product summary
company name :
BD Biosciences
other brands :
Transduction Laboratories, PharMingen, Difco
product type :
antibody
product name :
IL-17A
catalog :
555068
quantity :
0.5 mg
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
TC11-18H10
reactivity :
human, mouse
application :
western blot, ELISA, immunocytochemistry, flow cytometry, other
more info or order :
citations: 64
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; 1:200; loading ...; fig 5b, 5d, s5a
Moreira T, Mangani D, Cox L, Leibowitz J, Lobo E, Oliveira M, et al. PD-L1+ and XCR1+ dendritic cells are region-specific regulators of gut homeostasis. Nat Commun. 2021;12:4907 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 5f
Yang C, Kwon D, Kim M, Im S, Lee Y. Commensal Microbiome Expands Tγδ17 Cells in the Lung and Promotes Particulate Matter-Induced Acute Neutrophilia. Front Immunol. 2021;12:645741 pubmed publisher
  • ELISA; mouse; loading ...; fig 5
Akgul A, Maddaloni M, Jun S, Nelson A, Odreman V, Hoffman C, et al. Stimulation of regulatory T cells with Lactococcus lactis expressing enterotoxigenic E. coli colonization factor antigen 1 retains salivary flow in a genetic model of Sjögren's syndrome. Arthritis Res Ther. 2021;23:99 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2a, 3b
Horiuchi H, Parajuli B, Komiya H, Ogawa Y, Jin S, Takahashi K, et al. Interleukin-19 Abrogates Experimental Autoimmune Encephalomyelitis by Attenuating Antigen-Presenting Cell Activation. Front Immunol. 2021;12:615898 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1g
Harbour S, DiToro D, Witte S, Zindl C, Gao M, Schoeb T, et al. TH17 cells require ongoing classic IL-6 receptor signaling to retain transcriptional and functional identity. Sci Immunol. 2020;5: pubmed publisher
  • flow cytometry; mouse; fig 3c
Cheng M, Chen Y, Huang D, Chen W, Xu W, Chen Y, et al. Intrinsically altered lung-resident γδT cells control lung melanoma by producing interleukin-17A in the elderly. Aging Cell. 2020;19:e13099 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2c
Kotov J, Kotov D, Linehan J, Bardwell V, Gearhart M, Jenkins M. BCL6 corepressor contributes to Th17 cell formation by inhibiting Th17 fate suppressors. J Exp Med. 2019;216:1450-1464 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1e
Qu J, Li L, Xie H, Zhang X, Yang Q, Qiu H, et al. TLR3 Modulates the Response of NK Cells against Schistosoma japonicum. J Immunol Res. 2018;2018:7519856 pubmed publisher
  • flow cytometry; mouse; fig 2c
Muschaweckh A, Petermann F, Korn T. IL-1? and IL-23 Promote Extrathymic Commitment of CD27+CD122- ?? T Cells to ??T17 Cells. J Immunol. 2017;199:2668-2679 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 8a
Jiang X, Park C, Geddes Sweeney J, Yoo M, Gaide O, Kupper T. Dermal ?? T Cells Do Not Freely Re-Circulate Out of Skin and Produce IL-17 to Promote Neutrophil Infiltration during Primary Contact Hypersensitivity. PLoS ONE. 2017;12:e0169397 pubmed publisher
  • ELISA; mouse; loading ...; fig 3b
Okuyama H, Tominaga A, Fukuoka S, Taguchi T, Kusumoto Y, Ono S. Spirulina lipopolysaccharides inhibit tumor growth in a Toll-like receptor 4-dependent manner by altering the cytokine milieu from interleukin-17/interleukin-23 to interferon-?. Oncol Rep. 2017;37:684-694 pubmed publisher
  • flow cytometry; mouse; 1:100; loading ...; fig s4a
Griffiths K, Ahmed M, Das S, Gopal R, Horne W, Connell T, et al. Targeting dendritic cells to accelerate T-cell activation overcomes a bottleneck in tuberculosis vaccine efficacy. Nat Commun. 2016;7:13894 pubmed publisher
  • flow cytometry; mouse; fig 5b
Parsa R, Lund H, Georgoudaki A, Zhang X, Ortlieb Guerreiro Cacais A, Grommisch D, et al. BAFF-secreting neutrophils drive plasma cell responses during emergency granulopoiesis. J Exp Med. 2016;213:1537-53 pubmed publisher
  • flow cytometry; mouse
