product summary
company name :
BD Biosciences
other brands :
Transduction Laboratories, PharMingen, Difco
product type :
antibody
product name :
Mac-3
catalog :
553322
quantity :
0.5 mg
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
M3/84
reactivity :
mouse
application :
immunohistochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 52
Published Application/Species/Sample/DilutionReference
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 2d, 8a
Kettwig M, Ternka K, Wendland K, Krüger D, Zampar S, Schob C, et al. Interferon-driven brain phenotype in a mouse model of RNaseT2 deficient leukoencephalopathy. Nat Commun. 2021;12:6530 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 1l
Rajendran R, Rajendran V, Giraldo Velasquez M, Megalofonou F, Gurski F, Stadelmann C, et al. Oligodendrocyte-Specific Deletion of FGFR1 Reduces Cerebellar Inflammation and Neurodegeneration in MOG35-55-Induced EAE. Int J Mol Sci. 2021;22: pubmed publisher
  • immunohistochemistry; mouse; 2.5 ug/ml; loading ...; fig 2c
Datta M, Staszewski O. Hdac1 and Hdac2 are essential for physiological maturation of a Cx3cr1 expressing subset of T-lymphocytes. BMC Res Notes. 2021;14:135 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:900; loading ...; fig 4g
Yang D, Haemmig S, Zhou H, Pérez Cremades D, Sun X, Chen L, et al. Methotrexate attenuates vascular inflammation through an adenosine-microRNA-dependent pathway. elife. 2021;10: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100; loading ...; fig s10c
Schafflick D, Xu C, Hartlehnert M, Cole M, Schulte Mecklenbeck A, Lautwein T, et al. Integrated single cell analysis of blood and cerebrospinal fluid leukocytes in multiple sclerosis. Nat Commun. 2020;11:247 pubmed publisher
  • immunohistochemistry; mouse; 1:100; loading ...; fig 5a
Johnston J, Angyal A, Bauer R, Hamby S, Suvarna S, Baidžajevas K, et al. Myeloid Tribbles 1 induces early atherosclerosis via enhanced foam cell expansion. Sci Adv. 2019;5:eaax9183 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:900; loading ...; fig s1b
Engelbertsen D, Autio A, Verwilligen R, Depuydt M, Newton G, Rattik S, et al. Increased lymphocyte activation and atherosclerosis in CD47-deficient mice. Sci Rep. 2019;9:10608 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; loading ...; fig 8c
Mentrup T, Theodorou K, Cabrera Cabrera F, Helbig A, Happ K, Gijbels M, et al. Atherogenic LOX-1 signaling is controlled by SPPL2-mediated intramembrane proteolysis. J Exp Med. 2019;: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 8c
Jordão M, Sankowski R, Brendecke S, Sagar -, Locatelli G, Tai Y, et al. Single-cell profiling identifies myeloid cell subsets with distinct fates during neuroinflammation. Science. 2019;363: pubmed publisher
  • immunohistochemistry; mouse; 1:400; loading ...; fig f2s2c
Erwig M, Patzig J, Steyer A, Dibaj P, Heilmann M, Heilmann I, et al. Anillin facilitates septin assembly to prevent pathological outfoldings of central nervous system myelin. elife. 2019;8: pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:30; loading ...; fig 4e
Aarts S, Seijkens T, Kusters P, Van Tiel C, Reiche M, den Toom M, et al. Macrophage CD40 signaling drives experimental autoimmune encephalomyelitis. J Pathol. 2019;247:471-480 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig 8c
