MBP High Sensitivity ELISA Kit (Human) (OKCD01323) | Aviva Systems Biology OKCD01323 product information

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product summary

company name :

Aviva Systems Biology

product type :

ELISA/assay

product name :

MBP High Sensitivity ELISA Kit (Human) (OKCD01323)

catalog :

OKCD01323

quantity :

96 Wells

product information

sku :

OKCD01323

product type :

Application Kit

category :

ELISA Kits

name :

MBP High Sensitivity ELISA Kit (Human) (OKCD01323)

size :

96 Wells

gene symbol :

MBP

alias symbols :

Myelin A1 protein, Myelin basic protein, Myelin membrane encephalitogenic protein

nucleotide accession num :

NM_001025081.1

protein accession num :

NP_001020252.1

swissprot id :

P02686

species reactivity :

Human

reconstitution and storage :

Store as indicated in product manual.

description of target :

The classic group of MBP isoforms (isoform 4-isoform 14) are with PLP the most abundant protein components of the myelin membrane in the CNS. They have a role in both its formation and stabilization. The smaller isoforms might have an important role in remyelination of denuded axons in multiple sclerosis. The non-classic group of MBP isoforms (isoform 1-isoform 3/Golli-MBPs) may preferentially have a role in the early developing brain long before myelination, maybe as components of transcriptional complexes, and may also be involved in signaling pathways in T-cells and neural cells. Differential splicing events combined with optional post-translational modifications give a wide spectrum of isomers, with each of them potentially having a specialized function. Induces T-cell proliferation.

assay info :

Assay Methodology: Quantitative Sandwich ELISA

sensitivity :

6.4 pg/mL

specificity :

This assay has high sensitivity and excellent specificity for detection of Myelin Basic Protein (MBP). No significant cross-reactivity or interference between Myelin Basic Protein (MBP) and analogues was observed.

drywet surcharge :

Wet Ice

storage temperature :

2-8C