product summary
company name :
BD Biosciences
other brands :
Transduction Laboratories, PharMingen, Difco
product type :
antibody
product name :
p21
catalog :
556430
quantity :
0.1 mg
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
SX118
reactivity :
human, mouse, rat
application :
western blot, immunohistochemistry, immunocytochemistry, immunoprecipitation, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, other
more info or order :
citations: 48
Published Application/Species/Sample/DilutionReference
  • western blot; mouse; 1:1000; loading ...; fig 6f
Gao X, Chen H, Liu J, Shen S, Wang Q, Clement T, et al. The REGγ-Proteasome Regulates Spermatogenesis Partially by P53-PLZF Signaling. Stem Cell Reports. 2019;13:559-571 pubmed publisher
  • western blot; mouse; loading ...; fig 3e
Zhao Y, Tan M, Liu X, Xiong X, Sun Y. Inactivation of ribosomal protein S27-like confers radiosensitivity via the Mdm2-p53 and Mdm2-MRN-ATM axes. Cell Death Dis. 2018;9:145 pubmed publisher
  • western blot; human; loading ...; fig 6
Lee T, Pelletier J. Dependence of p53-deficient cells on the DHX9 DExH-box helicase. Oncotarget. 2017;8:30908-30921 pubmed publisher
  • western blot; human; loading ...; fig 6a
Yuan H, Tan B, Gao S. Tenovin-6 impairs autophagy by inhibiting autophagic flux. Cell Death Dis. 2017;8:e2608 pubmed publisher
  • immunohistochemistry; mouse; 1:1000; loading ...; fig 7h
  • western blot; human; 1:2000; loading ...; fig 3g
Xu J, Zhou W, Yang F, Chen G, Li H, Zhao Y, et al. The β-TrCP-FBXW2-SKP2 axis regulates lung cancer cell growth with FBXW2 acting as a tumour suppressor. Nat Commun. 2017;8:14002 pubmed publisher
  • western blot; human; 1:500; loading ...; fig 6,7d
Marquez Vilendrer S, Thompson K, Lu L, Reisman D. Mechanism of BRG1 silencing in primary cancers. Oncotarget. 2016;7:56153-56169 pubmed publisher
  • western blot; human; fig 1
Hampp S, Kiessling T, Buechle K, Mansilla S, Thomale J, Rall M, et al. DNA damage tolerance pathway involving DNA polymerase ? and the tumor suppressor p53 regulates DNA replication fork progression. Proc Natl Acad Sci U S A. 2016;113:E4311-9 pubmed publisher
  • western blot; mouse; fig 3
Ho T, Guilbaud G, Blow J, Sale J, Watson C. The KRAB Zinc Finger Protein Roma/Zfp157 Is a Critical Regulator of Cell-Cycle Progression and Genomic Stability. Cell Rep. 2016;15:724-734 pubmed publisher
  • western blot; mouse; fig 3
He D, Xiang J, Li B, Liu H. The dynamic behavior of Ect2 in response to DNA damage. Sci Rep. 2016;6:24504 pubmed publisher
  • western blot; human; fig 3a
Garcia C, Videla Richardson G, Dimopoulos N, Fernandez Espinosa D, Miriuka S, Sevlever G, et al. Human Pluripotent Stem Cells and Derived Neuroprogenitors Display Differential Degrees of Susceptibility to BH3 Mimetics ABT-263, WEHI-539 and ABT-199. PLoS ONE. 2016;11:e0152607 pubmed publisher
  • western blot; mouse; fig s1
Barroso González J, Auclair S, Luan S, Thomas L, Atkins K, Aslan J, et al. PACS-2 mediates the ATM and NF-κB-dependent induction of anti-apoptotic Bcl-xL in response to DNA damage. Cell Death Differ. 2016;23:1448-57 pubmed publisher
  • western blot; human; loading ...; fig 4e
Niopek D, Wehler P, Roensch J, Eils R, Di Ventura B. Optogenetic control of nuclear protein export. Nat Commun. 2016;7:10624 pubmed publisher
  • other; human; loading ...; fig st1
Kanderová V, Kuzilkova D, Stuchly J, Vaskova M, Brdicka T, Fiser K, et al. High-resolution Antibody Array Analysis of Childhood Acute Leukemia Cells. Mol Cell Proteomics. 2016;15:1246-61 pubmed publisher
  • western blot; human; fig 2
Marazita M, Dugour A, Marquioni Ramella M, Figueroa J, Suburo A. Oxidative stress-induced premature senescence dysregulates VEGF and CFH expression in retinal pigment epithelial cells: Implications for Age-related Macular Degeneration. Redox Biol. 2016;7:78-87 pubmed publisher
  • western blot; human; 1:1000; fig 4b
