ELISA/assay

IL36RN ELISA Kit (Human) (OKCD00166)

OKCD00166

96 Wells

Application Kit

ELISA Kits

IL36RN ELISA Kit (Human) (OKCD00166)

96 Wells

IL36RN

FIL1, FIL1(DELTA), FIL1D, FIL1 delta, IL-1 delta, IL-1F5, IL1HY1, IL-1HY1, IL1L1, IL-1L1, IL-1ra homolog 1, IL-1-related protein 3, IL1RP3, IL-1RP3, Interleukin-1 delta, Interleukin-1 family member 5, Interleukin-1 HY1, Interleukin-1-like protein 1, Inter

NM_012275.2

NP_036407

Q9UBH0

Human

Store as indicated in product manual.

Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR.3 Publications p>Manually curated information for which there is published experimental evidence. /p> a href="/manual/evidences#ECO:269">More… /a> /p> Manual assertion based on experiment iniRef.4"Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2." Debets R., Timans J.C., Homey B., Zurawski S., Sana T.R., Lo S., Wagner J., Edwards G., Clifford T., Menon S., Bazan J.F., Kastelein R.A. J. Immunol. 167:144-1446(21) [PubMed] [Europe PMC] [Abstract]Cited for: NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, TISSUE SPECIFICITY.Ref.13"Interleukin-36 (IL-36) ligands require processing for full agonist (IL-36alpha, IL-36beta, and IL-36gamma) or antagonist (IL-36Ra) activity." Towne J.E., Renshaw B.R., Douangpanya J., Lipsky B.P., Shen M., Gabel C.A., Sims J.E. J. Biol. Chem. 286:42594-4262(211) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, CLEAVAGE OF INITIATOR METHIONINE.Ref.14"The IL-36 receptor pathway regulates Aspergillus fumigatus-induced Th1 and Th17 responses." Gresnigt M.S., Roesler B., Jacobs C.W., Becker K.L., Joosten L.A., van der Meer J.W., Netea M.G., Dinarello C.A., van de Veerdonk F.L. Eur. J. Immunol. 43:416-426(213) [PubMed] [Europe PMC] [Abstract]Cited for: FUNCTION, INDUCTION.

ELISA

Assay Methodology: Quantitative Sandwich Immunoassay

< 5.9 pg/mL

This assay has high sensitivity and excellent specificity for detection of Interleukin 1 Delta (FIL1d). No significant cross-reactivity or interference between Interleukin 1 Delta (FIL1d) and analogues was observed.

Wet Ice

4C