PCNA ELISA Kit (Human) (OKCD02760) | Aviva Systems Biology OKCD02760 product information

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product summary

company name :

Aviva Systems Biology

product type :

ELISA/assay

product name :

PCNA ELISA Kit (Human) (OKCD02760)

catalog :

OKCD02760

quantity :

96 Wells

product information

sku :

OKCD02760

product type :

Application Kit

category :

ELISA Kits

name :

PCNA ELISA Kit (Human) (OKCD02760)

size :

96 Wells

gene symbol :

PCNA

alias symbols :

Cyclin, Proliferating cell nuclear antigen

nucleotide accession num :

NM_002592.2

protein accession num :

NP_002583.1

swissprot id :

P12004

species reactivity :

Human

reconstitution and storage :

Store as indicated in product manual.

description of target :

Auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. Induces a robust stimulatory effect on the 3'-5' exonuclease and 3'-phosphodiesterase, but not apurinic-apyrimidinic (AP) endonuclease, APEX2 activities. Has to be loaded onto DNA in order to be able to stimulate APEX2. Plays a key role in DNA damage response (DDR) by being conveniently positioned at the replication fork to coordinate DNA replication with DNA repair and DNA damage tolerance pathways. Acts as a loading platform to recruit DDR proteins that allow completion of DNA replication after DNA damage and promote postreplication repair: Monoubiquitinated PCNA leads to recruitment of translesion (TLS) polymerases, while 'Lys-63'-linked polyubiquitination of PCNA is involved in error-free pathway and employs recombination mechanisms to synthesize across the lesion.

assay info :

Assay Methodology: Quantitative Sandwich ELISA

sensitivity :

0.055 ng/mL

specificity :

This assay has high sensitivity and excellent specificity for detection of Proliferating Cell Nuclear Antigen (PCNA). No significant cross-reactivity or interference between Proliferating Cell Nuclear Antigen (PCNA) and analogues was observed.

drywet surcharge :

Wet Ice

storage temperature :

2-8C