product summary
company name :
BD Biosciences
other brands :
Transduction Laboratories, PharMingen, Difco
product type :
antibody
product name :
CD8a
catalog :
550281
quantity :
1 mL
clonality :
monoclonal
host :
rat
conjugate :
nonconjugated
clone name :
53-6.7
reactivity :
human, mouse
application :
western blot, immunohistochemistry, immunocytochemistry, flow cytometry, immunohistochemistry - paraffin section, immunohistochemistry - frozen section, blocking or activating experiments, other
more info or order :
citations: 267
Published Application/Species/Sample/DilutionReference
  • flow cytometry; mouse; fig 3a
Zhu Y, Elsheikha H, Wang J, Fang S, He J, Zhu X, et al. Synergy between Toxoplasma gondii type I ΔGRA17 immunotherapy and PD-L1 checkpoint inhibition triggers the regression of targeted and distal tumors. J Immunother Cancer. 2021;9: pubmed publisher
  • flow cytometry; human; loading ...; fig s2b
Fahy N, Palomares Cabeza V, Lolli A, Witte Bouma J, Merino A, Ridwan Y, et al. Chondrogenically Primed Human Mesenchymal Stem Cells Persist and Undergo Early Stages of Endochondral Ossification in an Immunocompetent Xenogeneic Model. Front Immunol. 2021;12:715267 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 4b, 6a
Droho S, Cuda C, Perlman H, Lavine J. Macrophage-derived interleukin-6 is necessary and sufficient for choroidal angiogenesis. Sci Rep. 2021;11:18084 pubmed publisher
  • flow cytometry; mouse; 1:300; loading ...; fig s2b
Moreira T, Mangani D, Cox L, Leibowitz J, Lobo E, Oliveira M, et al. PD-L1+ and XCR1+ dendritic cells are region-specific regulators of gut homeostasis. Nat Commun. 2021;12:4907 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s13
Mai J, Li Z, Xia X, Zhang J, Li J, Liu H, et al. Synergistic Activation of Antitumor Immunity by a Particulate Therapeutic Vaccine. Adv Sci (Weinh). 2021;8:2100166 pubmed publisher
  • flow cytometry; mouse; fig 2c
Bohannon C, Ende Z, Cao W, Mboko W, Ranjan P, Kumar A, et al. Influenza Virus Infects and Depletes Activated Adaptive Immune Responders. Adv Sci (Weinh). 2021;8:e2100693 pubmed publisher
  • flow cytometry; mouse; 1:100; loading ...; fig s3b
Kemp S, Carpenter E, Steele N, Donahue K, Nwosu Z, Pacheco A, et al. Apolipoprotein E Promotes Immune Suppression in Pancreatic Cancer through NF-κB-Mediated Production of CXCL1. Cancer Res. 2021;81:4305-4318 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1b
Kerselidou D, Dohai B, Nelson D, Daakour S, De Cock N, Hassoun Z, et al. Alternative glycosylation controls endoplasmic reticulum dynamics and tubular extension in mammalian cells. Sci Adv. 2021;7: pubmed publisher
  • flow cytometry; mouse; loading ...; fig 4e
Kalinina A, Khromykh L, Kazansky D, Deykin A, Silaeva Y. Suppression of the Immune Response by Syngeneic Splenocytes Adoptively Transferred to Sublethally Irradiated Mice. Acta Naturae. 2021;13:116-126 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 2g
Liu Y, Li Y, Loh Y, Singer J, Zhu W, Macia L, et al. Fiber Derived Microbial Metabolites Prevent Acute Kidney Injury Through G-Protein Coupled Receptors and HDAC Inhibition. Front Cell Dev Biol. 2021;9:648639 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3b
Yang C, Kwon D, Kim M, Im S, Lee Y. Commensal Microbiome Expands Tγδ17 Cells in the Lung and Promotes Particulate Matter-Induced Acute Neutrophilia. Front Immunol. 2021;12:645741 pubmed publisher
  • flow cytometry; mouse; 1:200; loading ...
Borges P, Waclawiak I, Georgii J, Fraga Junior V, Barros J, Lemos F, et al. Adenosine Diphosphate Improves Wound Healing in Diabetic Mice Through P2Y12 Receptor Activation. Front Immunol. 2021;12:651740 pubmed publisher
  • immunohistochemistry - frozen section; mouse; loading ...; fig s3a
Brea R, Valdecantos P, Rada P, Alen R, García Monzón C, Bosca L, et al. Chronic treatment with acetaminophen protects against liver aging by targeting inflammation and oxidative stress. Aging (Albany NY). 2021;13:7800-7827 pubmed publisher
  • flow cytometry; mouse; loading ...
Tyagi A, Darby T, Hsu E, Yu M, Pal S, Dar H, et al. The gut microbiota is a transmissible determinant of skeletal maturation. elife. 2021;10: pubmed publisher
  • flow cytometry; mouse; 1:500; fig 1j
Castiello M, Bosticardo M, Sacchetti N, Calzoni E, Fontana E, Yamazaki Y, et al. Efficacy and safety of anti-CD45-saporin as conditioning agent for RAG deficiency. J Allergy Clin Immunol. 2021;147:309-320.e6 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 8a
Grand M, Waqasi M, Demarta Gatsi C, Wei Y, Peronet R, Commere P, et al. Hepatic Inflammation Confers Protective Immunity Against Liver Stages of Malaria Parasite. Front Immunol. 2020;11:585502 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 5d
Myers D, Abram C, Wildes D, Belwafa A, Welsh A, Schulze C, et al. Shp1 Loss Enhances Macrophage Effector Function and Promotes Anti-Tumor Immunity. Front Immunol. 2020;11:576310 pubmed publisher
  • flow cytometry; mouse; 1:200; loading ...; fig 1f
Rundqvist H, Veliça P, Barbieri L, Gameiro P, Bargiela D, Gojkovic M, et al. Cytotoxic T-cells mediate exercise-induced reductions in tumor growth. elife. 2020;9: pubmed publisher
  • flow cytometry; mouse; 1:200; loading ...; fig s6-1b
Ricci B, Tycksen E, Celik H, Belle J, Fontana F, Civitelli R, et al. Osterix-Cre marks distinct subsets of CD45- and CD45+ stromal populations in extra-skeletal tumors with pro-tumorigenic characteristics. elife. 2020;9: pubmed publisher
  • flow cytometry; mouse; loading ...; fig 4d
Luoni M, Giannelli S, Indrigo M, Niro A, Massimino L, Iannielli A, et al. Whole brain delivery of an instability-prone Mecp2 transgene improves behavioral and molecular pathological defects in mouse models of Rett syndrome. elife. 2020;9: pubmed publisher
  • flow cytometry; mouse; 1:200; loading ...; fig 4h
Stebegg M, Bignon A, Hill D, Silva Cayetano A, Krueger C, Vanderleyden I, et al. Rejuvenating conventional dendritic cells and T follicular helper cell formation after vaccination. elife. 2020;9: pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1m
Choi S, Bae H, Jeong S, Park I, Cho H, Hong S, et al. YAP/TAZ direct commitment and maturation of lymph node fibroblastic reticular cells. Nat Commun. 2020;11:519 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 6c
Canel M, Taggart D, Sims A, Lonergan D, Waizenegger I, Serrels A. T-cell co-stimulation in combination with targeting FAK drives enhanced anti-tumor immunity. elife. 2020;9: pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1.25 ug/ml; loading ...; fig 4a
Enríquez Pérez J, Kopecky J, Visse E, Darabi A, Siesjo P. Convection-enhanced delivery of temozolomide and whole cell tumor immunizations in GL261 and KR158 experimental mouse gliomas. BMC Cancer. 2020;20:7 pubmed publisher
  • flow cytometry; mouse; fig 2e
Williford J, Ishihara J, Ishihara A, Mansurov A, Hosseinchi P, Marchell T, et al. Recruitment of CD103+ dendritic cells via tumor-targeted chemokine delivery enhances efficacy of checkpoint inhibitor immunotherapy. Sci Adv. 2019;5:eaay1357 pubmed publisher
  • flow cytometry; mouse; 1:200; loading ...; fig s4a
Li A, Herbst R, Canner D, Schenkel J, Smith O, Kim J, et al. IL-33 Signaling Alters Regulatory T Cell Diversity in Support of Tumor Development. Cell Rep. 2019;29:2998-3008.e8 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2a
Zhao Y, Yang Q, Jin C, Feng Y, Xie S, Xie H, et al. Changes of CD103-expressing pulmonary CD4+ and CD8+ T cells in S. japonicum infected C57BL/6 mice. BMC Infect Dis. 2019;19:999 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s3a
Chu C, Murdock M, Jing D, Won T, Chung H, Kressel A, et al. The microbiota regulate neuronal function and fear extinction learning. Nature. 2019;574:543-548 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3b, 4b
Lecocq Q, Zeven K, De Vlaeminck Y, Martens S, Massa S, Goyvaerts C, et al. Noninvasive Imaging of the Immune Checkpoint LAG-3 Using Nanobodies, from Development to Pre-Clinical Use. Biomolecules. 2019;9: pubmed publisher
  • flow cytometry; mouse; loading ...
