IGF1 ELISA Kit (Rabbit) (OKCD01184) | Aviva Systems Biology OKCD01184 product information

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product summary

company name :

Aviva Systems Biology

product type :

ELISA/assay

product name :

IGF1 ELISA Kit (Rabbit) (OKCD01184)

catalog :

OKCD01184

quantity :

96 Wells

product information

sku :

OKCD01184

product type :

Application Kit

category :

ELISA Kits

name :

IGF1 ELISA Kit (Rabbit) (OKCD01184)

size :

96 Wells

gene symbol :

IGF1

alias symbols :

IGFI, IGF1A, IBP1, MGF, Somatomedin C, Mechano Growth Gactor

nucleotide accession num :

XM_014119232.1

protein accession num :

XP_013974707

swissprot id :

Q95222

species reactivity :

Rabbit

reconstitution and storage :

Store as indicated in product manual.

description of target :

The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca2+-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb. Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiatiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (By similarity).By similarity p>Manually curated information which has been propagated from a related experimentally characterized protein. /p> a href="/manual/evidences#ECO:25">MoreÃ¢â‚¬Â¦ /a> /p> Manual assertion inferred from sequence similarity toiUniProtKB:P517 (IGF1_MOUSE)UniProtKB:P519 (IGF1_HUMAN)

application :

ELISA

assay info :

Assay Methodology: Quantitative Sandwich Immunoassay

sensitivity :

< 35 pg/mL

specificity :

This assay has high sensitivity and excellent specificity for detection of Insulin Like Growth Factor 1 (IGF1). No significant cross-reactivity or interference between Insulin Like Growth Factor 1 (IGF1) and analogues was observed.

drywet surcharge :

Wet Ice

storage temperature :