ELISA/assay

FGFR4 ELISA Kit (Human) (OKDD00266)

OKDD00266

96 Wells

Application Kit

ELISA Kits

FGFR4 ELISA Kit (Human) (OKDD00266)

96 Wells

FGFR4

CD334, FGFR-4, Fibroblast growth factor receptor 4, JTK2, MGC20292, TKF

NM_001291980.1

NP_001278909.1

P22455

Human

Store as indicated in product manual.

The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 2. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis.

Quantitative Sandwich ELISA

< 0.041 ng/mL

This assay has high sensitivity and excellent specificity for detection of FGFR4. No significant cross-reactivity or interference between FGFR4 and analogues was observed.

Wet Ice

4C