Veglia F, Tyurin V, Blasi M, De Leo A, Kossenkov A, Donthireddy L, et al. Fatty acid transport protein 2 reprograms neutrophils in cancer. Nature. 2019;569:73-78 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3d
Yamamoto T, Lee P, Vodnala S, Gurusamy D, Kishton R, Yu Z, et al. T cells genetically engineered to overcome death signaling enhance adoptive cancer immunotherapy. J Clin Invest. 2019;129:1551-1565 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 4a
Silva D, Yu S, Ulge U, Spangler J, Jude K, Labao Almeida C, et al. De novo design of potent and selective mimics of IL-2 and IL-15. Nature. 2019;565:186-191 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 4d
Lauron E, Yang L, Harvey I, Sojka D, Williams G, Paley M, et al. Viral MHCI inhibition evades tissue-resident memory T cell formation and responses. J Exp Med. 2019;216:117-132 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s3a
Dong S, Harrington B, Hu E, Greene J, Lehman A, Tran M, et al. PI3K p110δ inactivation antagonizes chronic lymphocytic leukemia and reverses T cell immune suppression. J Clin Invest. 2019;129:122-136 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s1a
Walsh S, Bastin D, Chen L, Nguyen A, Storbeck C, Lefebvre C, et al. Type I IFN blockade uncouples immunotherapy-induced antitumor immunity and autoimmune toxicity. J Clin Invest. 2019;129:518-530 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 5
Nicol M, Campbell G, Shaw D, Dransfield I, Ligertwood Y, Beard P, et al. Lack of IFNγ signaling attenuates spread of influenza A virus in vivo and leads to reduced pathogenesis. Virology. 2019;526:155-164 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s4a, s4b
Aydin E, Hallner A, Grauers Wiktorin H, Staffas A, Hellstrand K, Martner A. NOX2 inhibition reduces oxidative stress and prolongs survival in murine KRAS-induced myeloproliferative disease. Oncogene. 2019;38:1534-1543 pubmed publisher
  • flow cytometry; mouse; fig 1a
Qiao G, Bucsek M, Winder N, Chen M, Giridharan T, Olejniczak S, et al. β-Adrenergic signaling blocks murine CD8+ T-cell metabolic reprogramming during activation: a mechanism for immunosuppression by adrenergic stress. Cancer Immunol Immunother. 2019;68:11-22 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 4
Casagrande F, de Souza Ferreira S, Nunes F, Romera L, Dos Santos S, Tessaro F, et al. Insulin Modulates Paracoccidioides brasiliensis-Induced Inflammation by Restoring the Populations of NK Cells, Dendritic Cells, and B Lymphocytes in Lungs. J Diabetes Res. 2018;2018:6209694 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 5e
Meyer I, Goetzke C, Kespohl M, Sauter M, Heuser A, Eckstein V, et al. Silencing the CSF-1 Axis Using Nanoparticle Encapsulated siRNA Mitigates Viral and Autoimmune Myocarditis. Front Immunol. 2018;9:2303 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3b
Noh J, Kim Y, Kim D, Hwang J, Kim K, Choi D, et al. Small heterodimer partner negatively regulates C-X-C motif chemokine ligand 2 in hepatocytes during liver inflammation. Sci Rep. 2018;8:15222 pubmed publisher
  • flow cytometry; mouse; fig 2c
Amôr N, de Oliveira C, Gasparoto T, Vilas Boas V, Perri G, Kaneno R, et al. ST2/IL-33 signaling promotes malignant development of experimental squamous cell carcinoma by decreasing NK cells cytotoxicity and modulating the intratumoral cell infiltrate. Oncotarget. 2018;9:30894-30904 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 5b
White E, Gyulay G, Lhotak S, Szewczyk M, Chong T, Fuller M, et al. Sialidase down-regulation reduces non-HDL cholesterol, inhibits leukocyte transmigration, and attenuates atherosclerosis in ApoE knockout mice. J Biol Chem. 2018;293:14689-14706 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s17a
Vendetti F, Karukonda P, Clump D, Teo T, Lalonde R, Nugent K, et al. ATR kinase inhibitor AZD6738 potentiates CD8+ T cell-dependent antitumor activity following radiation. J Clin Invest. 2018;128:3926-3940 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3b
Feng Y, Liao Y, Huang W, Lai X, Luo J, Du C, et al. Mesenchymal stromal cells-derived matrix Gla protein contribute to the alleviation of experimental colitis. Cell Death Dis. 2018;9:691 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2a
Daenthanasanmak A, Wu Y, Iamsawat S, Nguyen H, Bastian D, Zhang M, et al. PIM-2 protein kinase negatively regulates T cell responses in transplantation and tumor immunity. J Clin Invest. 2018;128:2787-2801 pubmed publisher
  • immunohistochemistry; mouse; loading ...; fig 2d
Stefani F, Eberstål S, Vergani S, Kristiansen T, Bengzon J. Low-dose irradiated mesenchymal stromal cells break tumor defensive properties in vivo. Int J Cancer. 2018;143:2200-2212 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3e
Anker J, Naseem A, Mok H, Schaeffer A, Abdulkadir S, Thumbikat P. Multi-faceted immunomodulatory and tissue-tropic clinical bacterial isolate potentiates prostate cancer immunotherapy. Nat Commun. 2018;9:1591 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s4a
Metghalchi S, Vandestienne M, Haddad Y, Esposito B, Dairou J, Tedgui A, et al. Indoleamine 2 3-dioxygenase knockout limits angiotensin II-induced aneurysm in low density lipoprotein receptor-deficient mice fed with high fat diet. PLoS ONE. 2018;13:e0193737 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 4c
Khan A, Carpenter B, Santos e Sousa P, Pospori C, Khorshed R, Griffin J, et al. Redirection to the bone marrow improves T cell persistence and antitumor functions. J Clin Invest. 2018;128:2010-2024 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 9a
Kim I, Kim K, Lee E, Oh D, Park C, Park S, et al. Sox7 promotes high-grade glioma by increasing VEGFR2-mediated vascular abnormality. J Exp Med. 2018;215:963-983 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 5d
Seki A, Rutz S. Optimized RNP transfection for highly efficient CRISPR/Cas9-mediated gene knockout in primary T cells. J Exp Med. 2018;215:985-997 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 8d
Wheeler D, Sariol A, Meyerholz D, Perlman S. Microglia are required for protection against lethal coronavirus encephalitis in mice. J Clin Invest. 2018;128:931-943 pubmed publisher
  • flow cytometry; mouse; fig 1d
Kaufmann E, Sanz J, Dunn J, Khan N, Mendonça L, Pacis A, et al. BCG Educates Hematopoietic Stem Cells to Generate Protective Innate Immunity against Tuberculosis. Cell. 2018;172:176-190.e19 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3b, 4d
Garaycoechea J, Crossan G, Langevin F, Mulderrig L, Louzada S, Yang F, et al. Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells. Nature. 2018;553:171-177 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1c
Nakashima H, Alayo Q, Penaloza MacMaster P, Freeman G, Kuchroo V, Reardon D, et al. Modeling tumor immunity of mouse glioblastoma by exhausted CD8+ T cells. Sci Rep. 2018;8:208 pubmed publisher
  • flow cytometry; mouse; 1:200; loading ...; fig 2b
Guimarães G, Gomes M, Campos P, Marinho F, de Assis N, Silveira T, et al. Immunoproteasome Subunits Are Required for CD8+ T Cell Function and Host Resistance to Brucella abortus Infection in Mice. Infect Immun. 2018;86: pubmed publisher
  • flow cytometry; mouse; loading ...
