FGFR3 ELISA Kit (Human) (OKDD00265) | Aviva Systems Biology OKDD00265 product information

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product summary

company name :

Aviva Systems Biology

product type :

ELISA/assay

product name :

FGFR3 ELISA Kit (Human) (OKDD00265)

catalog :

OKDD00265

quantity :

96 Wells

product information

sku :

OKDD00265

product type :

Application Kit

category :

ELISA Kits

name :

FGFR3 ELISA Kit (Human) (OKDD00265)

size :

96 Wells

gene symbol :

FGFR3

alias symbols :

ACH, CD333, CEK2, FGFR-3, Fibroblast growth factor receptor 3, HSFGFR3EX, JTK4

nucleotide accession num :

NM_000142.4

protein accession num :

NP_000133.1

swissprot id :

P22607

species reactivity :

Human

reconstitution and storage :

Store as indicated in product manual.

description of target :

This gene encodes a member of the fibroblast growth factor receptor (FGFR) family, with its amino acid sequence being highly conserved between members and among divergent species. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds acidic and basic fibroblast growth hormone and plays a role in bone development and maintenance. Mutations in this gene lead to craniosynostosis and multiple types of skeletal dysplasia. Three alternatively spliced transcript variants that encode different protein isoforms have been described.

assay info :

Quantitative Sandwich ELISA

sensitivity :

< 0.055 ng/mL

specificity :

This assay has high sensitivity and excellent specificity for detection of FGFR3. No significant cross-reactivity or interference between FGFR3 and analogues was observed.

drywet surcharge :

Wet Ice

storage temperature :