product summary
company name :
BD Biosciences
other brands :
Transduction Laboratories, PharMingen, Difco
product type :
antibody
product name :
CD25
catalog :
553068
quantity :
0.5 mg
price :
220.00 USD
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
7D4
reactivity :
human, mouse
application :
immunohistochemistry, flow cytometry, chromatin immunoprecipitation
more info or order :
citations: 44
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; 1:500; loading ...; fig 1h
Chorro L, Suzuki M, Chin S, Williams T, Snapp E, Odagiu L, et al. Interleukin 2 modulates thymic-derived regulatory T cell epigenetic landscape. Nat Commun. 2018;9:5368 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s5a
Morita K, Okamura T, Inoue M, Komai T, Teruya S, Iwasaki Y, et al. Egr2 and Egr3 in regulatory T cells cooperatively control systemic autoimmunity through Ltbp3-mediated TGF-β3 production. Proc Natl Acad Sci U S A. 2016;113:E8131-E8140 pubmed
  • flow cytometry; mouse; loading ...; fig 4b
Park K, Mikulski Z, Seo G, Andreyev A, Marcovecchio P, Blatchley A, et al. The transcription factor NR4A3 controls CD103+ dendritic cell migration. J Clin Invest. 2016;126:4603-4615 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1a
Vogel K, Bell L, Galloway A, Ahlfors H, Turner M. The RNA-Binding Proteins Zfp36l1 and Zfp36l2 Enforce the Thymic ?-Selection Checkpoint by Limiting DNA Damage Response Signaling and Cell Cycle Progression. J Immunol. 2016;197:2673-2685 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1e
Carow B, Gao Y, Coquet J, Reilly M, Rottenberg M. lck-Driven Cre Expression Alters T Cell Development in the Thymus and the Frequencies and Functions of Peripheral T Cell Subsets. J Immunol. 2016;197:2261-8 pubmed publisher
  • flow cytometry; mouse; fig s2
Drake L, Iijima K, Bartemes K, Kita H. Group 2 Innate Lymphoid Cells Promote an Early Antibody Response to a Respiratory Antigen in Mice. J Immunol. 2016;197:1335-42 pubmed publisher
  • flow cytometry; human; loading ...; fig 1d
Goldstein J, Burlion A, Zaragoza B, Sendeyo K, Polansky J, Huehn J, et al. Inhibition of the JAK/STAT Signaling Pathway in Regulatory T Cells Reveals a Very Dynamic Regulation of Foxp3 Expression. PLoS ONE. 2016;11:e0153682 pubmed publisher
  • flow cytometry; mouse; fig 4
Fend L, Remy Ziller C, Foloppe J, Kempf J, Cochin S, Barraud L, et al. Oncolytic virotherapy with an armed vaccinia virus in an orthotopic model of renal carcinoma is associated with modification of the tumor microenvironment. Oncoimmunology. 2016;5:e1080414 pubmed
  • flow cytometry; mouse; fig s3a
Xiong Y, Ahmad S, Iwami D, Brinkman C, Bromberg J. T-bet Regulates Natural Regulatory T Cell Afferent Lymphatic Migration and Suppressive Function. J Immunol. 2016;196:2526-40 pubmed publisher
  • immunohistochemistry; human; 1:25; fig 4
Freeman B, Ogle B. Viral-mediated fusion of mesenchymal stem cells with cells of the infarcted heart hinders healing via decreased vascularization and immune modulation. Sci Rep. 2016;6:20283 pubmed publisher
  • flow cytometry; mouse; fig 4
Vivar O, Masi G, Carpier J, Magalhaes J, Galgano D, Pazour G, et al. IFT20 controls LAT recruitment to the immune synapse and T-cell activation in vivo. Proc Natl Acad Sci U S A. 2016;113:386-91 pubmed publisher
  • flow cytometry; mouse; fig s1
Smith K, Filbey K, Reynolds L, Hewitson J, Harcus Y, Boon L, et al. Low-level regulatory T-cell activity is essential for functional type-2 effector immunity to expel gastrointestinal helminths. Mucosal Immunol. 2016;9:428-43 pubmed publisher
  • flow cytometry; mouse; 1:100; fig s4