Mailer R, Gisterå A, Polyzos K, Ketelhuth D, Hansson G. Hypercholesterolemia Enhances T Cell Receptor Signaling and Increases the Regulatory T Cell Population. Sci Rep. 2017;7:15655 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2b
Whitney P, Makhlouf C, MacLeod B, Ma J, Gressier E, Greyer M, et al. Effective Priming of Herpes Simplex Virus-Specific CD8+ T Cells In Vivo Does Not Require Infected Dendritic Cells. J Virol. 2018;92: pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3c
Capece T, Walling B, Lim K, Kim K, Bae S, Chung H, et al. A novel intracellular pool of LFA-1 is critical for asymmetric CD8+ T cell activation and differentiation. J Cell Biol. 2017;216:3817-3829 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 6a
Francis N, Every A, Ayodele B, Pike R, Mackie E, Pagel C. A T cell-specific knockout reveals an important role for protease-activated receptor 2 in lymphocyte development. Int J Biochem Cell Biol. 2017;92:95-103 pubmed publisher
  • flow cytometry; mouse; fig 4a
Sasaki F, Koga T, Saeki K, Okuno T, Kazuno S, Fujimura T, et al. Biochemical and immunological characterization of a novel monoclonal antibody against mouse leukotriene B4 receptor 1. PLoS ONE. 2017;12:e0185133 pubmed publisher
  • flow cytometry; mouse; fig s6b
Jung K, Heishi T, Incio J, Huang Y, Beech E, Pinter M, et al. Targeting CXCR4-dependent immunosuppressive Ly6Clow monocytes improves antiangiogenic therapy in colorectal cancer. Proc Natl Acad Sci U S A. 2017;114:10455-10460 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s1c
Sinclair C, Bommakanti G, Gardinassi L, Loebbermann J, Johnson M, Hakimpour P, et al. mTOR regulates metabolic adaptation of APCs in the lung and controls the outcome of allergic inflammation. Science. 2017;357:1014-1021 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2
Torcellan T, Hampton H, Bailey J, Tomura M, Brink R, Chtanova T. In vivo photolabeling of tumor-infiltrating cells reveals highly regulated egress of T-cell subsets from tumors. Proc Natl Acad Sci U S A. 2017;114:5677-5682 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s4c
Chowdhary V, Krogman A, Tilahun A, Alexander M, David C, Rajagopalan G. Concomitant Disruption of CD4 and CD8 Genes Facilitates the Development of Double Negative ?? TCR+ Peripheral T Cells That Respond Robustly to Staphylococcal Superantigen. J Immunol. 2017;198:4413-4424 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s1f
Claser C, de Souza J, Thorburn S, Grau G, Riley E, Renia L, et al. Host Resistance to Plasmodium-Induced Acute Immune Pathology Is Regulated by Interleukin-10 Receptor Signaling. Infect Immun. 2017;85: pubmed publisher
  • flow cytometry; mouse; fig 5c
Klein J, Moses K, Zelinskyy G, Sody S, Buer J, Lang S, et al. Combined toll-like receptor 3/7/9 deficiency on host cells results in T-cell-dependent control of tumour growth. Nat Commun. 2017;8:14600 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2b
Bhattacharyya M, Penaloza MacMaster P. T regulatory cells are critical for the maintenance, anamnestic expansion and protection elicited by vaccine-induced CD8 T cells. Immunology. 2017;151:340-348 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s2b
Ansa Addo E, Zhang Y, Yang Y, Hussey G, Howley B, Salem M, et al. Membrane-organizing protein moesin controls Treg differentiation and antitumor immunity via TGF-β signaling. J Clin Invest. 2017;127:1321-1337 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; loading ...; fig s3c
Ravindran D, Ridiandries A, Vanags L, Henriquez R, Cartland S, Tan J, et al. Chemokine binding protein 'M3' limits atherosclerosis in apolipoprotein E-/- mice. PLoS ONE. 2017;12:e0173224 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 6l
Knudson K, Pritzl C, Saxena V, Altman A, Daniels M, Teixeiro E. NFκB-Pim-1-Eomesodermin axis is critical for maintaining CD8 T-cell memory quality. Proc Natl Acad Sci U S A. 2017;114:E1659-E1667 pubmed publisher
  • immunohistochemistry - frozen section; mouse; 1:50
  • immunohistochemistry; mouse; loading ...; fig 48
Furukawa S, Nagaike M, Ozaki K. Databases for technical aspects of immunohistochemistry. J Toxicol Pathol. 2017;30:79-107 pubmed publisher
  • flow cytometry; mouse; fig 3
Ishiguro T, Fukawa T, Akaki K, Nagaoka K, Takeda T, Iwakura Y, et al. Absence of DCIR1 reduces the mortality rate of endotoxemic hepatitis in mice. Eur J Immunol. 2017;47:704-712 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s1c
Berghoff S, Gerndt N, Winchenbach J, Stumpf S, Hosang L, Odoardi F, et al. Dietary cholesterol promotes repair of demyelinated lesions in the adult brain. Nat Commun. 2017;8:14241 pubmed publisher
  • flow cytometry; human
Welsby I, Detienne S, N kuli F, Thomas S, Wouters S, Bechtold V, et al. Lysosome-Dependent Activation of Human Dendritic Cells by the Vaccine Adjuvant QS-21. Front Immunol. 2016;7:663 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s11
Yanagita T, Murata Y, Tanaka D, Motegi S, Arai E, Daniwijaya E, et al. Anti-SIRPα antibodies as a potential new tool for cancer immunotherapy. JCI Insight. 2017;2:e89140 pubmed publisher
  • flow cytometry; mouse; 1000 ng/ml; loading ...; fig 1a
Yamamura K, Uruno T, Shiraishi A, Tanaka Y, Ushijima M, Nakahara T, et al. The transcription factor EPAS1 links DOCK8 deficiency to atopic skin inflammation via IL-31 induction. Nat Commun. 2017;8:13946 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 5c
Rowe A, Yun H, Treat B, Kinchington P, Hendricks R. Subclinical Herpes Simplex Virus Type 1 Infections Provide Site-Specific Resistance to an Unrelated Pathogen. J Immunol. 2017;198:1706-1717 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s6a
