product summary
company name :
BD Biosciences
other brands :
Transduction Laboratories, PharMingen, Difco
product type :
antibody
product name :
CD4
catalog :
553647
quantity :
0.5 mg
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
H129.19
reactivity :
mouse
application :
immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 58
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - frozen section; mouse; loading ...; fig 2f
Gehlsen U, Stary D, Maass M, Riesner K, Musial G, Stern M, et al. Ocular Graft-versus-Host Disease in a Chemotherapy-Based Minor-Mismatch Mouse Model Features Corneal (Lymph-) Angiogenesis. Int J Mol Sci. 2021;22: pubmed publisher
  • flow cytometry; mouse; loading ...; fig 8b
Grand M, Waqasi M, Demarta Gatsi C, Wei Y, Peronet R, Commere P, et al. Hepatic Inflammation Confers Protective Immunity Against Liver Stages of Malaria Parasite. Front Immunol. 2020;11:585502 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1.25 ug/ml; loading ...; fig 4a
Enríquez Pérez J, Kopecky J, Visse E, Darabi A, Siesjo P. Convection-enhanced delivery of temozolomide and whole cell tumor immunizations in GL261 and KR158 experimental mouse gliomas. BMC Cancer. 2020;20:7 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 2d
Stefani F, Eberstål S, Vergani S, Kristiansen T, Bengzon J. Low-dose irradiated mesenchymal stromal cells break tumor defensive properties in vivo. Int J Cancer. 2018;143:2200-2212 pubmed publisher
  • flow cytometry; mouse; fig s6g
Kaufmann E, Sanz J, Dunn J, Khan N, Mendonça L, Pacis A, et al. BCG Educates Hematopoietic Stem Cells to Generate Protective Innate Immunity against Tuberculosis. Cell. 2018;172:176-190.e19 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3b, 4d
Garaycoechea J, Crossan G, Langevin F, Mulderrig L, Louzada S, Yang F, et al. Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells. Nature. 2018;553:171-177 pubmed publisher
  • flow cytometry; mouse; fig 7
Vaitaitis G, Yussman M, Waid D, Wagner D. Th40 cells (CD4+CD40+ Tcells) drive a more severe form of Experimental Autoimmune Encephalomyelitis than conventional CD4 T cells. PLoS ONE. 2017;12:e0172037 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 5000 ng/ml; loading ...; fig 2f
Yamamura K, Uruno T, Shiraishi A, Tanaka Y, Ushijima M, Nakahara T, et al. The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction. Nat Commun. 2017;8:13946 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2B
Alves da Costa T, Di Gangi R, Thomé R, Barreto Felisbino M, Pires Bonfanti A, Lumi Watanabe Ishikawa L, et al. Severe Changes in Thymic Microenvironment in a Chronic Experimental Model of Paracoccidioidomycosis. PLoS ONE. 2016;11:e0164745 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 10 ug/ml; loading ...; fig 2h
Coursey T, Bian F, Zaheer M, Pflugfelder S, Volpe E, de Paiva C. Age-related spontaneous lacrimal keratoconjunctivitis is accompanied by dysfunctional T regulatory cells. Mucosal Immunol. 2017;10:743-756 pubmed publisher
  • flow cytometry; mouse; 1:200; loading ...; fig 3g
Ruhland M, Loza A, Capietto A, Luo X, Knolhoff B, Flanagan K, et al. Stromal senescence establishes an immunosuppressive microenvironment that drives tumorigenesis. Nat Commun. 2016;7:11762 pubmed publisher
  • immunohistochemistry - frozen section; mouse; fig 4b