Hu D, Gur M, Zhou Z, Gamper A, Hung M, Fujita N, et al. Interplay between arginine methylation and ubiquitylation regulates KLF4-mediated genome stability and carcinogenesis. Nat Commun. 2015;6:8419 pubmed publisher
  • western blot; human; fig 11
Daou S, Hammond Martel I, Mashtalir N, Barbour H, Gagnon J, Iannantuono N, et al. The BAP1/ASXL2 Histone H2A Deubiquitinase Complex Regulates Cell Proliferation and Is Disrupted in Cancer. J Biol Chem. 2015;290:28643-63 pubmed publisher
  • western blot; mouse; fig s3
Xie C, Wei D, Zhao L, Marchetto S, Mei L, Borg J, et al. Erbin is a novel substrate of the Sag-βTrCP E3 ligase that regulates KrasG12D-induced skin tumorigenesis. J Cell Biol. 2015;209:721-37 pubmed publisher
  • western blot; mouse; 1:2000; fig 3
Cheedipudi S, Puri D, Saleh A, Gala H, Rumman M, Pillai M, et al. A fine balance: epigenetic control of cellular quiescence by the tumor suppressor PRDM2/RIZ at a bivalent domain in the cyclin a gene. Nucleic Acids Res. 2015;43:6236-56 pubmed publisher
  • western blot; human
Yamauchi T, Nishiyama M, Moroishi T, Yumimoto K, Nakayama K. MDM2 mediates nonproteolytic polyubiquitylation of the DEAD-Box RNA helicase DDX24. Mol Cell Biol. 2014;34:3321-40 pubmed publisher
  • western blot; human; fig 2
Hayashi A, Suenaga N, Shiomi Y, Nishitani H. PCNA-dependent ubiquitination of Cdt1 and p21 in mammalian cells. Methods Mol Biol. 2014;1170:367-82 pubmed publisher
  • western blot; rat; 1:1000
Borkham Kamphorst E, Schaffrath C, Van De Leur E, Haas U, Tihaa L, Meurer S, et al. The anti-fibrotic effects of CCN1/CYR61 in primary portal myofibroblasts are mediated through induction of reactive oxygen species resulting in cellular senescence, apoptosis and attenuated TGF-? signaling. Biochim Biophys Acta. 2014;1843:902-14 pubmed publisher
  • western blot; mouse
Brochier C, Dennis G, Rivieccio M, McLaughlin K, Coppola G, Ratan R, et al. Specific acetylation of p53 by HDAC inhibition prevents DNA damage-induced apoptosis in neurons. J Neurosci. 2013;33:8621-32 pubmed publisher
Kaur A, Lim J, Sepramaniam S, Patnaik S, Harmston N, Lee M, et al. WNT inhibition creates a BRCA-like state in Wnt-addicted cancer. EMBO Mol Med. 2021;13:e13349 pubmed publisher
Crochemore C, Fernandez Molina C, Montagne B, Salles A, Ricchetti M. CSB promoter downregulation via histone H3 hypoacetylation is an early determinant of replicative senescence. Nat Commun. 2019;10:5576 pubmed publisher
Zhou Z, Feng Z, Hu D, Yang P, Gur M, Bahar I, et al. A novel small-molecule antagonizes PRMT5-mediated KLF4 methylation for targeted therapy. EBioMedicine. 2019;: pubmed publisher
Aubrecht T, Faden A, Sabirzhanov B, Glaser E, Roelofs B, Polster B, et al. Comparing effects of CDK inhibition and E2F1/2 ablation on neuronal cell death pathways in vitro and after traumatic brain injury. Cell Death Dis. 2018;9:1121 pubmed publisher
Osei Kuffour E, Schott K, Jaguva Vasudevan A, Holler J, Schulz W, Lang P, et al. USP18 (UBP43) Abrogates p21-Mediated Inhibition of HIV-1. J Virol. 2018;92: pubmed publisher
Peters D, Radine C, Reese A, Budach W, Sohn D, Janicke R. The DEAD-box RNA helicase DDX41 is a novel repressor of p21WAF1/CIP1 mRNA translation. J Biol Chem. 2017;292:8331-8341 pubmed publisher
Ge X, Chen S, Liu M, Liang T, Liu C. Evodiamine inhibits PDGF?BB?induced proliferation of rat vascular smooth muscle cells through the suppression of cell cycle progression and oxidative stress. Mol Med Rep. 2016;14:4551-4558 pubmed publisher
Beer A, Zenzmaier C, Schreinlechner M, Haas J, Dietrich M, Herz J, et al. Expression of a recombinant full-length LRP1B receptor in human non-small cell lung cancer cells confirms the postulated growth-suppressing function of this large LDL receptor family member. Oncotarget. 2016;7:68721-68733 pubmed publisher
Menendez D, Lowe J, Snipe J, Resnick M. Ligand dependent restoration of human TLR3 signaling and death in p53 mutant cells. Oncotarget. 2016;7:61630-61642 pubmed publisher