van der Weyden L, Arends M, Campbell A, Bald T, Wardle Jones H, Griggs N, et al. Genome-wide in vivo screen identifies novel host regulators of metastatic colonization. Nature. 2017;541:233-236 pubmed publisher
  • flow cytometry; mouse; 1:200; loading ...; fig 4a
Larabee C, Desai S, Agasing A, Georgescu C, Wren J, Axtell R, et al. Loss of Nrf2 exacerbates the visual deficits and optic neuritis elicited by experimental autoimmune encephalomyelitis. Mol Vis. 2016;22:1503-1513 pubmed
  • flow cytometry; mouse; loading ...; fig 4d
Li M, Li Z, Yao Y, Jin W, Wood K, Liu Q, et al. Astrocyte-derived interleukin-15 exacerbates ischemic brain injury via propagation of cellular immunity. Proc Natl Acad Sci U S A. 2017;114:E396-E405 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2a
Wei Y, Lu C, Chen J, Cui G, Wang L, Yu T, et al. High salt diet stimulates gut Th17 response and exacerbates TNBS-induced colitis in mice. Oncotarget. 2017;8:70-82 pubmed publisher
  • flow cytometry; mouse; fig 5a
Moroishi T, Hayashi T, Pan W, Fujita Y, Holt M, Qin J, et al. The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity. Cell. 2016;167:1525-1539.e17 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s5f
Semenkovich N, Planer J, Ahern P, Griffin N, Lin C, Gordon J. Impact of the gut microbiota on enhancer accessibility in gut intraepithelial lymphocytes. Proc Natl Acad Sci U S A. 2016;113:14805-14810 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s3a
Morita K, Okamura T, Inoue M, Komai T, Teruya S, Iwasaki Y, et al. Egr2 and Egr3 in regulatory T cells cooperatively control systemic autoimmunity through Ltbp3-mediated TGF-β3 production. Proc Natl Acad Sci U S A. 2016;113:E8131-E8140 pubmed
  • flow cytometry; mouse; loading ...; fig 1b
Kretzer N, Theisen D, Tussiwand R, Briseño C, Grajales Reyes G, Wu X, et al. RAB43 facilitates cross-presentation of cell-associated antigens by CD8?+ dendritic cells. J Exp Med. 2016;213:2871-2883 pubmed
  • flow cytometry; mouse; loading ...; fig 3a
Brinza L, Djebali S, Tomkowiak M, Mafille J, Loiseau C, Jouve P, et al. Immune signatures of protective spleen memory CD8 T cells. Sci Rep. 2016;6:37651 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1h
Le Q, Yao W, Chen Y, Yan B, Liu C, Yuan M, et al. GRK6 regulates ROS response and maintains hematopoietic stem cell self-renewal. Cell Death Dis. 2016;7:e2478 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s10a
Wang X, Cao Q, Yu L, Shi H, Xue B, Shi H. Epigenetic regulation of macrophage polarization and inflammation by DNA methylation in obesity. JCI Insight. 2016;1:e87748 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 3d
Sektioglu I, Carretero R, Bulbuc N, Bald T, Tüting T, Rudensky A, et al. Basophils Promote Tumor Rejection via Chemotaxis and Infiltration of CD8+ T Cells. Cancer Res. 2017;77:291-302 pubmed publisher
  • flow cytometry; human; loading ...; fig 4c
Srivastava R, Khan A, Garg S, Syed S, Furness J, Vahed H, et al. Human Asymptomatic Epitopes Identified from the Herpes Simplex Virus Tegument Protein VP13/14 (UL47) Preferentially Recall Polyfunctional Effector Memory CD44high CD62Llow CD8+ TEM Cells and Protect Humanized HLA-A*02:01 Transgenic Mice against Ocula. J Virol. 2017;91: pubmed publisher
  • flow cytometry; mouse; loading ...; fig s4a
Laurent C, Dorothee G, Hunot S, Martin E, Monnet Y, Duchamp M, et al. Hippocampal T cell infiltration promotes neuroinflammation and cognitive decline in a mouse model of tauopathy. Brain. 2017;140:184-200 pubmed publisher
  • blocking or activating experiments; mouse; loading ...; fig 6c
  • flow cytometry; mouse; loading ...; fig 5a
Coleman C, Sisk J, Halasz G, Zhong J, Beck S, Matthews K, et al. CD8+ T Cells and Macrophages Regulate Pathogenesis in a Mouse Model of Middle East Respiratory Syndrome. J Virol. 2017;91: pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1a
Calmette J, Bertrand M, Vétillard M, Ellouze M, Flint S, Nicolas V, et al. Glucocorticoid-Induced Leucine Zipper Protein Controls Macropinocytosis in Dendritic Cells. J Immunol. 2016;197:4247-4256 pubmed
  • flow cytometry; mouse; loading ...; fig 3a
Elgueta R, Tse D, Deharvengt S, Luciano M, CARRIERE C, Noelle R, et al. Endothelial Plasmalemma Vesicle-Associated Protein Regulates the Homeostasis of Splenic Immature B Cells and B-1 B Cells. J Immunol. 2016;197:3970-3981 pubmed
  • flow cytometry; mouse; loading ...; fig 2i
Coursey T, Bian F, Zaheer M, Pflugfelder S, Volpe E, de Paiva C. Age-related spontaneous lacrimal keratoconjunctivitis is accompanied by dysfunctional T regulatory cells. Mucosal Immunol. 2017;10:743-756 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s5
Rothchild A, Sissons J, Shafiani S, Plaisier C, Min D, Mai D, et al. MiR-155-regulated molecular network orchestrates cell fate in the innate and adaptive immune response to Mycobacterium tuberculosis. Proc Natl Acad Sci U S A. 2016;113:E6172-E6181 pubmed
  • flow cytometry; mouse; 1:100; fig 10
Carnevale D, Perrotta M, Pallante F, Fardella V, Iacobucci R, Fardella S, et al. A cholinergic-sympathetic pathway primes immunity in hypertension and mediates brain-to-spleen communication. Nat Commun. 2016;7:13035 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1a, 1b
Roncagalli R, Cucchetti M, Jarmuzynski N, Gregoire C, Bergot E, Audebert S, et al. The scaffolding function of the RLTPR protein explains its essential role for CD28 co-stimulation in mouse and human T cells. J Exp Med. 2016;213:2437-2457 pubmed
  • immunohistochemistry - frozen section; mouse; 1:50; loading ...; fig s7g
  • flow cytometry; mouse; loading ...; fig 3f
Kaneda M, Messer K, Ralainirina N, Li H, Leem C, Gorjestani S, et al. PI3Kγ is a molecular switch that controls immune suppression. Nature. 2016;539:437-442 pubmed publisher
  • flow cytometry; mouse; loading ...