Jiang Y, Gao Q, Wang L, Guo C, Zhu F, Wang B, et al. Deficiency of programmed cell death 4 results in increased IL-10 expression by macrophages and thereby attenuates atherosclerosis in hyperlipidemic mice. Cell Mol Immunol. 2016;13:524-34 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 10 ug/ml; fig 2
Bian F, Barbosa F, Corrales R, Pelegrino F, Volpe E, Pflugfelder S, et al. Altered balance of interleukin-13/interferon-gamma contributes to lacrimal gland destruction and secretory dysfunction in CD25 knockout model of Sjögren's syndrome. Arthritis Res Ther. 2015;17:53 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 2.5 ug/ml
Bassi M, Kongsgaard M, Steffensen M, Fenger C, Rasmussen M, Skjødt K, et al. CD8+ T cells complement antibodies in protecting against yellow fever virus. J Immunol. 2015;194:1141-53 pubmed publisher
  • flow cytometry; mouse; fig 5
Pekkonen P, Järviluoma A, Zinovkina N, Cvrljevic A, Prakash S, Westermarck J, et al. KSHV viral cyclin interferes with T-cell development and induces lymphoma through Cdk6 and Notch activation in vivo. Cell Cycle. 2014;13:3670-84 pubmed publisher
  • flow cytometry; mouse; fig 5
Donaldson D, Bradford B, Artis D, Mabbott N. Reciprocal regulation of lymphoid tissue development in the large intestine by IL-25 and IL-23. Mucosal Immunol. 2015;8:582-95 pubmed publisher
  • flow cytometry; mouse; fig 5
Naik E, Webster J, DeVoss J, Liu J, Suriben R, Dixit V. Regulation of proximal T cell receptor signaling and tolerance induction by deubiquitinase Usp9X. J Exp Med. 2014;211:1947-55 pubmed publisher
  • immunocytochemistry; mouse
Rudell J, Borges L, Rudell J, Beck K, Ferns M. Determinants in the ? and ? subunit cytoplasmic loop regulate Golgi trafficking and surface expression of the muscle acetylcholine receptor. J Biol Chem. 2014;289:203-14 pubmed publisher
Jeong S, Jung B, Ahn H, Lee D, Ha J, Noh I, et al. Immunogenic Cell Death Inducing Fluorinated Mitochondria-Disrupting Helical Polypeptide Synergizes with PD-L1 Immune Checkpoint Blockade. Adv Sci (Weinh). 2021;8:2001308 pubmed publisher
Okumura G, Iguchi Manaka A, Murata R, Yamashita Kanemaru Y, Shibuya A, Shibuya K. Tumor-derived soluble CD155 inhibits DNAM-1-mediated antitumor activity of natural killer cells. J Exp Med. 2020;217: pubmed publisher
Bennett J, Singh K, Welle S, Boule L, Lawrence B, Gasiewicz T. Conditional deletion of Ahr alters gene expression profiles in hematopoietic stem cells. PLoS ONE. 2018;13:e0206407 pubmed publisher
Singhal M, Liu X, Inverso D, Jiang K, Dai J, He H, et al. Endothelial cell fitness dictates the source of regenerating liver vasculature. J Exp Med. 2018;215:2497-2508 pubmed publisher
Suryadevara C, Desai R, Abel M, Riccione K, Batich K, Shen S, et al. Temozolomide lymphodepletion enhances CAR abundance and correlates with antitumor efficacy against established glioblastoma. Oncoimmunology. 2018;7:e1434464 pubmed publisher
Vaartjes D, Nandakumar K, Holmdahl R, Raposo B. Increased salt exposure affects both lymphoid and myeloid effector functions, influencing innate-associated disease but not T-cell-associated autoimmunity. Immunology. 2018;: pubmed publisher
Risco A, Martín Serrano M, Barber D, Cuenda A. p38γ and p38δ Are Involved in T Lymphocyte Development. Front Immunol. 2018;9:65 pubmed publisher
Mensink M, Anstee N, Robati M, Schenk R, Herold M, Cory S, et al. Anti-apoptotic A1 is not essential for lymphoma development in Eµ-Myc mice but helps sustain transplanted Eµ-Myc tumour cells. Cell Death Differ. 2018;25:795-806 pubmed publisher
