TRPV1 ELISA Kit (Mouse) (OKCD02958) | Aviva Systems Biology OKCD02958 product information

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product summary

company name :

Aviva Systems Biology

product type :

ELISA/assay

product name :

TRPV1 ELISA Kit (Mouse) (OKCD02958)

catalog :

OKCD02958

quantity :

96 Wells

product information

sku :

OKCD02958

product type :

Application Kit

category :

ELISA Kits

name :

TRPV1 ELISA Kit (Mouse) (OKCD02958)

size :

96 Wells

gene symbol :

TRPV1

alias symbols :

capsaicin receptor, Osm-9-like TRP channel 1, OTRPC1, Transient receptor potential cation channel subfamily V member 1, TrpV1, TRPV1alpha, TRPV1beta, Vanilloid receptor 1, Vr1, VR-1

nucleotide accession num :

NM_001001445.2

protein accession num :

NP_001001445.1

swissprot id :

Q704Y3

species reactivity :

Mouse

reconstitution and storage :

Store as indicated in product manual.

description of target :

Ligand-activated non-selective calcium permeant cation channel involved in detection of noxious chemical and thermal stimuli. Seems to mediate proton influx and may be involved in intracellular acidosis in nociceptive neurons. Involved in mediation of inflammatory pain and hyperalgesia. Sensitized by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases, which involves PKC isozymes and PCL. Activation by vanilloids, like capsaicin, and temperatures higher than 42 degrees Celsius, exhibits a time- and Ca2+-dependent outward rectification, followed by a long-lasting refractory state. Mild extracellular acidic pH (6.5) potentiates channel activation by noxious heat and vanilloids, whereas acidic conditions (pH 6) directly activate the channel. Can be activated by endogenous compounds, including 12-hydroperoxytetraenoic acid and bradykinin. Acts as ionotropic endocannabinoid receptor with central neuromodulatory effects. Triggers a form of long-term depression (TRPV1-LTD) mediated by the endocannabinoid anandamine in the hippocampus and nucleus accumbens by affecting AMPA receptors endocytosis.

assay info :

Assay Methodology: Quantitative Sandwich ELISA

sensitivity :

0.055 ng/mL

specificity :

This assay has high sensitivity and excellent specificity for detection of Transient Receptor Potential Cation Channel Subfamily V, Member 1 (TRPV1). No significant cross-reactivity or interference between Transient Receptor Potential Cation Channel Subfamily V, Member 1 (TRPV1) and analogues was observed.

drywet surcharge :

Wet Ice

storage temperature :

2-8C