Bernard Valnet R, Yshii L, Quériault C, Nguyen X, Arthaud S, Rodrigues M, et al. CD8 T cell-mediated killing of orexinergic neurons induces a narcolepsy-like phenotype in mice. Proc Natl Acad Sci U S A. 2016;113:10956-61 pubmed publisher
  • flow cytometry; mouse; fig 2c
Boddupalli C, Nair S, Gray S, Nowyhed H, Verma R, Gibson J, et al. ABC transporters and NR4A1 identify a quiescent subset of tissue-resident memory T cells. J Clin Invest. 2016;126:3905-3916 pubmed publisher
  • flow cytometry; mouse; loading ...
Olsson A, Venkatasubramanian M, Chaudhri V, Aronow B, Salomonis N, Singh H, et al. Single-cell analysis of mixed-lineage states leading to a binary cell fate choice. Nature. 2016;537:698-702 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 8c
Boucard Jourdin M, Kugler D, Endale Ahanda M, This S, De Calisto J, Zhang A, et al. ?8 Integrin Expression and Activation of TGF-? by Intestinal Dendritic Cells Are Determined by Both Tissue Microenvironment and Cell Lineage. J Immunol. 2016;197:1968-78 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s3a
Liu J, Liu J, Holmström K, Menazza S, Parks R, Fergusson M, et al. MICU1 Serves as a Molecular Gatekeeper to Prevent In Vivo Mitochondrial Calcium Overload. Cell Rep. 2016;16:1561-1573 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 4a
Chow K, Delconte R, Huntington N, Tarlinton D, Sutherland R, Zhan Y, et al. Innate Allorecognition Results in Rapid Accumulation of Monocyte-Derived Dendritic Cells. J Immunol. 2016;197:2000-8 pubmed publisher
  • immunohistochemistry; mouse; fig 1
Raguz J, Jerić I, Niault T, Nowacka J, Kuzet S, Rupp C, et al. Epidermal RAF prevents allergic skin disease. elife. 2016;5: pubmed publisher
  • flow cytometry; mouse; loading ...; fig s3
  • western blot; human; 1:1000; fig 5g
Zhang Y, Velez Delgado A, Mathew E, Li D, Mendez F, Flannagan K, et al. Myeloid cells are required for PD-1/PD-L1 checkpoint activation and the establishment of an immunosuppressive environment in pancreatic cancer. Gut. 2017;66:124-136 pubmed publisher
  • flow cytometry; mouse; fig 2a
Orta Mascaró M, Consuegra Fernández M, Carreras E, Roncagalli R, Carreras Sureda A, Alvarez P, et al. CD6 modulates thymocyte selection and peripheral T cell homeostasis. J Exp Med. 2016;213:1387-97 pubmed publisher
  • immunocytochemistry; mouse; fig 4a
Shen J, Li Z, Li L, Lu L, Xiao Z, Wu W, et al. Vascular-targeted TNF? and IFN? inhibits orthotopic colorectal tumor growth. J Transl Med. 2016;14:187 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s1b
De Grove K, Provoost S, Hendriks R, McKenzie A, Seys L, Kumar S, et al. Dysregulation of type 2 innate lymphoid cells and TH2 cells impairs pollutant-induced allergic airway responses. J Allergy Clin Immunol. 2017;139:246-257.e4 pubmed publisher
  • flow cytometry; mouse; fig s3
Ricard C, Tchoghandjian A, Luche H, Grenot P, Figarella Branger D, Rougon G, et al. Phenotypic dynamics of microglial and monocyte-derived cells in glioblastoma-bearing mice. Sci Rep. 2016;6:26381 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 4c
Rao E, Zhang Y, Li Q, Hao J, Egilmez N, Suttles J, et al. AMPK-dependent and independent effects of AICAR and compound C on T-cell responses. Oncotarget. 2016;7:33783-95 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2a
Chikh G, Luu R, Patel S, Davis H, Weeratna R. Effects of KLK Peptide on Adjuvanticity of Different ODN Sequences. Vaccines (Basel). 2016;4: pubmed publisher
  • flow cytometry; mouse; loading ...; fig s8
Ueno M, Ueno Nakamura Y, Niehaus J, Popovich P, Yoshida Y. Silencing spinal interneurons inhibits immune suppressive autonomic reflexes caused by spinal cord injury. Nat Neurosci. 2016;19:784-7 pubmed publisher
  • flow cytometry; mouse; loading ...
Goldstein J, Burlion A, Zaragoza B, Sendeyo K, Polansky J, Huehn J, et al. Inhibition of the JAK/STAT Signaling Pathway in Regulatory T Cells Reveals a Very Dynamic Regulation of Foxp3 Expression. PLoS ONE. 2016;11:e0153682 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s5a
O Rourke J, Bogdanik L, Yáñez A, Lall D, Wolf A, Muhammad A, et al. C9orf72 is required for proper macrophage and microglial function in mice. Science. 2016;351:1324-9 pubmed publisher
  • flow cytometry; mouse; loading ...; fig s5b
Gomez de Agüero M, Ganal Vonarburg S, Fuhrer T, Rupp S, Uchimura Y, Li H, et al. The maternal microbiota drives early postnatal innate immune development. Science. 2016;351:1296-302 pubmed publisher
  • flow cytometry; mouse; 1:600; fig 2
Miller M, Rosten P, Lemieux M, Lai C, Humphries R. Meis1 Is Required for Adult Mouse Erythropoiesis, Megakaryopoiesis and Hematopoietic Stem Cell Expansion. PLoS ONE. 2016;11:e0151584 pubmed publisher
  • flow cytometry; mouse; fig 2
Catarinella M, Monestiroli A, Escobar G, Fiocchi A, Tran N, Aiolfi R, et al. IFNα gene/cell therapy curbs colorectal cancer colonization of the liver by acting on the hepatic microenvironment. EMBO Mol Med. 2016;8:155-70 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 6a
Ito T, Itakura J, Takahashi S, Sato M, Mino M, Fushimi S, et al. Sprouty-Related Ena/Vasodilator-Stimulated Phosphoprotein Homology 1-Domain-Containing Protein-2 Critically Regulates Influenza A Virus-Induced Pneumonia. Crit Care Med. 2016;44:e530-43 pubmed publisher
  • flow cytometry; mouse; fig 2f
Wei R, Hu Y, Dong F, Xu X, Hu A, Gao G. Hepatoma cell-derived leptin downregulates the immunosuppressive function of regulatory T-cells to enhance the anti-tumor activity of CD8+ T-cells. Immunol Cell Biol. 2016;94:388-99 pubmed publisher
  • flow cytometry; human; 1:200
Riesenberg S, Groetchen A, Siddaway R, Bald T, Reinhardt J, Smorra D, et al. MITF and c-Jun antagonism interconnects melanoma dedifferentiation with pro-inflammatory cytokine responsiveness and myeloid cell recruitment. Nat Commun. 2015;6:8755 pubmed publisher
  • flow cytometry; mouse; fig s2d
Alam M, Gaida M, Bergmann F, Lasitschka F, Giese T, Giese N, et al. Selective inhibition of the p38 alternative activation pathway in infiltrating T cells inhibits pancreatic cancer progression. Nat Med. 2015;21:1337-43 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2b