Klocke K, Holmdahl R, Wing K. CTLA-4 expressed by FOXP3+ regulatory T cells prevents inflammatory tissue attack and not T-cell priming in arthritis. Immunology. 2017;152:125-137 pubmed publisher
Nouri Shirazi M, Bible B, Zeng M, Tamjidi S, Bossart G. Phenotyping and comparing the immune cell populations of free-ranging Atlantic bottlenose dolphins (Tursiops truncatus) and dolphins under human care. BMC Vet Res. 2017;13:78 pubmed publisher
Kasahara K, Tanoue T, Yamashita T, Yodoi K, Matsumoto T, Emoto T, et al. Commensal bacteria at the crossroad between cholesterol homeostasis and chronic inflammation in atherosclerosis. J Lipid Res. 2017;58:519-528 pubmed publisher
Damgaard R, Walker J, Marco Casanova P, Morgan N, Titheradge H, Elliott P, et al. The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity. Cell. 2016;166:1215-1230.e20 pubmed publisher
Mandal M, Hamel K, Maienschein Cline M, Tanaka A, Teng G, Tuteja J, et al. Histone reader BRWD1 targets and restricts recombination to the Igk locus. Nat Immunol. 2015;16:1094-103 pubmed publisher
Gillis L, Berry D, Minden M, McGlade C, Barber D. Gads (Grb2-related adaptor downstream of Shc) is required for BCR-ABL-mediated lymphoid leukemia. Leukemia. 2013;27:1666-76 pubmed publisher
Dougan S, Rava P, Hussain M, Blumberg R. MTP regulated by an alternate promoter is essential for NKT cell development. J Exp Med. 2007;204:533-45 pubmed
Tarbell K, Petit L, Zuo X, Toy P, Luo X, Mqadmi A, et al. Dendritic cell-expanded, islet-specific CD4+ CD25+ CD62L+ regulatory T cells restore normoglycemia in diabetic NOD mice. J Exp Med. 2007;204:191-201 pubmed
Ko K, Yamazaki S, Nakamura K, Nishioka T, Hirota K, Yamaguchi T, et al. Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells. J Exp Med. 2005;202:885-91 pubmed
Samy E, Parker L, Sharp C, Tung K. Continuous control of autoimmune disease by antigen-dependent polyclonal CD4+CD25+ regulatory T cells in the regional lymph node. J Exp Med. 2005;202:771-81 pubmed
Yoshitomi H, Sakaguchi N, Kobayashi K, Brown G, Tagami T, Sakihama T, et al. A role for fungal {beta}-glucans and their receptor Dectin-1 in the induction of autoimmune arthritis in genetically susceptible mice. J Exp Med. 2005;201:949-60 pubmed
Setoguchi R, Hori S, Takahashi T, Sakaguchi S. Homeostatic maintenance of natural Foxp3(+) CD25(+) CD4(+) regulatory T cells by interleukin (IL)-2 and induction of autoimmune disease by IL-2 neutralization. J Exp Med. 2005;201:723-35 pubmed
Nishikawa H, Kato T, Tawara I, Saito K, Ikeda H, Kuribayashi K, et al. Definition of target antigens for naturally occurring CD4(+) CD25(+) regulatory T cells. J Exp Med. 2005;201:681-6 pubmed
Ling K, Ottersbach K, van Hamburg J, Oziemlak A, Tsai F, Orkin S, et al. GATA-2 plays two functionally distinct roles during the ontogeny of hematopoietic stem cells. J Exp Med. 2004;200:871-82 pubmed
Tarbell K, Yamazaki S, Olson K, Toy P, Steinman R. CD25+ CD4+ T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes. J Exp Med. 2004;199:1467-77 pubmed
Fujikawa K, Miletic A, Alt F, Faccio R, Brown T, Hoog J, et al. Vav1/2/3-null mice define an essential role for Vav family proteins in lymphocyte development and activation but a differential requirement in MAPK signaling in T and B cells. J Exp Med. 2003;198:1595-608 pubmed