Castiglioni A, Corna G, Rigamonti E, Basso V, Vezzoli M, Monno A, et al. FOXP3+ T Cells Recruited to Sites of Sterile Skeletal Muscle Injury Regulate the Fate of Satellite Cells and Guide Effective Tissue Regeneration. PLoS ONE. 2015;10:e0128094 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1a
Becker P, Hervouet C, Mason G, KWON S, Klavinskis L. Skin vaccination with live virus vectored microneedle arrays induce long lived CD8(+) T cell memory. Vaccine. 2015;33:4691-8 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 4
Bouchery T, Kyle R, Camberis M, Shepherd A, Filbey K, Smith A, et al. ILC2s and T cells cooperate to ensure maintenance of M2 macrophages for lung immunity against hookworms. Nat Commun. 2015;6:6970 pubmed publisher
  • flow cytometry; mouse
Baeyens A, Saadoun D, Billiard F, Rouers A, Grégoire S, Zaragoza B, et al. Effector T cells boost regulatory T cell expansion by IL-2, TNF, OX40, and plasmacytoid dendritic cells depending on the immune context. J Immunol. 2015;194:999-1010 pubmed publisher
  • flow cytometry; mouse
Mouchacca P, Chasson L, Frick M, Foray C, Schmitt Verhulst A, Boyer C. Visualization of granzyme B-expressing CD8 T cells during primary and secondary immune responses to Listeria monocytogenes. Immunology. 2015;145:24-33 pubmed publisher
  • flow cytometry; mouse
Qiao G, Zhao Y, Li Z, Tang P, Langdon W, Yang T, et al. T cell activation threshold regulated by E3 ubiquitin ligase Cbl-b determines fate of inducible regulatory T cells. J Immunol. 2013;191:632-9 pubmed publisher
  • chromatin immunoprecipitation; mouse
Stone J, McMillan R, Skaar D, Bradshaw J, Jirtle R, Sikes M. DNA double-strand breaks relieve USF-mediated repression of D?2 germline transcription in developing thymocytes. J Immunol. 2012;188:2266-75 pubmed publisher
Evans A, Moser J, Krug L, Pozharskaya V, Mora A, Speck S. A gammaherpesvirus-secreted activator of Vbeta4+ CD8+ T cells regulates chronic infection and immunopathology. J Exp Med. 2008;205:669-84 pubmed publisher
Coombes J, Siddiqui K, Arancibia Cárcamo C, Hall J, Sun C, Belkaid Y, et al. A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism. J Exp Med. 2007;204:1757-64 pubmed
Bopp T, Becker C, Klein M, Klein Hessling S, Palmetshofer A, Serfling E, et al. Cyclic adenosine monophosphate is a key component of regulatory T cell-mediated suppression. J Exp Med. 2007;204:1303-10 pubmed
Jankovic D, Kullberg M, Feng C, Goldszmid R, Collazo C, Wilson M, et al. Conventional T-bet(+)Foxp3(-) Th1 cells are the major source of host-protective regulatory IL-10 during intracellular protozoan infection. J Exp Med. 2007;204:273-83 pubmed
Tarbell K, Petit L, Zuo X, Toy P, Luo X, Mqadmi A, et al. Dendritic cell-expanded, islet-specific CD4+ CD25+ CD62L+ regulatory T cells restore normoglycemia in diabetic NOD mice. J Exp Med. 2007;204:191-201 pubmed
Jiang H, Pan F, Erickson L, Jang M, Sanui T, Kunisaki Y, et al. Deletion of DOCK2, a regulator of the actin cytoskeleton in lymphocytes, suppresses cardiac allograft rejection. J Exp Med. 2005;202:1121-30 pubmed
Ko K, Yamazaki S, Nakamura K, Nishioka T, Hirota K, Yamaguchi T, et al. Treatment of advanced tumors with agonistic anti-GITR mAb and its effects on tumor-infiltrating Foxp3+CD25+CD4+ regulatory T cells. J Exp Med. 2005;202:885-91 pubmed
Fahlén L, Read S, Gorelik L, Hurst S, Coffman R, Flavell R, et al. T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells. J Exp Med. 2005;201:737-46 pubmed
Bopp T, Palmetshofer A, Serfling E, Heib V, Schmitt S, Richter C, et al. NFATc2 and NFATc3 transcription factors play a crucial role in suppression of CD4+ T lymphocytes by CD4+ CD25+ regulatory T cells. J Exp Med. 2005;201:181-7 pubmed
Tarbell K, Yamazaki S, Olson K, Toy P, Steinman R. CD25+ CD4+ T cells, expanded with dendritic cells presenting a single autoantigenic peptide, suppress autoimmune diabetes. J Exp Med. 2004;199:1467-77 pubmed
