MFN1 ELISA Kit (Human) (OKCD00342) | Aviva Systems Biology OKCD00342 product information

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product summary

company name :

Aviva Systems Biology

product type :

ELISA/assay

product name :

MFN1 ELISA Kit (Human) (OKCD00342)

catalog :

OKCD00342

quantity :

96 Wells

product information

sku :

OKCD00342

product type :

Application Kit

category :

ELISA Kits

name :

MFN1 ELISA Kit (Human) (OKCD00342)

size :

96 Wells

gene symbol :

MFN1

alias symbols :

DKFZp762F247, FLJ20693, Fzo homolog, hfzo1, hfzo2, MGC41806, Mitofusin-1, Transmembrane GTPase MFN1

nucleotide accession num :

NM_033540.2

protein accession num :

NP_284941

swissprot id :

Q8IWA4

species reactivity :

Human

reconstitution and storage :

Store as indicated in product manual.

description of target :

Essential transmembrane GTPase, which mediates mitochondrial fusion. Fusion of mitochondria occurs in many cell types and constitutes an important step in mitochondria morphology, which is balanced between fusion and fission. MFN1 acts independently of the cytoskeleton. Overexpression induces the formation of mitochondrial networks.4 Publications p>Manually curated information for which there is published experimental evidence. /p> a href="/manual/evidences#ECO:269">MoreÃ¢â‚¬Â¦ /a> /p> Manual assertion based on experiment iniRef.1"Control of mitochondrial morphology by a human mitofusin." Santel A., Fuller M.T. J. Cell Sci. 114:867-874(21) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, VARIANT ARG-523.Ref.1"Mitochondrial fusion in human cells is efficient, requires the inner membrane potential, and is mediated by mitofusins." Legros F., Lombes A., Frachon P., Rojo M. Mol. Biol. Cell 13:4343-4354(22) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION.Ref.11"Mitofusin-1 protein is a generally expressed mediator of mitochondrial fusion in mammalian cells." Santel A., Frank S., Gaume B., Herrler M., Youle R.J., Fuller M.T. J. Cell Sci. 116:2763-2774(23) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, MUTAGENESIS OF LYS-88 AND THR-19.Ref.14"MiD49 and MiD51 can act independently of Mff and Fis1 in Drp1 recruitment and are specific for mitochondrial fission." Palmer C.S., Elgass K.D., Parton R.G., Osellame L.D., Stojanovski D., Ryan M.T. J. Biol. Chem. 288:27584-27593(213) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION.

application :

ELISA

assay info :

Assay Methodology: Quantitative Sandwich Immunoassay

sensitivity :

< 0.059 ng/mL

specificity :

This assay has high sensitivity and excellent specificity for detection of Mitofusin 1 (MFN1). No significant cross-reactivity or interference between Mitofusin 1 (MFN1) and analogues was observed.

drywet surcharge :

Wet Ice

storage temperature :