product summary
company name :
BD Biosciences
other brands :
Transduction Laboratories, PharMingen, Difco
product type :
antibody
product name :
MLH-1
catalog :
550838
quantity :
1 mL
price :
172.00 USD
clonality :
monoclonal
host :
mouse
conjugate :
nonconjugated
clone name :
G168-15
reactivity :
African green monkey, human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section
more info or order :
citations: 31
Published Application/Species/Sample/DilutionReference
  • immunocytochemistry; mouse; loading ...; fig 3f
Huang G, Liu L, Wang H, Gou M, Gong P, Tian C, et al. Tet1 Deficiency Leads to Premature Reproductive Aging by Reducing Spermatogonia Stem Cells and Germ Cell Differentiation. iScience. 2020;23:100908 pubmed publisher
  • immunohistochemistry; mouse; 1:50; loading ...; fig s6d
Liu H, Huang T, Li M, Li M, Zhang C, Jiang J, et al. SCRE serves as a unique synaptonemal complex fastener and is essential for progression of meiosis prophase I in mice. Nucleic Acids Res. 2019;47:5670-5683 pubmed publisher
  • immunocytochemistry; African green monkey; 1:200; loading ...; fig 4
Dembowski J, Dremel S, DeLuca N. Replication-Coupled Recruitment of Viral and Cellular Factors to Herpes Simplex Virus Type 1 Replication Forks for the Maintenance and Expression of Viral Genomes. PLoS Pathog. 2017;13:e1006166 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:10; loading ...; fig 1
Huang C, Huang S, Chien C, Lee H, Yang S, Chang C, et al. Impact of microsatellite status on chemotherapy for colorectal cancer patients with KRAS or BRAF mutation. Oncol Lett. 2016;12:4427-4434 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:50; loading ...; tbl 1
Takahashi S, Kohashi K, Yamamoto H, Hirahashi M, Kumagai R, Takizawa N, et al. Expression of adhesion molecules and epithelial-mesenchymal transition factors in medullary carcinoma of the colorectum. Hum Pathol. 2015;46:1257-66 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:50; loading ...; fig 4
Yang F, Silber S, Leu N, Oates R, Marszalek J, Skaletsky H, et al. TEX11 is mutated in infertile men with azoospermia and regulates genome-wide recombination rates in mouse. EMBO Mol Med. 2015;7:1198-210 pubmed publisher
  • immunohistochemistry; human; 1:50
Geels Y, van der Putten L, van Tilborg A, Lurkin I, Zwarthoff E, Pijnenborg J, et al. Immunohistochemical and genetic profiles of endometrioid endometrial carcinoma arising from atrophic endometrium. Gynecol Oncol. 2015;137:245-51 pubmed publisher
  • immunohistochemistry; human; 1:25; loading ...
Boulagnon C, Dudez O, Beaudoux O, Dalstein V, Kianmanesh R, Bouché O, et al. BRAFV600E Gene Mutation in Colonic Adenocarcinomas. Immunohistochemical Detection Using Tissue Microarray and Clinicopathologic Characteristics: An 86 Case Series. Appl Immunohistochem Mol Morphol. 2016;24:88-96 pubmed publisher
  • immunohistochemistry - paraffin section; human
Vilar E, Mork M, Cuddy A, Borràs E, Bannon S, Taggart M, et al. Role of microsatellite instability-low as a diagnostic biomarker of Lynch syndrome in colorectal cancer. Cancer Genet. 2014;207:495-502 pubmed publisher
  • western blot; human
Lin B, Gupta D, Heinen C. Human pluripotent stem cells have a novel mismatch repair-dependent damage response. J Biol Chem. 2014;289:24314-24 pubmed publisher
  • immunohistochemistry - paraffin section; human; 1:100
Koppensteiner R, Samartzis E, Noske A, von Teichman A, Dedes I, Gwerder M, et al. Effect of MRE11 loss on PARP-inhibitor sensitivity in endometrial cancer in vitro. PLoS ONE. 2014;9:e100041 pubmed publisher
  • immunohistochemistry; human
Malesci A, Basso G, Bianchi P, Fini L, Grizzi F, Celesti G, et al. Molecular heterogeneity and prognostic implications of synchronous advanced colorectal neoplasia. Br J Cancer. 2014;110:1228-35 pubmed publisher
  • immunohistochemistry - paraffin section; human; fig 2
Boulagnon C, Jazeron J, Diaz Cives A, Ehrhard F, Bouche O, Diebold M. Filiform polyposis: A benign entity? Case report and literature review. Pathol Res Pract. 2014;210:189-93 pubmed publisher
  • immunocytochemistry; mouse; 1:50