Keil M, Sonner J, Lanz T, Oezen I, Bunse T, Bittner S, et al. General control non-derepressible 2 (GCN2) in T cells controls disease progression of autoimmune neuroinflammation. J Neuroimmunol. 2016;297:117-26 pubmed publisher
  • flow cytometry; mouse; fig 1, 2
Kim J, Choi Y, Lee B, Song M, Ban C, Kim J, et al. Programmed cell death ligand 1 alleviates psoriatic inflammation by suppressing IL-17A production from programmed cell death 1-high T cells. J Allergy Clin Immunol. 2016;137:1466-1476.e3 pubmed publisher
  • flow cytometry; mouse
Luo C, Liao W, Dadi S, Toure A, Li M. Graded Foxo1 activity in Treg cells differentiates tumour immunity from spontaneous autoimmunity. Nature. 2016;529:532-6 pubmed publisher
  • flow cytometry; mouse; fig 3
Verma S, Weiskopf D, Gupta A, McDonald B, Peters B, Sette A, et al. Cytomegalovirus-Specific CD4 T Cells Are Cytolytic and Mediate Vaccine Protection. J Virol. 2016;90:650-8 pubmed publisher
  • flow cytometry; mouse; fig 5b
Nakatsukasa H, Zhang D, Maruyama T, Chen H, Cui K, Ishikawa M, et al. The DNA-binding inhibitor Id3 regulates IL-9 production in CD4(+) T cells. Nat Immunol. 2015;16:1077-84 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1a
Benevides L, da Fonseca D, Donate P, Tiezzi D, De Carvalho D, de Andrade J, et al. IL17 Promotes Mammary Tumor Progression by Changing the Behavior of Tumor Cells and Eliciting Tumorigenic Neutrophils Recruitment. Cancer Res. 2015;75:3788-99 pubmed publisher
  • western blot; mouse; 1:100; fig 5,6
Hsiao H, Hsu T, Liu W, Hsieh W, Chou T, Wu Y, et al. Deltex1 antagonizes HIF-1α and sustains the stability of regulatory T cells in vivo. Nat Commun. 2015;6:6353 pubmed publisher
  • flow cytometry; mouse; fig s5
Zhang Y, Wu B, Metelli A, Thaxton J, Hong F, Rachidi S, et al. GP96 is a GARP chaperone and controls regulatory T cell functions. J Clin Invest. 2015;125:859-69 pubmed publisher
  • flow cytometry; mouse
Rutz S, Kayagaki N, Phung Q, Eidenschenk C, Noubade R, Wang X, et al. Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells. Nature. 2015;518:417-21 pubmed publisher
  • flow cytometry; mouse; fig 8
Frossard C, Asigbetse K, Burger D, Eigenmann P. Gut T cell receptor-γδ(+) intraepithelial lymphocytes are activated selectively by cholera toxin to break oral tolerance in mice. Clin Exp Immunol. 2015;180:118-30 pubmed publisher
  • flow cytometry; mouse; fig 3
Nakamura M, Shibata K, Hatano S, Sato T, Ohkawa Y, Yamada H, et al. A genome-wide analysis identifies a notch-RBP-Jκ-IL-7Rα axis that controls IL-17-producing γδ T cell homeostasis in mice. J Immunol. 2015;194:243-51 pubmed publisher
  • flow cytometry; mouse
Škrnjug I, Guzmán C, Rueckert C, Ruecker C. Cyclic GMP-AMP displays mucosal adjuvant activity in mice. PLoS ONE. 2014;9:e110150 pubmed publisher
  • flow cytometry; mouse; fig 1
Geem D, Medina Contreras O, McBride M, Newberry R, Koni P, Denning T. Specific microbiota-induced intestinal Th17 differentiation requires MHC class II but not GALT and mesenteric lymph nodes. J Immunol. 2014;193:431-8 pubmed publisher
  • flow cytometry; mouse
Pick J, Arra A, Lingel H, Hegel J, Huber M, Nishanth G, et al. CTLA-4 (CD152) enhances the Tc17 differentiation program. Eur J Immunol. 2014;44:2139-52 pubmed publisher
  • flow cytometry; mouse
Chan I, Jain R, Tessmer M, Gorman D, Mangadu R, Sathe M, et al. Interleukin-23 is sufficient to induce rapid de novo gut tumorigenesis, independent of carcinogens, through activation of innate lymphoid cells. Mucosal Immunol. 2014;7:842-56 pubmed publisher
  • other; mouse; fig 6c
Nakae S, Iwakura Y, Suto H, Galli S. Phenotypic differences between Th1 and Th17 cells and negative regulation of Th1 cell differentiation by IL-17. J Leukoc Biol. 2007;81:1258-68 pubmed
Miura S, Watanabe Y, Saigusa R, Yamashita T, Nakamura K, Hirabayashi M, et al. Fli1 deficiency suppresses RALDH1 activity of dermal dendritic cells and related induction of regulatory T cells: a possible role in scleroderma. Arthritis Res Ther. 2021;23:137 pubmed publisher
