L, Hodgkin P, et al. Plasma cell ontogeny defined by quantitative changes in blimp-1 expression. J Exp Med. 2004;200:967-77 pubmed
Hendriks J, Xiao Y, Borst J. CD27 promotes survival of activated T cells and complements CD28 in generation and establishment of the effector T cell pool. J Exp Med. 2003;198:1369-80 pubmed
Wilson A, MacDonald H, Radtke F. Notch 1-deficient common lymphoid precursors adopt a B cell fate in the thymus. J Exp Med. 2001;194:1003-12 pubmed
Felix N, Brickey W, Griffiths R, Zhang J, van Kaer L, Coffman T, et al. H2-DMalpha(-/-) mice show the importance of major histocompatibility complex-bound peptide in cardiac allograft rejection. J Exp Med. 2000;192:31-40 pubmed
product information
Cat.# :
556999
Brand :
BD Pharmingen
Name :
I-A/I-E
Format :
Purified
Clone :
M5/114.15.2 (also known as M5/114
Isotype :
Rat IgG 2b
React :
Ms
Conc :
0.5 mg/ml
Apps :
FCM
Size :
0.5 mg
Status :
RUO
List Price :
245.00 USD
more info or order :
company information