Takada Y, Isono K, Shinga J, Turner J, Kitamura H, Ohara O, et al. Mammalian Polycomb Scmh1 mediates exclusion of Polycomb complexes from the XY body in the pachytene spermatocytes. Development. 2007;134:579-90 pubmed
Sakai K, Ito C, Wakabayashi M, Kanzaki S, Ito T, Takada S, et al. Usp26 mutation in mice leads to defective spermatogenesis depending on genetic background. Sci Rep. 2019;9:13757 pubmed publisher
Goeppert B, Roessler S, Renner M, Loeffler M, Singer S, Rausch M, et al. Low frequency of mismatch repair deficiency in gallbladder cancer. Diagn Pathol. 2019;14:36 pubmed publisher
Goeppert B, Roessler S, Renner M, Singer S, Mehrabi A, Vogel M, et al. Mismatch repair deficiency is a rare but putative therapeutically relevant finding in non-liver fluke associated cholangiocarcinoma. Br J Cancer. 2019;120:109-114 pubmed publisher
Lin Z, Liu J, Peng L, Zhang D, Jin M, Wang J, et al. Complete pathological response following neoadjuvant FOLFOX chemotherapy in BRCA2-mutant locally advanced rectal cancer: a case report. BMC Cancer. 2018;18:1253 pubmed publisher
Tian H, Billings T, Petkov P. CXXC1 is not essential for normal DNA double-strand break formation and meiotic recombination in mouse. PLoS Genet. 2018;14:e1007657 pubmed publisher
Zhou Z, Wang L, Ge F, Gong P, Wang H, Wang F, et al. Pold3 is required for genomic stability and telomere integrity in embryonic stem cells and meiosis. Nucleic Acids Res. 2018;46:3468-3486 pubmed publisher
Kuzniar A, Laffeber C, Eppink B, Bezstarosti K, Dekkers D, Woelders H, et al. Semi-quantitative proteomics of mammalian cells upon short-term exposure to non-ionizing electromagnetic fields. PLoS ONE. 2017;12:e0170762 pubmed publisher
Valtcheva N, Lang F, Noske A, Samartzis E, Schmidt A, Bellini E, et al. Tracking the origin of simultaneous endometrial and ovarian cancer by next-generation sequencing - a case report. BMC Cancer. 2017;17:66 pubmed publisher
Brandt S, Samartzis E, Zimmermann A, Fink D, Moch H, Noske A, et al. Lack of MRE11-RAD50-NBS1 (MRN) complex detection occurs frequently in low-grade epithelial ovarian cancer. BMC Cancer. 2017;17:44 pubmed publisher
Qiao H, Prasada Rao H, Yang Y, Fong J, Cloutier J, Deacon D, et al. Antagonistic roles of ubiquitin ligase HEI10 and SUMO ligase RNF212 regulate meiotic recombination. Nat Genet. 2014;46:194-9 pubmed publisher
Luo M, Yang F, Leu N, Landaiche J, Handel M, Benavente R, et al. MEIOB exhibits single-stranded DNA-binding and exonuclease activities and is essential for meiotic recombination. Nat Commun. 2013;4:2788 pubmed publisher
van Grieken N, Aoyama T, Aoyma T, Chambers P, Bottomley D, Ward L, et al. KRAS and BRAF mutations are rare and related to DNA mismatch repair deficiency in gastric cancer from the East and the West: results from a large international multicentre study. Br J Cancer. 2013;108:1495-501 pubmed publisher
Beggs A, Domingo E, Abulafi M, Hodgson S, Tomlinson I. A study of genomic instability in early preneoplastic colonic lesions. Oncogene. 2013;32:5333-7 pubmed publisher
Levidou G, Saetta A, Gigelou F, Karlou M, Papanastasiou P, Stamatelli A, et al. ERK/pERK expression and B-raf mutations in colon adenocarcinomas: correlation with clinicopathological characteristics. World J Surg Oncol. 2012;10:47 pubmed publisher
Jensen S, Vainer B, Kruhøffer M, Sørensen J. Microsatellite instability in colorectal cancer and association with thymidylate synthase and dihydropyrimidine dehydrogenase expression. BMC Cancer. 2009;9:25 pubmed publisher
Kolas N, Svetlanov A, Lenzi M, Macaluso F, Lipkin S, Liskay R, et al. Localization of MMR proteins on meiotic chromosomes in mice indicates distinct functions during prophase I. J Cell Biol. 2005;171:447-58 pubmed
Sasiadek M, Stembalska Kozlowska A, Smigiel R, Ramsey D, Kayademir T, Blin N. Impairment of MLH1 and CDKN2A in oncogenesis of laryngeal cancer. Br J Cancer. 2004;90:1594-9 pubmed
product information
Cat.# :
550838
Brand :
BD Pharmingen
Name :
MLH-1
Format :
Purified
Clone :
G168-15
Isotype :
Ms IgG 1
React :
Hu
Conc :
250 µg/ml
Apps :
IHC(F)* , IHC(Fr) , WB
Size :
1 mL
Status :
RUO
List Price :
172.00 USD
more info or order :
company information