EZH1 ELISA Kit (Human) (OKCD01063) | Aviva Systems Biology OKCD01063 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Aviva Systems Biology

product type :

ELISA/assay

product name :

EZH1 ELISA Kit (Human) (OKCD01063)

catalog :

OKCD01063

quantity :

96 Wells

product information

sku :

OKCD01063

product type :

Application Kit

category :

ELISA Kits

name :

EZH1 ELISA Kit (Human) (OKCD01063)

size :

96 Wells

gene symbol :

EZH1

alias symbols :

Enhancer of zeste homolog 1, ENX-2, Histone-lysine N-methyltransferase EZH1, KIAA0388, KMT6B

nucleotide accession num :

NM_001321079.1

protein accession num :

NP_001308008

swissprot id :

Q92800

species reactivity :

Human

reconstitution and storage :

Store as indicated in product manual.

description of target :

Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation.1 Publication p>Manually curated information for which there is published experimental evidence. /p> a href="/manual/evidences#ECO:269">MoreÃ¢â‚¬Â¦ /a> /p> Manual assertion based on experiment iniRef.1"Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms." Margueron R., Li G., Sarma K., Blais A., Zavadil J., Woodcock C.L., Dynlacht B.D., Reinberg D. Mol. Cell 32:53-518(28) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, CATALYTIC ACTIVITY, SUBCELLULAR LOCATION, IDENTIFICATION IN THE PRC2/EED-EZH1 COMPLEX, MUTAGENESIS OF HIS-69.

application :

ELISA

assay info :

Assay Methodology: Quantitative Sandwich Immunoassay

sensitivity :

< 0.113 ng/mL

specificity :

This assay has high sensitivity and excellent specificity for detection of Enhancer Of Zeste Homolog 1 (EZH1). No significant cross-reactivity or interference between Enhancer Of Zeste Homolog 1 (EZH1) and analogues was observed.

drywet surcharge :

Wet Ice

storage temperature :