Hulsmans M, Sager H, Roh J, Valero Muñoz M, Houstis N, Iwamoto Y, et al. Cardiac macrophages promote diastolic dysfunction. J Exp Med. 2018;215:423-440 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 5a
Hooper A, Alamilla J, Venier R, Gillespie D, Igdoura S. Neuronal pentraxin 1 depletion delays neurodegeneration and extends life in Sandhoff disease mice. Hum Mol Genet. 2017;26:661-673 pubmed publisher
  • immunohistochemistry; mouse; fig 5b
Grootaert M, Schrijvers D, Hermans M, Van Hoof V, De Meyer G, Martinet W. Caspase-3 Deletion Promotes Necrosis in Atherosclerotic Plaques of ApoE Knockout Mice. Oxid Med Cell Longev. 2016;2016:3087469 pubmed
  • immunohistochemistry - paraffin section; mouse; 1:500; loading ...; fig s2e
Goebbels S, Wieser G, Pieper A, Spitzer S, Weege B, Yan K, et al. A neuronal PI(3,4,5)P3-dependent program of oligodendrocyte precursor recruitment and myelination. Nat Neurosci. 2017;20:10-15 pubmed publisher
  • immunohistochemistry; mouse; 1:100; loading ...; fig 6b
Al Sadoun H, Burgess M, Hentges K, Mace K. Enforced Expression of Hoxa3 Inhibits Classical and Promotes Alternative Activation of Macrophages In Vitro and In Vivo. J Immunol. 2016;197:872-84 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; fig 3a
Kramann N, Menken L, Hayardeny L, Hanisch U, Bruck W. Laquinimod prevents cuprizone-induced demyelination independent of Toll-like receptor signaling. Neurol Neuroimmunol Neuroinflamm. 2016;3:e233 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 1
Hochmeister S, Engel O, Adzemovic M, Pekar T, Kendlbacher P, Zeitelhofer M, et al. Lipocalin-2 as an Infection-Related Biomarker to Predict Clinical Outcome in Ischemic Stroke. PLoS ONE. 2016;11:e0154797 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 15 ug/ml; fig 4
Crompton R, Williams H, Ansell D, Campbell L, Holden K, Cruickshank S, et al. Oestrogen promotes healing in a bacterial LPS model of delayed cutaneous wound repair. Lab Invest. 2016;96:439-49 pubmed publisher
  • immunohistochemistry; mouse; fig 8
Grootaert M, da Costa Martins P, Bitsch N, Pintelon I, De Meyer G, Martinet W, et al. Defective autophagy in vascular smooth muscle cells accelerates senescence and promotes neointima formation and atherogenesis. Autophagy. 2015;11:2014-2032 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; fig 2
Sendler M, Beyer G, Mahajan U, Kauschke V, Maertin S, Schurmann C, et al. Complement Component 5 Mediates Development of Fibrosis, via Activation of Stellate Cells, in 2 Mouse Models of Chronic Pancreatitis. Gastroenterology. 2015;149:765-76.e10 pubmed publisher
  • immunohistochemistry - frozen section; mouse
Theotokis P, Kleopa K, Touloumi O, Lagoudaki R, Lourbopoulos A, Nousiopoulou E, et al. Connexin43 and connexin47 alterations after neural precursor cells transplantation in experimental autoimmune encephalomyelitis. Glia. 2015;63:1772-83 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; fig 1
Heinzmann D, Bangert A, Müller A, von Ungern Sternberg S, Emschermann F, Schönberger T, et al. The Novel Extracellular Cyclophilin A (CyPA) - Inhibitor MM284 Reduces Myocardial Inflammation and Remodeling in a Mouse Model of Troponin I -Induced Myocarditis. PLoS ONE. 2015;10:e0124606 pubmed publisher
  • immunohistochemistry; mouse; 1:100
Ressler S, Dang T, Wu S, Tse D, Gilbert B, Vyakarnam A, et al. WFDC1 is a key modulator of inflammatory and wound repair responses. Am J Pathol. 2014;184:2951-64 pubmed publisher