Manlove L, Berquam Vrieze K, Pauken K, Williams R, Jenkins M, Farrar M. Adaptive Immunity to Leukemia Is Inhibited by Cross-Reactive Induced Regulatory T Cells. J Immunol. 2015;195:4028-37 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 1a
Kaminsky L, Sei J, Parekh N, Davies M, Reider I, Krouse T, et al. Redundant Function of Plasmacytoid and Conventional Dendritic Cells Is Required To Survive a Natural Virus Infection. J Virol. 2015;89:9974-85 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2e
Lowe K, Navarro Núñez L, Bénézech C, Nayar S, Kingston B, Nieswandt B, et al. The expression of mouse CLEC-2 on leucocyte subsets varies according to their anatomical location and inflammatory state. Eur J Immunol. 2015;45:2484-93 pubmed publisher
  • flow cytometry; mouse
Puntambekar S, Hinton D, Yin X, Savarin C, Bergmann C, Trapp B, et al. Interleukin-10 is a critical regulator of white matter lesion containment following viral induced demyelination. Glia. 2015;63:2106-2120 pubmed publisher
  • flow cytometry; mouse
Weindel C, Richey L, Bolland S, Mehta A, Kearney J, Huber B. B cell autophagy mediates TLR7-dependent autoimmunity and inflammation. Autophagy. 2015;11:1010-24 pubmed publisher
  • flow cytometry; mouse
Wang J, Sun C, Gerdes N, Liu C, Liao M, Liu J, et al. Interleukin 18 function in atherosclerosis is mediated by the interleukin 18 receptor and the Na-Cl co-transporter. Nat Med. 2015;21:820-6 pubmed publisher
  • immunohistochemistry; mouse; 1:25
Stermann A, Huebener N, Seidel D, Fest S, Eschenburg G, Stauder M, et al. Targeting of MYCN by means of DNA vaccination is effective against neuroblastoma in mice. Cancer Immunol Immunother. 2015;64:1215-27 pubmed publisher
  • flow cytometry; human
  • flow cytometry; mouse
Holtzhausen A, Zhao F, Evans K, Tsutsui M, Orabona C, Tyler D, et al. Melanoma-Derived Wnt5a Promotes Local Dendritic-Cell Expression of IDO and Immunotolerance: Opportunities for Pharmacologic Enhancement of Immunotherapy. Cancer Immunol Res. 2015;3:1082-95 pubmed publisher
  • flow cytometry; mouse; 1:50; fig 3
Castiglioni A, Corna G, Rigamonti E, Basso V, Vezzoli M, Monno A, et al. FOXP3+ T Cells Recruited to Sites of Sterile Skeletal Muscle Injury Regulate the Fate of Satellite Cells and Guide Effective Tissue Regeneration. PLoS ONE. 2015;10:e0128094 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 2a
Becker P, Hervouet C, Mason G, KWON S, Klavinskis L. Skin vaccination with live virus vectored microneedle arrays induce long lived CD8(+) T cell memory. Vaccine. 2015;33:4691-8 pubmed publisher
  • immunohistochemistry - frozen section; mouse; loading ...; fig ED3d
Kreiter S, Vormehr M, van de Roemer N, Diken M, Löwer M, Diekmann J, et al. Mutant MHC class II epitopes drive therapeutic immune responses to cancer. Nature. 2015;520:692-6 pubmed publisher
  • immunohistochemistry - frozen section; mouse; fig 2
Bian F, Barbosa F, Corrales R, Pelegrino F, Volpe E, Pflugfelder S, et al. Altered balance of interleukin-13/interferon-gamma contributes to lacrimal gland destruction and secretory dysfunction in CD25 knockout model of Sjögren's syndrome. Arthritis Res Ther. 2015;17:53 pubmed publisher
  • flow cytometry; mouse; fig 8
Gardner J, Mamotte C, Patel P, Yeoh T, Jackaman C, Nelson D. Mesothelioma tumor cells modulate dendritic cell lipid content, phenotype and function. PLoS ONE. 2015;10:e0123563 pubmed publisher
  • flow cytometry; mouse; fig s3b, 5g
Martner A, Wiktorin H, Lenox B, Ewald Sander F, Aydin E, Aurelius J, et al. Histamine promotes the development of monocyte-derived dendritic cells and reduces tumor growth by targeting the myeloid NADPH oxidase. J Immunol. 2015;194:5014-21 pubmed publisher
  • flow cytometry; mouse
  • immunocytochemistry; mouse
Boding L, Hansen A, Nielsen M, Meroni G, Braunstein T, Woetmann A, et al. Midline 1 controls polarization and migration of murine cytotoxic T cells. Immun Inflamm Dis. 2014;2:262-71 pubmed publisher
  • immunocytochemistry; mouse; 1:200
Boulay A, Mazeraud A, Cisternino S, Saubaméa B, Mailly P, Jourdren L, et al. Immune quiescence of the brain is set by astroglial connexin 43. J Neurosci. 2015;35:4427-39 pubmed publisher
  • flow cytometry; mouse
Sakala I, Chaudhri G, Eldi P, Buller R, Karupiah G. Deficiency in Th2 cytokine responses exacerbate orthopoxvirus infection. PLoS ONE. 2015;10:e0118685 pubmed publisher
  • other; mouse; fig 2
Okamura T, Sumitomo S, Morita K, Iwasaki Y, Inoue M, Nakachi S, et al. TGF-β3-expressing CD4+CD25(-)LAG3+ regulatory T cells control humoral immune responses. Nat Commun. 2015;6:6329 pubmed publisher
  • flow cytometry; mouse; 1:200
Kanayama M, Inoue M, Danzaki K, Hammer G, He Y, Shinohara M. Autophagy enhances NFκB activity in specific tissue macrophages by sequestering A20 to boost antifungal immunity. Nat Commun. 2015;6:5779 pubmed publisher
  • flow cytometry; mouse; fig 7
Karsten C, Laumonnier Y, Eurich B, Ender F, Bröker K, Roy S, et al. Monitoring and cell-specific deletion of C5aR1 using a novel floxed GFP-C5aR1 reporter knock-in mouse. J Immunol. 2015;194:1841-55 pubmed publisher
  • flow cytometry; mouse
Singh S, Nehete P, Yang G, He H, Nehete B, Hanley P, et al. Enhancement of Mucosal Immunogenicity of Viral Vectored Vaccines by the NKT Cell Agonist Alpha-Galactosylceramide as Adjuvant. Vaccines (Basel). 2014;2:686-706 pubmed publisher
  • flow cytometry; mouse; fig s2
Skripuletz T, Manzel A, Gropengießer K, Schäfer N, Gudi V, Singh V, et al. Pivotal role of choline metabolites in remyelination. Brain. 2015;138:398-413 pubmed publisher
  • flow cytometry; mouse
Rutz S, Kayagaki N, Phung Q, Eidenschenk C, Noubade R, Wang X, et al. Deubiquitinase DUBA is a post-translational brake on interleukin-17 production in T cells. Nature. 2015;518:417-21 pubmed publisher
  • flow cytometry; mouse; fig 4
Frossard C, Asigbetse K, Burger D, Eigenmann P. Gut T cell receptor-γδ(+) intraepithelial lymphocytes are activated selectively by cholera toxin to break oral tolerance in mice. Clin Exp Immunol. 2015;180:118-30 pubmed publisher
  • flow cytometry; mouse; fig 2