Gu Y, Bouwman P, Greco D, Saarela J, Yadav B, Jonkers J, et al. Suppression of BRCA1 sensitizes cells to proteasome inhibitors. Cell Death Dis. 2014;5:e1580 pubmed publisher
Lim H, Xie L, Zhang W, Li R, Chen Z, Wu G, et al. Ribosomal S6 Kinase 2 (RSK2) maintains genomic stability by activating the Atm/p53-dependent DNA damage pathway. PLoS ONE. 2013;8:e74334 pubmed publisher
Greussing R, Hackl M, Charoentong P, Pauck A, Monteforte R, Cavinato M, et al. Identification of microRNA-mRNA functional interactions in UVB-induced senescence of human diploid fibroblasts. BMC Genomics. 2013;14:224 pubmed publisher
Ma P, Schultz R. Histone deacetylase 2 (HDAC2) regulates chromosome segregation and kinetochore function via H4K16 deacetylation during oocyte maturation in mouse. PLoS Genet. 2013;9:e1003377 pubmed publisher
Yehezkel S, Shaked R, Sagie S, Berkovitz R, Shachar Bener H, Segev Y, et al. Characterization and rescue of telomeric abnormalities in ICF syndrome type I fibroblasts. Front Oncol. 2013;3:35 pubmed publisher
Yang Y, Durando M, Smith Roe S, Sproul C, Greenwalt A, Kaufmann W, et al. Cell cycle stage-specific roles of Rad18 in tolerance and repair of oxidative DNA damage. Nucleic Acids Res. 2013;41:2296-312 pubmed publisher
Mackenzie Ross A, Cook M, Chong H, Hossain M, Pandha H, Bennett D. Senescence evasion in melanoma progression: uncoupling of DNA-damage signaling from p53 activation and p21 expression. Pigment Cell Melanoma Res. 2013;26:226-35 pubmed publisher
To K, Pajovic S, Gallie B, Thériault B. Regulation of p14ARF expression by miR-24: a potential mechanism compromising the p53 response during retinoblastoma development. BMC Cancer. 2012;12:69 pubmed publisher
Gremel G, Ryan D, Rafferty M, Lanigan F, Hegarty S, Lavelle M, et al. Functional and prognostic relevance of the homeobox protein MSX2 in malignant melanoma. Br J Cancer. 2011;105:565-74 pubmed publisher
Korfali N, Srsen V, Waterfall M, Batrakou D, Pekovic V, Hutchison C, et al. A flow cytometry-based screen of nuclear envelope transmembrane proteins identifies NET4/Tmem53 as involved in stress-dependent cell cycle withdrawal. PLoS ONE. 2011;6:e18762 pubmed publisher
Vilas Zornoza A, Agirre X, Martín Palanco V, Martin Subero J, San Jose Eneriz E, Garate L, et al. Frequent and simultaneous epigenetic inactivation of TP53 pathway genes in acute lymphoblastic leukemia. PLoS ONE. 2011;6:e17012 pubmed publisher
Xu B, Gerin I, Miao H, Vu Phan D, Johnson C, Xu R, et al. Multiple roles for the non-coding RNA SRA in regulation of adipogenesis and insulin sensitivity. PLoS ONE. 2010;5:e14199 pubmed publisher
Junttila M, Karnezis A, Garcia D, Madriles F, Kortlever R, Rostker F, et al. Selective activation of p53-mediated tumour suppression in high-grade tumours. Nature. 2010;468:567-71 pubmed publisher
Kashiwagi Y, Kato N, Sassa T, Nishitsuka K, Yamamoto T, Takamura H, et al. Cotylenin A inhibits cell proliferation and induces apoptosis and PAX6 mRNA transcripts in retinoblastoma cell lines. Mol Vis. 2010;16:970-82 pubmed
Zhang M, Zhang Z, Fu J, Yang Y, Yun J. Correlation between expression of p53, p21/WAF1, and MDM2 proteins and their prognostic significance in primary hepatocellular carcinoma. J Transl Med. 2009;7:110 pubmed publisher
Campeau E, Ruhl V, Rodier F, Smith C, Rahmberg B, FUSS J, et al. A versatile viral system for expression and depletion of proteins in mammalian cells. PLoS ONE. 2009;4:e6529 pubmed publisher
Rodier F, Coppe J, Patil C, Hoeijmakers W, Muñoz D, Raza S, et al. Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion. Nat Cell Biol. 2009;11:973-9 pubmed publisher
product information
Cat.# :
556430
Brand :
BD Pharmingen
Name :
p21
Format :
Purified
Clone :
SX118
Isotype :
Ms IgG 1
React :
Hu , Ms , Rat
Conc :
0.5 mg/ml
Apps :
IF , IHC(Fr) , IHC(P) , IP , WB
Size :
0.1 mg
Status :
RUO
more info or order :
company information