SATB1 ELISA Kit (Human) (OKCD02025) | Aviva Systems Biology OKCD02025 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Aviva Systems Biology

product type :

ELISA/assay

product name :

SATB1 ELISA Kit (Human) (OKCD02025)

catalog :

OKCD02025

quantity :

96 Wells

product information

sku :

OKCD02025

product type :

Application Kit

category :

ELISA Kits

name :

SATB1 ELISA Kit (Human) (OKCD02025)

size :

96 Wells

gene symbol :

SATB1

alias symbols :

DNA-binding protein SATB1, Special AT-rich sequence-binding protein 1

nucleotide accession num :

NM_001131010.3

protein accession num :

NP_001124482.1

swissprot id :

Q01826

species reactivity :

Human

reconstitution and storage :

Store as indicated in product manual.

description of target :

Crucial silencing factor contributing to the initiation of X inactivation mediated by Xist RNA that occurs during embryogenesis and in lymphoma. Binds to DNA at special AT-rich sequences, the consensus SATB1-binding sequence (CSBS), at nuclear matrix- or scaffold-associated regions. Thought to recognize the sugar-phosphate structure of double-stranded DNA. Transcriptional repressor controlling nuclear and viral gene expression in a phosphorylated and acetylated status-dependent manner, by binding to matrix attachment regions (MARs) of DNA and inducing a local chromatin-loop remodeling. Acts as a docking site for several chromatin remodeling enzymes (e.g. PML at the MHC-I locus) and also by recruiting corepressors (HDACs) or coactivators (HATs) directly to promoters and enhancers. Modulates genes that are essential in the maturation of the immune T-cell CD8SP from thymocytes. Required for the switching of fetal globin species, and beta- and gamma-globin genes regulation during erythroid differentiation. Plays a role in chromatin organization and nuclear architecture during apoptosis. Interacts with the unique region (UR) of cytomegalovirus (CMV). Alu-like motifs and SATB1-binding sites provide a unique chromatin context which seems preferentially targeted by the HIV-1 integration machinery. Moreover, HIV-1 Tat may overcome SATB1-mediated repression of IL2 and IL2RA (interleukin) in T-cells by binding to the same domain than HDAC1. Delineates specific epigenetic modifications at target gene loci, directly up-regulating metastasis-associated genes while down-regulating tumor-suppressor genes. Reprograms chromatin organization and the transcription profiles of breast tumors to promote growth and metastasis.

assay info :

Assay Methodology: Quantitative Sandwich Immunoassay

sensitivity :

< 0.102 ng/mL

specificity :

This assay has high sensitivity and excellent specificity for detection of SATB Homeobox Protein 1 (SATB1). No significant cross-reactivity or interference between SATB Homeobox Protein 1 (SATB1) and analogues was observed.

drywet surcharge :

Wet Ice

storage temperature :

2-8C