Martin P, Dubois C, Jacquier E, Dion S, Mancini Bourgine M, Godon O, et al. TG1050, an immunotherapeutic to treat chronic hepatitis B, induces robust T cells and exerts an antiviral effect in HBV-persistent mice. Gut. 2015;64:1961-71 pubmed publisher
  • flow cytometry; human; fig 2
Svatek R, Zhao X, Morales E, Jha M, Tseng T, Hugen C, et al. Sequential intravesical mitomycin plus Bacillus Calmette-Guérin for non-muscle-invasive urothelial bladder carcinoma: translational and phase I clinical trial. Clin Cancer Res. 2015;21:303-11 pubmed publisher
  • flow cytometry; mouse; fig e4
Venkatanarayan A, Raulji P, Norton W, Chakravarti D, Coarfa C, Su X, et al. IAPP-driven metabolic reprogramming induces regression of p53-deficient tumours in vivo. Nature. 2015;517:626-30 pubmed publisher
  • immunohistochemistry - frozen section; mouse; fig 1
Uchiyama M, Jin X, Yin E, Shimokawa T, Niimi M. Treadmill exercise induces murine cardiac allograft survival and generates regulatory T cell. Transpl Int. 2015;28:352-62 pubmed publisher
  • immunohistochemistry; mouse; fig 1
Taniguchi T, Asano Y, Akamata K, Noda S, Takahashi T, Ichimura Y, et al. Fibrosis, vascular activation, and immune abnormalities resembling systemic sclerosis in bleomycin-treated Fli-1-haploinsufficient mice. Arthritis Rheumatol. 2015;67:517-26 pubmed publisher
  • flow cytometry; mouse
Kern J, Drutel R, Leanhart S, Bogacz M, Pacholczyk R. Reduction of T cell receptor diversity in NOD mice prevents development of type 1 diabetes but not Sjögren's syndrome. PLoS ONE. 2014;9:e112467 pubmed publisher
  • flow cytometry; mouse; loading ...; fig 5
Behler F, Maus R, Bohling J, Knippenberg S, Kirchhof G, Nagata M, et al. Macrophage-inducible C-type lectin Mincle-expressing dendritic cells contribute to control of splenic Mycobacterium bovis BCG infection in mice. Infect Immun. 2015;83:184-96 pubmed publisher
  • flow cytometry; mouse; tbl s1
Sakamoto H, Takeda N, Arai F, Hosokawa K, García P, Suda T, et al. Determining c-Myb protein levels can isolate functional hematopoietic stem cell subtypes. Stem Cells. 2015;33:479-90 pubmed publisher
  • flow cytometry; mouse; fig 5
Naik E, Webster J, DeVoss J, Liu J, Suriben R, Dixit V. Regulation of proximal T cell receptor signaling and tolerance induction by deubiquitinase Usp9X. J Exp Med. 2014;211:1947-55 pubmed publisher
  • immunohistochemistry - frozen section; mouse; fig 3
  • flow cytometry; mouse; fig 6
Kobayashi T, Hamaguchi Y, Hasegawa M, Fujimoto M, Takehara K, Matsushita T. B cells promote tumor immunity against B16F10 melanoma. Am J Pathol. 2014;184:3120-9 pubmed publisher
  • flow cytometry; mouse
Penaloza MacMaster P, Kamphorst A, Wieland A, Araki K, Iyer S, West E, et al. Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection. J Exp Med. 2014;211:1905-18 pubmed publisher
  • immunohistochemistry - frozen section; mouse; fig 2
Ishihara M, Seo N, Mitsui J, Muraoka D, Tanaka M, Mineno J, et al. Systemic CD8+ T cell-mediated tumoricidal effects by intratumoral treatment of oncolytic herpes simplex virus with the agonistic monoclonal antibody for murine glucocorticoid-induced tumor necrosis factor receptor. PLoS ONE. 2014;9:e104669 pubmed publisher
  • flow cytometry; mouse; fig 2
Boding L, Hansen A, Meroni G, Johansen B, Braunstein T, Bonefeld C, et al. Midline 1 directs lytic granule exocytosis and cytotoxicity of mouse killer T cells. Eur J Immunol. 2014;44:3109-18 pubmed publisher
  • flow cytometry; mouse
Knuschke T, Bayer W, Rotan O, Sokolova V, Wadwa M, Kirschning C, et al. Prophylactic and therapeutic vaccination with a nanoparticle-based peptide vaccine induces efficient protective immunity during acute and chronic retroviral infection. Nanomedicine. 2014;10:1787-98 pubmed publisher
  • flow cytometry; mouse
Honjo K, Kubagawa Y, Suzuki Y, Takagi M, Ohno H, Bucy R, et al. Enhanced auto-antibody production and Mott cell formation in Fc?R-deficient autoimmune mice. Int Immunol. 2014;26:659-72 pubmed publisher
  • flow cytometry; mouse
Siurala M, Bramante S, Vassilev L, Hirvinen M, Parviainen S, Tähtinen S, et al. Oncolytic adenovirus and doxorubicin-based chemotherapy results in synergistic antitumor activity against soft-tissue sarcoma. Int J Cancer. 2015;136:945-54 pubmed publisher
  • flow cytometry; mouse
Vargas A, Zhou S, Ethier Chiasson M, Flipo D, Lafond J, Gilbert C, et al. Syncytin proteins incorporated in placenta exosomes are important for cell uptake and show variation in abundance in serum exosomes from patients with preeclampsia. FASEB J. 2014;28:3703-19 pubmed publisher
  • flow cytometry; mouse
Zhang Y, Yan W, Mathew E, Bednar F, Wan S, Collins M, et al. CD4+ T lymphocyte ablation prevents pancreatic carcinogenesis in mice. Cancer Immunol Res. 2014;2:423-35 pubmed publisher
  • flow cytometry; mouse
Ebert S, Becker M, Lemmermann N, Büttner J, Michel A, Taube C, et al. Mast cells expedite control of pulmonary murine cytomegalovirus infection by enhancing the recruitment of protective CD8 T cells to the lungs. PLoS Pathog. 2014;10:e1004100 pubmed publisher
  • flow cytometry; mouse
Pick J, Arra A, Lingel H, Hegel J, Huber M, Nishanth G, et al. CTLA-4 (CD152) enhances the Tc17 differentiation program. Eur J Immunol. 2014;44:2139-52 pubmed publisher
  • flow cytometry; mouse
Cochain C, Chaudhari S, Koch M, Wiendl H, Eckstein H, Zernecke A. Programmed cell death-1 deficiency exacerbates T cell activation and atherogenesis despite expansion of regulatory T cells in atherosclerosis-prone mice. PLoS ONE. 2014;9:e93280 pubmed publisher
  • flow cytometry; mouse
Ntranos A, Hall O, Robinson D, Grishkan I, Schott J, Tosi D, et al. FTY720 impairs CD8 T-cell function independently of the sphingosine-1-phosphate pathway. J Neuroimmunol. 2014;270:13-21 pubmed publisher
  • flow cytometry; mouse
Takei S, Omoto C, Kitagawa K, Morishita N, Katayama T, Shigemura K, et al. Oral administration of genetically modified Bifidobacterium displaying HCV-NS3 multi-epitope fusion protein could induce an HCV-NS3-specific systemic immune response in mice. Vaccine. 2014;32:3066-74 pubmed publisher
  • flow cytometry; mouse