  • flow cytometry; mouse
Bernasconi E, D Angelo F, Michetti P, Velin D. Critical role of the GM-CSF signaling pathway in macrophage pro-repair activities. Pathobiology. 2014;81:183-9 pubmed publisher
  • immunohistochemistry - paraffin section; mouse
Aoshiba K, Tsuji T, Itoh M, Semba S, Yamaguchi K, Nakamura H, et al. A murine model of airway fibrosis induced by repeated naphthalene exposure. Exp Toxicol Pathol. 2014;66:169-77 pubmed publisher
  • immunohistochemistry; mouse
Sastre C, Fernández Laso V, Madrigal Matute J, Munoz Garcia B, Moreno J, Pastor Vargas C, et al. Genetic deletion or TWEAK blocking antibody administration reduce atherosclerosis and enhance plaque stability in mice. J Cell Mol Med. 2014;18:721-34 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:100
Yanez C, Morales A, Yue X, Urakami T, Komatsu M, Järvinen T, et al. Deep vascular imaging in wounds by two-photon fluorescence microscopy. PLoS ONE. 2013;8:e67559 pubmed publisher
Baganha F, de Jong R, Peters E, Voorham W, Jukema J, Delibegovic M, et al. Atorvastatin pleiotropically decreases intraplaque angiogenesis and intraplaque haemorrhage by inhibiting ANGPT2 release and VE-Cadherin internalization. Angiogenesis. 2021;24:567-581 pubmed publisher
Simion V, Zhou H, Haemmig S, Pierce J, Mendes S, Tesmenitsky Y, et al. A macrophage-specific lncRNA regulates apoptosis and atherosclerosis by tethering HuR in the nucleus. Nat Commun. 2020;11:6135 pubmed publisher
Aravani D, Foote K, Figg N, Finigan A, Uryga A, Clarke M, et al. Cytokine regulation of apoptosis-induced apoptosis and apoptosis-induced cell proliferation in vascular smooth muscle cells. Apoptosis. 2020;25:648-662 pubmed publisher
Guo W, Gao R, Zhang W, Ge W, Ren M, Li B, et al. IgE Aggravates the Senescence of Smooth Muscle Cells in Abdominal Aortic Aneurysm by Upregulating LincRNA-p21. Aging Dis. 2019;10:699-710 pubmed publisher
Koenis D, Medzikovic L, van Loenen P, van Weeghel M, Huveneers S, Vos M, et al. Nuclear Receptor Nur77 Limits the Macrophage Inflammatory Response through Transcriptional Reprogramming of Mitochondrial Metabolism. Cell Rep. 2018;24:2127-2140.e7 pubmed publisher
Rothhammer V, Borucki D, Tjon E, Takenaka M, Chao C, Ardura Fabregat A, et al. Microglial control of astrocytes in response to microbial metabolites. Nature. 2018;557:724-728 pubmed publisher
Wang Y, Subramanian M, Yurdagul A, Barbosa Lorenzi V, Cai B, de Juan Sanz J, et al. Mitochondrial Fission Promotes the Continued Clearance of Apoptotic Cells by Macrophages. Cell. 2017;171:331-345.e22 pubmed publisher
Vogel A, Knier B, Lammens K, Kalluri S, Kuhlmann T, Bennett J, et al. Deletional tolerance prevents AQP4-directed autoimmunity in mice. Eur J Immunol. 2017;47:458-469 pubmed publisher
Iwata H, Goettsch C, Sharma A, Ricchiuto P, Goh W, Halu A, et al. PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation. Nat Commun. 2016;7:12849 pubmed publisher
Klotz L, Kuzmanov I, Hucke S, Gross C, Posevitz V, Dreykluft A, et al. B7-H1 shapes T-cell-mediated brain endothelial cell dysfunction and regional encephalitogenicity in spontaneous CNS autoimmunity. Proc Natl Acad Sci U S A. 2016;113:E6182-E6191 pubmed
