ELISA/assay

PTPN6 ELISA Kit (Human) (OKCD00911)

OKCD00911

96 Wells

Application Kit

ELISA Kits

PTPN6 ELISA Kit (Human) (OKCD00911)

96 Wells

PTPN6

HCP, HCPH, Hematopoietic cell protein-tyrosine phosphatase, HPTP1C, Protein-tyrosine phosphatase 1C, Protein-tyrosine phosphatase SHP-1, PTP1C, PTP-1C, SHP1, SHP-1, SHP-1L, SH-PTP1, Tyrosine-protein phosphatase non-receptor type 6

NM_002831.5

NP_002822

P29350

Human

Store as indicated in product manual.

Modulates signaling by tyrosine phosphorylated cell surface receptors such as KIT and the EGF receptor/EGFR. The SH2 regions may interact with other cellular components to modulate its own phosphatase activity against interacting substrates. Together with MTUS1, induces UBE2V2 expression upon angiotensin II stimulation. Plays a key role in hematopoiesis.1 Publication p>Manually curated information for which there is published experimental evidence. /p> a href="/manual/evidences#ECO:269">More… /a> /p> Manual assertion based on experiment iniRef.2"Negative regulation of Ros receptor tyrosine kinase signaling. An epithelial function of the SH2 domain protein tyrosine phosphatase SHP-1." Keilhack H., Mueller M., Boehmer S.A., Frank C., Weidner K.M., Birchmeier W., Ligensa T., Berndt A., Kosmehl H., Guenther B., Mueller T., Birchmeier C., Boehmer F.D. J. Cell Biol. 152:325-334(21) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION IN ROS1 DEPHOSPHORYLATION, INTERACTION WITH ROS1.

ELISA

Assay Methodology: Quantitative Sandwich Immunoassay

< 0.105 ng/mL

This assay has high sensitivity and excellent specificity for detection of Protein Tyrosine Phosphatase, Non Receptor Type 6 (PTPN6). No significant cross-reactivity or interference between Protein Tyrosine Phosphatase, Non Receptor Type 6 (PTPN6) and analogues was observed.

Wet Ice

4C