Shu L, Zhong L, Xiao Y, Wu X, Liu Y, Jiang X, et al. Neutrophil elastase triggers the development of autoimmune diabetes by exacerbating innate immune responses in pancreatic islets of non-obese diabetic mice. Clin Sci (Lond). 2020;134:1679-1696 pubmed publisher
Álvarez Salamero C, Castillo González R, Pastor Fernández G, Mariblanca I, Pino J, Cibrian D, et al. IL-23 signaling regulation of pro-inflammatory T-cell migration uncovered by phosphoproteomics. PLoS Biol. 2020;18:e3000646 pubmed publisher
Sorini C, Cosorich I, Lo Conte M, De Giorgi L, Facciotti F, Lucianò R, et al. Loss of gut barrier integrity triggers activation of islet-reactive T cells and autoimmune diabetes. Proc Natl Acad Sci U S A. 2019;: pubmed publisher
Graham K, Werner B, Moyer K, Patton A, Krois C, Yoo H, et al. DGAT1 inhibits retinol-dependent regulatory T cell formation and mediates autoimmune encephalomyelitis. Proc Natl Acad Sci U S A. 2019;116:3126-3135 pubmed publisher
Karrich J, Romera Hernandez M, Papazian N, Veenbergen S, Cornelissen F, Aparicio Domingo P, et al. Expression of Plet1 controls interstitial migration of murine small intestinal dendritic cells. Eur J Immunol. 2019;49:290-301 pubmed publisher
Amir M, Chaudhari S, Wang R, Campbell S, Mosure S, Chopp L, et al. REV-ERBα Regulates TH17 Cell Development and Autoimmunity. Cell Rep. 2018;25:3733-3749.e8 pubmed publisher
Nakanishi Y, Duran A, L Hermitte A, Shelton P, Nakanishi N, Reina Campos M, et al. Simultaneous Loss of Both Atypical Protein Kinase C Genes in the Intestinal Epithelium Drives Serrated Intestinal Cancer by Impairing Immunosurveillance. Immunity. 2018;49:1132-1147.e7 pubmed publisher
Grohmann M, Wiede F, Dodd G, Gurzov E, Ooi G, Butt T, et al. Obesity Drives STAT-1-Dependent NASH and STAT-3-Dependent HCC. Cell. 2018;175:1289-1306.e20 pubmed publisher
Gopal R, Lee B, McHugh K, Rich H, Ramanan K, Mandalapu S, et al. STAT2 Signaling Regulates Macrophage Phenotype During Influenza and Bacterial Super-Infection. Front Immunol. 2018;9:2151 pubmed publisher
Napier R, Lee E, Vance E, Snow P, Samson K, Dawson C, et al. Nod2 Deficiency Augments Th17 Responses and Exacerbates Autoimmune Arthritis. J Immunol. 2018;201:1889-1898 pubmed publisher
Gresnigt M, Cunha C, Jaeger M, Gonçalves S, Malireddi R, Ammerdorffer A, et al. Genetic deficiency of NOD2 confers resistance to invasive aspergillosis. Nat Commun. 2018;9:2636 pubmed publisher
Tanaka S, Jiang Y, Martinez G, Tanaka K, Yan X, Kurosaki T, et al. Trim33 mediates the proinflammatory function of Th17 cells. J Exp Med. 2018;215:1853-1868 pubmed publisher
Zhu J, Liu J, Liu Z, Wu L, Shi M, Zhang J, et al. Interleukin-27 Gene Therapy Prevents the Development of Autoimmune Encephalomyelitis but Fails to Attenuate Established Inflammation due to the Expansion of CD11b+Gr-1+ Myeloid Cells. Front Immunol. 2018;9:873 pubmed publisher
Zhao M, Tan Y, Peng Q, Huang C, Guo Y, Liang G, et al. IL-6/STAT3 pathway induced deficiency of RFX1 contributes to Th17-dependent autoimmune diseases via epigenetic regulation. Nat Commun. 2018;9:583 pubmed publisher
Dillen C, Pinsker B, Marusina A, Merleev A, Farber O, Liu H, et al. Clonally expanded γδ T cells protect against Staphylococcus aureus skin reinfection. J Clin Invest. 2018;128:1026-1042 pubmed publisher
Kip E, Staal J, Verstrepen L, Tima H, Terryn S, Romano M, et al. MALT1 Controls Attenuated Rabies Virus by Inducing Early Inflammation and T Cell Activation in the Brain. J Virol. 2018;92: pubmed publisher
Bizzell E, Sia J, Quezada M, Enríquez A, Georgieva M, Rengarajan J. Deletion of BCG Hip1 protease enhances dendritic cell and CD4 T cell responses. J Leukoc Biol. 2018;103:739-748 pubmed publisher