Yeh M, Shih Y, Chung H, Chou J, Lu H, Liu C, et al. Chitosan promotes immune responses, ameliorates glutamic oxaloacetic transaminase and glutamic pyruvic transaminase, but enhances lactate dehydrogenase levels in normal mice in vivo. Exp Ther Med. 2016;11:1300-1306 pubmed
Akahori H, Karmali V, Polavarapu R, Lyle A, Weiss D, Shin E, et al. CD163 interacts with TWEAK to regulate tissue regeneration after ischaemic injury. Nat Commun. 2015;6:7792 pubmed publisher
Kusters D, Chatrou M, Willems B, de Saint Hubert M, Bauwens M, van der Vorst E, et al. Pharmacological Treatment with Annexin A1 Reduces Atherosclerotic Plaque Burden in LDLR-/- Mice on Western Type Diet. PLoS ONE. 2015;10:e0130484 pubmed publisher
Khan I, Perrard X, Brunner G, Lui H, Sparks L, Smith S, et al. Intermuscular and perimuscular fat expansion in obesity correlates with skeletal muscle T cell and macrophage infiltration and insulin resistance. Int J Obes (Lond). 2015;39:1607-18 pubmed publisher
Tsuneki M, Hardee S, Michaud M, Morotti R, Lavik E, Madri J. A hydrogel-endothelial cell implant mimics infantile hemangioma: modulation by survivin and the Hippo pathway. Lab Invest. 2015;95:765-80 pubmed publisher
Yan H, Zhao L, Wu X, Liu H, Wu C, Li Y, et al. Inflammation and pathological damage to the lungs of mice are only partially reversed following smoking cessation on subacute exposure to cigarette smoke. Mol Med Rep. 2015;11:4246-54 pubmed publisher
Aschar Sobbi R, Izaddoustdar F, Korogyi A, Wang Q, Farman G, Yang F, et al. Increased atrial arrhythmia susceptibility induced by intense endurance exercise in mice requires TNFα. Nat Commun. 2015;6:6018 pubmed publisher
Chueh F, Lin J, Lin J, Weng S, Huang Y, Chung J. Crude extract of Polygonum cuspidatum stimulates immune responses in normal mice by increasing the percentage of Mac-3-positive cells and enhancing macrophage phagocytic activity and natural killer cell cytotoxicity. Mol Med Rep. 2015;11:127-32 pubmed publisher
Meisner J, Song J, Price R. Arteriolar and venular remodeling are differentially regulated by bone marrow-derived cell-specific CX3CR1 and CCR2 expression. PLoS ONE. 2012;7:e46312 pubmed publisher
Watt V, Chamberlain J, Steiner T, Francis S, Crossman D. TRAIL attenuates the development of atherosclerosis in apolipoprotein E deficient mice. Atherosclerosis. 2011;215:348-54 pubmed publisher
Aharonowiz M, Einstein O, Fainstein N, Lassmann H, Reubinoff B, Ben Hur T. Neuroprotective effect of transplanted human embryonic stem cell-derived neural precursors in an animal model of multiple sclerosis. PLoS ONE. 2008;3:e3145 pubmed publisher
Nahrendorf M, Swirski F, Aikawa E, Stangenberg L, Wurdinger T, Figueiredo J, et al. The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions. J Exp Med. 2007;204:3037-47 pubmed
Agrawal S, Anderson P, Durbeej M, Van Rooijen N, Ivars F, Opdenakker G, et al. Dystroglycan is selectively cleaved at the parenchymal basement membrane at sites of leukocyte extravasation in experimental autoimmune encephalomyelitis. J Exp Med. 2006;203:1007-19 pubmed
Walter M, Kajiwara N, Karanja P, Castro M, Holtzman M. Interleukin 12 p40 production by barrier epithelial cells during airway inflammation. J Exp Med. 2001;193:339-51 pubmed
product information
Cat.# :
553322
Brand :
BD Pharmingen
Name :
Mac-3
Format :
Purified
Clone :
M3/84
Isotype :
Rat IgG 1
React :
Ms
Conc :
0.5 mg/ml
Apps :
FCM , IHC(F)* , IHC(Fr
Size :
0.5 mg
Status :
RUO
more info or order :
company information