Hirayama T, Asano Y, Iida H, Watanabe T, Nakamura T, Goitsuka R. Meis1 is required for the maintenance of postnatal thymic epithelial cells. PLoS ONE. 2014;9:e89885 pubmed publisher
  • flow cytometry; mouse
Martins K, Steffens J, Van Tongeren S, Wells J, Bergeron A, Dickson S, et al. Toll-like receptor agonist augments virus-like particle-mediated protection from Ebola virus with transient immune activation. PLoS ONE. 2014;9:e89735 pubmed publisher
  • immunohistochemistry - paraffin section; mouse; 1:200; fig 6
Nakahata S, Ichikawa T, Maneesaay P, Saito Y, Nagai K, Tamura T, et al. Loss of NDRG2 expression activates PI3K-AKT signalling via PTEN phosphorylation in ATLL and other cancers. Nat Commun. 2014;5:3393 pubmed publisher
  • flow cytometry; mouse
Gaughan A, Wang J, Pelletier R, Nadasdy T, Brodsky S, Roy S, et al. Key role for CD4 T cells during mixed antibody-mediated rejection of renal allografts. Am J Transplant. 2014;14:284-94 pubmed publisher
  • immunohistochemistry; mouse; 1:2000
Yang M, Rainone A, Shi X, Fournier S, Zhang J. A new animal model of spontaneous autoimmune peripheral polyneuropathy: implications for Guillain-Barré syndrome. Acta Neuropathol Commun. 2014;2:5 pubmed publisher
  • flow cytometry; mouse
Saligrama N, Case L, Krementsov D, Teuscher C. Histamine H₂ receptor signaling × environment interactions determine susceptibility to experimental allergic encephalomyelitis. FASEB J. 2014;28:1898-909 pubmed publisher
  • flow cytometry; mouse
Kim E, Gasper D, Lee S, Plisch E, Svaren J, Suresh M. Bach2 regulates homeostasis of Foxp3+ regulatory T cells and protects against fatal lung disease in mice. J Immunol. 2014;192:985-95 pubmed publisher
  • flow cytometry; mouse
Salem H, Trojanowski B, Fiedler K, Maier H, Schirmbeck R, Wagner M, et al. Long-term IKK2/NF-?B signaling in pancreatic ?-cells induces immune-mediated diabetes. Diabetes. 2014;63:960-75 pubmed publisher
  • flow cytometry; mouse
Iwata A, Kawashima S, Kobayashi M, Okubo A, Kawashima H, Suto A, et al. Th2-type inflammation instructs inflammatory dendritic cells to induce airway hyperreactivity. Int Immunol. 2014;26:103-14 pubmed publisher
  • immunohistochemistry; mouse
Weng T, Huang S, Yen M, Lin C, Chen Y, Lin C, et al. A novel cancer therapeutic using thrombospondin 1 in dendritic cells. Mol Ther. 2014;22:292-302 pubmed publisher
  • flow cytometry; mouse
Toker A, Engelbert D, Garg G, Polansky J, Floess S, Miyao T, et al. Active demethylation of the Foxp3 locus leads to the generation of stable regulatory T cells within the thymus. J Immunol. 2013;190:3180-8 pubmed publisher
  • flow cytometry; mouse
Murapa P, Ward M, Gandhapudi S, Woodward J, D Orazio S. Heat shock factor 1 protects mice from rapid death during Listeria monocytogenes infection by regulating expression of tumor necrosis factor alpha during fever. Infect Immun. 2011;79:177-84 pubmed publisher
  • flow cytometry; mouse
Hu H, Wang B, Borde M, Nardone J, Maika S, Allred L, et al. Foxp1 is an essential transcriptional regulator of B cell development. Nat Immunol. 2006;7:819-26 pubmed
  • flow cytometry; mouse; fig 5
Godfrey D, Kennedy J, Mombaerts P, Tonegawa S, Zlotnik A. Onset of TCR-beta gene rearrangement and role of TCR-beta expression during CD3-CD4-CD8- thymocyte differentiation. J Immunol. 1994;152:4783-92 pubmed
Choi I, Wang Z, Ke Q, Hong M, Qian Y, Zhao X, et al. Signaling by the Epstein-Barr virus LMP1 protein induces potent cytotoxic CD4+ and CD8+ T cell responses. Proc Natl Acad Sci U S A. 2018;115:E686-E695 pubmed publisher
Kanemaru H, Yamane F, Fukushima K, Matsuki T, Kawasaki T, Ebina I, et al. Antitumor effect of Batf2 through IL-12 p40 up-regulation in tumor-associated macrophages. Proc Natl Acad Sci U S A. 2017;114:E7331-E7340 pubmed publisher
Moffitt A, Ondrejka S, McKinney M, Rempel R, Goodlad J, Teh C, et al. Enteropathy-associated T cell lymphoma subtypes are characterized by loss of function of SETD2. J Exp Med. 2017;214:1371-1386 pubmed publisher
Stacey M, Clare S, Clement M, Marsden M, Abdul Karim J, Kane L, et al. The antiviral restriction factor IFN-induced transmembrane protein 3 prevents cytokine-driven CMV pathogenesis. J Clin Invest. 2017;127:1463-1474 pubmed publisher
Li Y, Lu Y, Wang S, Han Z, Zhu F, Ni Y, et al. USP21 prevents the generation of T-helper-1-like Treg cells. Nat Commun. 2016;7:13559 pubmed publisher
Ko E, Lee Y, Kim K, Jung Y, Lee Y, Denning T, et al. Effects of MF59 Adjuvant on Induction of Isotype-Switched IgG Antibodies and Protection after Immunization with T-Dependent Influenza Virus Vaccine in the Absence of CD4+ T Cells. J Virol. 2016;90:6976-6988 pubmed publisher
Wang G, Young S, Bali D, Hutt J, Li S, Benson J, et al. Assessment of toxicity and biodistribution of recombinant AAV8 vector-mediated immunomodulatory gene therapy in mice with Pompe disease. Mol Ther Methods Clin Dev. 2014;1:14018 pubmed publisher
Gillgrass A, Chew M, Krneta T, Ashkar A. Overexpression of IL-15 promotes tumor destruction via NK1.1+ cells in a spontaneous breast cancer model. BMC Cancer. 2015;15:293 pubmed publisher
Day C, Carter J, Weaver Ohler Z, Bonomi C, El Meskini R, Martin P, et al. "Glowing head" mice: a genetic tool enabling reliable preclinical image-based evaluation of cancers in immunocompetent allografts. PLoS ONE. 2014;9:e109956 pubmed publisher
Khalili S, Liu Y, Kornete M, Roescher N, Kodama S, Peterson A, et al. Mesenchymal stromal cells improve salivary function and reduce lymphocytic infiltrates in mice with Sjögren's-like disease. PLoS ONE. 2012;7:e38615 pubmed publisher
Kyaw T, Tay C, Hosseini H, Kanellakis P, Gadowski T, Mackay F, et al. Depletion of B2 but not B1a B cells in BAFF receptor-deficient ApoE mice attenuates atherosclerosis by potently ameliorating arterial inflammation. PLoS ONE. 2012;7:e29371 pubmed publisher
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product information
Cat.# :
550281
Brand :
BD Pharmingen
Name :
CD8a
Format :
Purified
Clone :
53-6.7
Isotype :
Rat IgG 2a
React :
Ms
Conc :
62.5 µg/ml
Apps :
FCM , IHC(Fr) , IHC(Zn
Size :
1 mL
Status :
RUO
more info or order :
company information