RASSF1 ELISA Kit (Human) (OKCD02023) | Aviva Systems Biology OKCD02023 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Aviva Systems Biology

product type :

ELISA/assay

product name :

RASSF1 ELISA Kit (Human) (OKCD02023)

catalog :

OKCD02023

quantity :

96 Wells

product information

sku :

OKCD02023

product type :

Application Kit

category :

ELISA Kits

name :

RASSF1 ELISA Kit (Human) (OKCD02023)

size :

96 Wells

gene symbol :

RASSF1

alias symbols :

123F2, NORE2A, Ras association domain-containing protein 1, RASSF1A, RDA32, REH3P21

nucleotide accession num :

NM_001206957.1

protein accession num :

NP_001193886.1

swissprot id :

Q9NS23

species reactivity :

Human

reconstitution and storage :

Store as indicated in product manual.

description of target :

Potential tumor suppressor. Required for death receptor-dependent apoptosis. Mediates activation of STK3/MST2 and STK4/MST1 during Fas-induced apoptosis by preventing their dephosphorylation. When associated with MOAP1, promotes BAX conformational change and translocation to mitochondrial membranes in response to TNF and TNFSF1 stimulation. Isoform A interacts with CDC2, an activator of the anaphase-promoting complex, APC, resulting in the inhibition of APC activity and mitotic progression. Inhibits proliferation by negatively regulating cell cycle progression at the level of G1/S-phase transition by regulating accumulation of cyclin D1 protein. Isoform C has been shown not to perform these roles, no function has been identified for this isoform. Isoform A disrupts interactions among MDM2, DAXX and USP7, thus contributing to the efficient activation of TP53 by promoting MDM2 self-ubiquitination in cell-cycle checkpoint control in response to DNA damage.

assay info :

Assay Methodology: Quantitative Sandwich Immunoassay

sensitivity :

< 0.059 ng/mL

specificity :

This assay has high sensitivity and excellent specificity for detection of Ras Association Domain Containing Protein 1 (RASSF1). No significant cross-reactivity or interference between Ras Association Domain Containing Protein 1 (RASSF1) and analogues was observed.

drywet surcharge :

Wet Ice

storage temperature :

2-8C