PSAP ELISA Kit (Human) (OKCD02827) | Aviva Systems Biology OKCD02827 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Aviva Systems Biology

product type :

ELISA/assay

product name :

PSAP ELISA Kit (Human) (OKCD02827)

catalog :

OKCD02827

quantity :

96 Wells

product information

sku :

OKCD02827

product type :

Application Kit

category :

ELISA Kits

name :

PSAP ELISA Kit (Human) (OKCD02827)

size :

96 Wells

gene symbol :

PSAP

alias symbols :

FLJ00245, GLBA, MGC110993, Proactivator polypeptide, SAP1

nucleotide accession num :

NM_001042465.2

protein accession num :

NP_001035930.1

swissprot id :

P07602

species reactivity :

Human

reconstitution and storage :

Store as indicated in product manual.

description of target :

Saposin-A and saposin-C stimulate the hydrolysis of glucosylceramide by beta-glucosylceramidase (EC 3.2.1.45) and galactosylceramide by beta-galactosylceramidase (EC 3.2.1.46). Saposin-C apparently acts by combining with the enzyme and acidic lipid to form an activated complex, rather than by solubilizing the substrate. Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A (EC 3.1.6.8), GM1 gangliosides by beta-galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha-galactosidase A (EC 3.2.1.22). Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases. Saposin-D is a specific sphingomyelin phosphodiesterase activator (EC 3.1.4.12). Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling.

assay info :

Assay Methodology: Quantitative Sandwich ELISA

sensitivity :

<0.059 ng/mL

specificity :

This assay has high sensitivity and excellent specificity for detection of Prosaposin (PSAP). No significant cross-reactivity or interference between Prosaposin (PSAP) and analogues was observed.

drywet surcharge :

Wet Ice

storage temperature :

2-8C