Avichezer D, Grajewski R, Chan C, Mattapallil M, Silver P, Raber J, et al. An immunologically privileged retinal antigen elicits tolerance: major role for central selection mechanisms. J Exp Med. 2003;198:1665-76 pubmed
Fujikawa K, Miletic A, Alt F, Faccio R, Brown T, Hoog J, et al. Vav1/2/3-null mice define an essential role for Vav family proteins in lymphocyte development and activation but a differential requirement in MAPK signaling in T and B cells. J Exp Med. 2003;198:1595-608 pubmed
Karsunky H, Merad M, Cozzio A, Weissman I, Manz M. Flt3 ligand regulates dendritic cell development from Flt3+ lymphoid and myeloid-committed progenitors to Flt3+ dendritic cells in vivo. J Exp Med. 2003;198:305-13 pubmed
Oldenhove G, de Heusch M, Urbain Vansanten G, Urbain J, Maliszewski C, Leo O, et al. CD4+ CD25+ regulatory T cells control T helper cell type 1 responses to foreign antigens induced by mature dendritic cells in vivo. J Exp Med. 2003;198:259-66 pubmed
Löhning M, Hutloff A, Kallinich T, Mages H, Bonhagen K, Radbruch A, et al. Expression of ICOS in vivo defines CD4+ effector T cells with high inflammatory potential and a strong bias for secretion of interleukin 10. J Exp Med. 2003;197:181-93 pubmed
Cohen J, Trenado A, Vasey D, Klatzmann D, Salomon B. CD4(+)CD25(+) immunoregulatory T Cells: new therapeutics for graft-versus-host disease. J Exp Med. 2002;196:401-6 pubmed
Shi X, Xie C, Kreska D, Richardson J, Mohan C. Genetic dissection of SLE: SLE1 and FAS impact alternate pathways leading to lymphoproliferative autoimmunity. J Exp Med. 2002;196:281-92 pubmed
Piccirillo C, Letterio J, Thornton A, McHugh R, Mamura M, Mizuhara H, et al. CD4(+)CD25(+) regulatory T cells can mediate suppressor function in the absence of transforming growth factor beta1 production and responsiveness. J Exp Med. 2002;196:237-46 pubmed
Magnan A, Di Bartolo V, Mura A, Boyer C, Richelme M, Lin Y, et al. T cell development and T cell responses in mice with mutations affecting tyrosines 292 or 315 of the ZAP-70 protein tyrosine kinase. J Exp Med. 2001;194:491-505 pubmed
Bensinger S, Bandeira A, Jordan M, Caton A, Laufer T. Major histocompatibility complex class II-positive cortical epithelium mediates the selection of CD4(+)25(+) immunoregulatory T cells. J Exp Med. 2001;194:427-38 pubmed
Fehniger T, Suzuki K, Ponnappan A, VanDeusen J, Cooper M, Florea S, et al. Fatal leukemia in interleukin 15 transgenic mice follows early expansions in natural killer and memory phenotype CD8+ T cells. J Exp Med. 2001;193:219-31 pubmed
Takahashi T, Tagami T, Yamazaki S, Uede T, Shimizu J, Sakaguchi N, et al. Immunologic self-tolerance maintained by CD25(+)CD4(+) regulatory T cells constitutively expressing cytotoxic T lymphocyte-associated antigen 4. J Exp Med. 2000;192:303-10 pubmed
Read S, Malmstrom V, Powrie F. Cytotoxic T lymphocyte-associated antigen 4 plays an essential role in the function of CD25(+)CD4(+) regulatory cells that control intestinal inflammation. J Exp Med. 2000;192:295-302 pubmed
Costello P, Cleverley S, Galandrini R, Henning S, Cantrell D. The GTPase rho controls a p53-dependent survival checkpoint during thymopoiesis. J Exp Med. 2000;192:77-85 pubmed
Maki K, Nagata K, Kitamura F, Takemori T, Karasuyama H. Immunoglobulin beta signaling regulates locus accessibility for ordered immunoglobulin gene rearrangements. J Exp Med. 2000;191:1333-40 pubmed
product information
Cat.# :
553068
Brand :
BD Pharmingen
Name :
CD25
Format :
Purified
Clone :
7D4
Isotype :
Rat IgM
React :
Ms
Conc :
0.5 mg/ml
Apps :
FCM
Size :
0.5 mg
Status :
RUO
List Price :
220.00 USD
more info or order :
company information