HMGB1 Chemi-Luminescent ELISA Kit (Human) (OKCD03560) | Aviva Systems Biology OKCD03560 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Aviva Systems Biology

product type :

ELISA/assay

product name :

HMGB1 Chemi-Luminescent ELISA Kit (Human) (OKCD03560)

catalog :

OKCD03560

quantity :

96 Wells

product information

sku :

OKCD03560

product type :

Application Kit

category :

ELISA Kits

name :

HMGB1 Chemi-Luminescent ELISA Kit (Human) (OKCD03560)

size :

96 Wells

gene symbol :

HMGB1

alias symbols :

DKFZp686A04236, high-mobility group box 1, High mobility group protein 1, High mobility group protein B1, HMG1, HMG-1, HMG3, SBP-1

nucleotide accession num :

NM_001313892

protein accession num :

NP_001300821

swissprot id :

P09429

species reactivity :

Human

reconstitution and storage :

Store as indicated in product manual.

description of target :

Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functions as sensor and/or chaperone for immunogenic nucleic acids implicating the activation of TLR9-mediated immune responses, and mediates autophagy. Acts as danger associated molecular pattern (DAMP) molecule that amplifies immune responses during tissue injury . Released to the extracellular environment can bind DNA, nucleosomes, IL-1 beta, CXCL12, AGER isoform 2/sRAGE, lipopolysaccharide (LPS) and lipoteichoic acid (LTA), and activates cells through engagement of multiple surface receptors. In the extracellular compartment fully reduced HMGB1 (released by necrosis) acts as a chemokine, disulfide HMGB1 (actively secreted) as a cytokine, and sulfonyl HMGB1 (released from apoptotic cells) promotes immunological tolerance . Has proangiogdenic activity . May be involved in platelet activation . Binds to phosphatidylserine and phosphatidylethanolamide . Bound to RAGE mediates signaling for neuronal outgrowth . May play a role in accumulation of expanded polyglutamine (polyQ) proteins such as huntingtin (HTT) or TBP .

assay info :

Assay Methodology: Quantitative Sandwich ELISA

sensitivity :

13.7 pg/mL

drywet surcharge :

Wet Ice

storage temperature :

2-8C