Xu L, Ding W, Stohl L, Zhou X, Azizi S, Chuang E, et al. Regulation of T Helper Cell Responses During Antigen Presentation by Norepinephrine-exposed Endothelial Cells. Immunology. 2017;: pubmed publisher
Malik S, Sadhu S, Elesela S, Pandey R, Chawla A, Sharma D, et al. Transcription factor Foxo1 is essential for IL-9 induction in T helper cells. Nat Commun. 2017;8:815 pubmed publisher
De Feo D, Merlini A, Brambilla E, Ottoboni L, Laterza C, Menon R, et al. Neural precursor cell-secreted TGF-β2 redirects inflammatory monocyte-derived cells in CNS autoimmunity. J Clin Invest. 2017;127:3937-3953 pubmed publisher
Barik S, Ellis J, Cascio J, Miller M, Ukah T, Cattin Roy A, et al. IL-4/IL-13 Heteroreceptor Influences Th17 Cell Conversion and Sensitivity to Regulatory T Cell Suppression To Restrain Experimental Allergic Encephalomyelitis. J Immunol. 2017;199:2236-2248 pubmed publisher
Bergmann H, Roth S, Pechloff K, Kiss E, Kuhn S, Heikenwalder M, et al. Card9-dependent IL-1? regulates IL-22 production from group 3 innate lymphoid cells and promotes colitis-associated cancer. Eur J Immunol. 2017;47:1342-1353 pubmed publisher
Ripamonti C, Bishop L, Kovacs J. Pulmonary Interleukin-17-Positive Lymphocytes Increase during Pneumocystis murina Infection but Are Not Required for Clearance of Pneumocystis. Infect Immun. 2017;85: pubmed publisher
Gomez Lopez N, Romero R, Arenas Hernandez M, Schwenkel G, St Louis D, Hassan S, et al. In vivo activation of invariant natural killer T cells induces systemic and local alterations in T-cell subsets prior to preterm birth. Clin Exp Immunol. 2017;189:211-225 pubmed publisher
Ansa Addo E, Zhang Y, Yang Y, Hussey G, Howley B, Salem M, et al. Membrane-organizing protein moesin controls Treg differentiation and antitumor immunity via TGF-β signaling. J Clin Invest. 2017;127:1321-1337 pubmed publisher
Brahmakshatriya V, Kuang Y, Devarajan P, Xia J, Zhang W, Vong A, et al. IL-6 Production by TLR-Activated APC Broadly Enhances Aged Cognate CD4 Helper and B Cell Antibody Responses In Vivo. J Immunol. 2017;198:2819-2833 pubmed publisher
Hao Z, Sheng Y, Duncan G, Li W, Dominguez C, Sylvester J, et al. K48-linked KLF4 ubiquitination by E3 ligase Mule controls T-cell proliferation and cell cycle progression. Nat Commun. 2017;8:14003 pubmed publisher
Li Y, Lu Y, Wang S, Han Z, Zhu F, Ni Y, et al. USP21 prevents the generation of T-helper-1-like Treg cells. Nat Commun. 2016;7:13559 pubmed publisher
Kwong Chung C, Ronchi F, Geuking M. Detrimental effect of systemic antimicrobial CD4+ T-cell reactivity on gut epithelial integrity. Immunology. 2017;150:221-235 pubmed publisher
Uto T, Fukaya T, Takagi H, Arimura K, Nakamura T, Kojima N, et al. Clec4A4 is a regulatory receptor for dendritic cells that impairs inflammation and T-cell immunity. Nat Commun. 2016;7:11273 pubmed publisher
Sánchez González B, García Vázquez F, Farfán Morales J, Jiménez Zamudio L. Increased NHC Cells in the Peritoneal Cavity of Plasmacytoma Susceptible BALB/c Mouse. Mediators Inflamm. 2015;2015:313140 pubmed publisher
Luger D, Silver P, Tang J, Cua D, Chen Z, Iwakura Y, et al. Either a Th17 or a Th1 effector response can drive autoimmunity: conditions of disease induction affect dominant effector category. J Exp Med. 2008;205:799-810 pubmed publisher
Moisan J, Grenningloh R, Bettelli E, Oukka M, Ho I. Ets-1 is a negative regulator of Th17 differentiation. J Exp Med. 2007;204:2825-35 pubmed
Liang S, Tan X, Luxenberg D, Karim R, Dunussi Joannopoulos K, Collins M, et al. Interleukin (IL)-22 and IL-17 are coexpressed by Th17 cells and cooperatively enhance expression of antimicrobial peptides. J Exp Med. 2006;203:2271-9 pubmed
product information
Cat.# :
555068
Brand :
BD Pharmingen
Name :
IL-17A
Format :
Purified
Clone :
TC11-18H10
Isotype :
Rat IgG 1
React :
Ms
Conc :
0.5 mg/ml
Apps :
ELISA Cap. , IC/FCM , Neu
Size :
0.5 mg
Status :
RUO
more info or order :
company information