Yamazaki S, Iyoda T, Tarbell K, Olson K, Velinzon K, Inaba K, et al. Direct expansion of functional CD25+ CD4+ regulatory T cells by antigen-processing dendritic cells. J Exp Med. 2003;198:235-47 pubmed
Salama A, Chitnis T, Imitola J, Ansari M, Akiba H, Tushima F, et al. Critical role of the programmed death-1 (PD-1) pathway in regulation of experimental autoimmune encephalomyelitis. J Exp Med. 2003;198:71-8 pubmed
Wuthrich M, Filutowicz H, Warner T, Deepe G, Klein B. Vaccine immunity to pathogenic fungi overcomes the requirement for CD4 help in exogenous antigen presentation to CD8+ T cells: implications for vaccine development in immune-deficient hosts. J Exp Med. 2003;197:1405-16 pubmed
Daniel D, Meyer Morse N, Bergsland E, Dehne K, Coussens L, Hanahan D. Immune enhancement of skin carcinogenesis by CD4+ T cells. J Exp Med. 2003;197:1017-28 pubmed
Hommel M, Kyewski B. Dynamic changes during the immune response in T cell-antigen-presenting cell clusters isolated from lymph nodes. J Exp Med. 2003;197:269-80 pubmed
Graca L, Cobbold S, Waldmann H. Identification of regulatory T cells in tolerated allografts. J Exp Med. 2002;195:1641-6 pubmed
Sasada T, Touma M, Chang H, Clayton L, Wang J, Reinherz E. Involvement of the TCR Cbeta FG loop in thymic selection and T cell function. J Exp Med. 2002;195:1419-31 pubmed
Belkaid Y, Hoffmann K, Mendez S, Kamhawi S, Udey M, Wynn T, et al. The role of interleukin (IL)-10 in the persistence of Leishmania major in the skin after healing and the therapeutic potential of anti-IL-10 receptor antibody for sterile cure. J Exp Med. 2001;194:1497-506 pubmed
Sasada T, Ghendler Y, Neveu J, Lane W, Reinherz E. A naturally processed mitochondrial self-peptide in complex with thymic MHC molecules functions as a selecting ligand for a viral-specific T cell receptor. J Exp Med. 2001;194:883-92 pubmed
Salomon B, Rhee L, Bour Jordan H, Hsin H, Montag A, Soliven B, et al. Development of spontaneous autoimmune peripheral polyneuropathy in B7-2-deficient NOD mice. J Exp Med. 2001;194:677-84 pubmed
Mehling A, Loser K, Varga G, Metze D, Luger T, Schwarz T, et al. Overexpression of CD40 ligand in murine epidermis results in chronic skin inflammation and systemic autoimmunity. J Exp Med. 2001;194:615-28 pubmed
Rodewald H, Waskow C, Haller C. Essential requirement for c-kit and common gamma chain in thymocyte development cannot be overruled by enforced expression of Bcl-2. J Exp Med. 2001;193:1431-7 pubmed
Anderton S, Radu C, Lowrey P, Ward E, Wraith D. Negative selection during the peripheral immune response to antigen. J Exp Med. 2001;193:1-11 pubmed
Takahashi T, Tagami T, Yamazaki S, Uede T, Shimizu J, Sakaguchi N, et al. Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J Exp Med. 2000;192:303-10 pubmed
Nagaoka H, Gonzalez Aseguinolaza G, Tsuji M, Nussenzweig M. Immunization and infection change the number of recombination activating gene (RAG)-expressing B cells in the periphery by altering immature lymphocyte production. J Exp Med. 2000;191:2113-20 pubmed
Korner H, Cretney E, Wilhelm P, Kelly J, Rollinghoff M, Sedgwick J, et al. Tumor necrosis factor sustains the generalized lymphoproliferative disorder (gld) phenotype. J Exp Med. 2000;191:89-96 pubmed
product information
Cat.# :
553647
Brand :
BD Pharmingen
Name :
CD4
Format :
Purified
Clone :
H129.19
Isotype :
Rat IgG 2a
React :
Ms
Conc :
0.5 mg/ml
Apps :
FCM
Size :
0.5 mg
Status :
RUO
more info or order :
company information