ELISA/assay

SLAMF7 ELISA Kit (Human) (OKCD00598)

OKCD00598

96 Wells

Application Kit

ELISA Kits

SLAMF7 ELISA Kit (Human) (OKCD00598)

96 Wells

SLAMF7

19A, CD2-like receptor-activating cytotoxic cells, CD2 subset 1, CD319, CRACC, CS1, Membrane protein FOAP-12, Novel Ly9, Protein 19A, UNQ576/PRO1138

NM_001282588.1

NP_001269517

Q9NQ25

Human

Store as indicated in product manual.

Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (PubMed:11698418). Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K (PubMed:16339536). In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells (By similarity). May play a role in lymphocyte adhesion (PubMed:1182771). In LPS-activated monocytes negatively regulates production of proinflammatory cytokines (PubMed:23695528).By similarity p>Manually curated information which has been propagated from a related experimentally characterized protein. /p> a href="/manual/evidences#ECO:25">More… /a> /p> Manual assertion inferred from sequence similarity toiUniProtKB:Q8BHK6 (SLAF7_MOUSE)5 Publications p>Manually curated information for which there is published experimental evidence. /p> a href="/manual/evidences#ECO:269">More… /a> /p> Manual assertion based on experiment iniRef.2"Activation of NK cell-mediated cytotoxicity by a SAP-independent receptor of the CD2 family." Bouchon A., Cella M., Grierson H.L., Cohen J.I., Colonna M. J. Immunol. 167:5517-5521(21) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.Ref.3"A novel immunoglobulin superfamily receptor (19A) related to CD2 is expressed on activated lymphocytes and promotes homotypic B-cell adhesion." Murphy J.J., Hobby P., Vilarino-Varela J., Bishop B., Iordanidou P., Sutton B.J., Norton J.D. Biochem. J. 361:431-436(22) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 3), FUNCTION, TISSUE SPECIFICITY.Ref.4"Homo sapiens mRNA for FOAP-12 protein, complete cds." Fujii Y., Takayama K., Tsuritani K., Yajima Y., Amemiya T., Ukai Y., Naito K., Kawaguchi A. Submitted (MAY-1999) to the EMBL/GenBank/DDBJ databasesCited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).Ref.14"The cytotoxicity receptor CRACC (CS-1) recruits EAT-2 and activates the PI3K and phospholipase Cgamma signaling pathways in human NK cells." Tassi I., Colonna M. J. Immunol. 175:7996-82(25) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INTERACTION WITH SH2D1B.Ref.15"CS1 (SLAMF7) inhibits production of proinflammatory cytokines by activated monocytes." Kim J.R., Horton N.C., Mathew S.O., Mathew P.A. Inflamm. Res. 62:765-772(213) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, TISSUE SPECIFICITY. Isoform 3 does not mediate any NK cell activation.

ELISA

Assay Methodology: Quantitative Sandwich Immunoassay

< 0.055 ng/mL

This assay has high sensitivity and excellent specificity for detection of Signaling Lymphocytic Activation Molecule Family, Member 7 (SLAMF7). No significant cross-reactivity or interference between Signaling Lymphocytic Activation Molecule Family, Member 7 (SLAMF7) and analogues was observed.

Wet Ice

4C