WWP2 ELISA Kit (Human) (OKCD01268) | Aviva Systems Biology OKCD01268 product information

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product summary

company name :

Aviva Systems Biology

product type :

ELISA/assay

product name :

WWP2 ELISA Kit (Human) (OKCD01268)

catalog :

OKCD01268

quantity :

96 Wells

product information

sku :

OKCD01268

product type :

Application Kit

category :

ELISA Kits

name :

WWP2 ELISA Kit (Human) (OKCD01268)

size :

96 Wells

gene symbol :

WWP2

alias symbols :

AIP2, Atrophin-1-interacting protein 2, NEDD4-like E3 ubiquitin-protein ligase WWP2, WW domain-containing protein 2, WWp2-like

nucleotide accession num :

NM_001270453.1

protein accession num :

NP_001257382

swissprot id :

O00308

species reactivity :

Human

reconstitution and storage :

Store as indicated in product manual.

description of target :

E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Polyubiquitinates POU5F1 by 'Lys-63'-linked conjugation and promotes it to proteasomal degradation; in embryonic stem cells (ESCs) the ubiquitination is proposed to regulate POU5F1 protein level. Ubiquitinates EGR2 and promotes it to proteasomal degradation; in T-cells the ubiquitination inhibits activation-induced cell death. Ubiquitinates SLC11A2; the ubiquitination is enhanced by presence of NDFIP1 and NDFIP2. Ubiquitinates RPB1 and promotes it to proteasomal degradation.2 Publications p>Manually curated information for which there is published experimental evidence. /p> a href="/manual/evidences#ECO:269">MoreÃ¢â‚¬Â¦ /a> /p> Manual assertion based on experiment iniRef.13"WWP2 promotes degradation of transcription factor OCT4 in human embryonic stem cells." Xu H., Wang W., Li C., Yu H., Yang A., Wang B., Jin Y. Cell Res. 19:561-573(29) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION IN UBIQUITINATION OF POU5F1, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, INTERACTION WITH POU5F1, MUTAGENESIS OF CYS-838.Ref.15"The HECT-type E3 ubiquitin ligase AIP2 inhibits activation-induced T-cell death by catalyzing EGR2 ubiquitination." Chen A., Gao B., Zhang J., McEwen T., Ye S.Q., Zhang D., Fang D. Mol. Cell. Biol. 29:5348-5356(29) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION IN UBIQUITINATION OF EGR2, INTERACTION WITH EGR2.

application :

ELISA

assay info :

Assay Methodology: Quantitative Sandwich Immunoassay

sensitivity :

< 0.27 ng/mL

specificity :

This assay has high sensitivity and excellent specificity for detection of WW Domain Containing E3 Ubiquitin Protein Ligase 2 (WWP2). No significant cross-reactivity or interference between WW Domain Containing E3 Ubiquitin Protein Ligase 2 (WWP2) and analogues was observed.

drywet surcharge :

Wet Ice

storage temperature :