OGT ELISA Kit (Human) (OKCD01956) | Aviva Systems Biology OKCD01956 product information

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product summary

company name :

Aviva Systems Biology

product type :

ELISA/assay

product name :

OGT ELISA Kit (Human) (OKCD01956)

catalog :

OKCD01956

quantity :

96 Wells

product information

sku :

OKCD01956

product type :

Application Kit

category :

ELISA Kits

name :

OGT ELISA Kit (Human) (OKCD01956)

size :

96 Wells

gene symbol :

OGT

alias symbols :

FLJ23071, HRNT1, MGC22921, O-GLCNAC, O-GlcNAc transferase subunit p110, O-linked N-acetylglucosamine transferase 110 kDa subunit, UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

nucleotide accession num :

NM_181672.2

protein accession num :

NP_858058.1

swissprot id :

O15294

species reactivity :

Human

reconstitution and storage :

Store as indicated in product manual.

description of target :

Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in cytoplasmic and nuclear proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Glycosylates a large and diverse number of proteins including histone H2B, AKT1, EZH2, PFKL, KMT2E/MLL5, MAPT/TAU and HCFC1. Can regulate their cellular processes via cross-talk between glycosylation and phosphorylation or by affecting proteolytic processing. Involved in insulin resistance in muscle and adipocyte cells via glycosylating insulin signaling components and inhibiting the 'Thr-38' phosphorylation of AKT1, enhancing IRS1 phosphorylation and attenuating insulin signaling. Involved in glycolysis regulation by mediating glycosylation of 6-phosphofructokinase PFKL, inhibiting its activity.

assay info :

Assay Methodology: Quantitative Sandwich Immunoassay

sensitivity :

< 0.59 ng/mL

specificity :

This assay has high sensitivity and excellent specificity for detection of O-Linked-N-Acetylglucosamine Transferase (OGT). No significant cross-reactivity or interference between O-Linked-N-Acetylglucosamine Transferase (OGT) and analogues was observed.

drywet surcharge :

Wet Ice

storage temperature :

2-8C