ELISA/assay

TGFB1 ELISA Kit (Dog) (OKCD00149)

OKCD00149

96 Wells

Application Kit

ELISA Kits

TGFB1 ELISA Kit (Dog) (OKCD00149)

96 Wells

TGFB1

TGF-B1, CED, DPD1, LAP, Camurati-Engelmann Disease, Latency-associated peptide

NM_001003309.1

NP_001003309

P54831

Dog

Store as indicated in product manual.

Multifunctional protein that controls proliferation, differentiation and other functions in many cell types. Many cells synthesize TGFB1 and have specific receptors for it. It positively and negatively regulates many other growth factors. It plays an important role in bone remodeling as it is a potent stimulator of osteoblastic bone formation, causing chemotaxis, proliferation and differentiation in committed osteoblasts. Can promote either T-helper 17 cells (Th17) or regulatory T-cells (Treg) lineage differentiation in a concentration-dependent manner. At high concentrations, leads to FOXP3-mediated suppression of RORC and down-regulation of IL-17 expression, favoring Treg cell development. At low concentrations in concert with IL-6 and IL-21, leads to expression of the IL-17 and IL-23 receptors, favoring differentiation to Th17 cells. Mediates SMAD2/3 activation by inducing its phosphorylation and subsequent translocation to the nucleus. Can induce epithelial-to-mesenchymal transition (EMT) and cell migration in various cell types.By similarity p>Manually curated information which has been propagated from a related experimentally characterized protein. /p> a href="/manual/evidences#ECO:25">More… /a> /p> Manual assertion inferred from sequence similarity toiUniProtKB:P1137 (TGFB1_HUMAN)UniProtKB:P422 (TGFB1_MOUSE)

ELISA

Assay Methodology: Quantitative Sandwich Immunoassay

< 5.6 pg/mL

This assay has high sensitivity and excellent specificity for detection of Transforming Growth Factor Beta 1 (TGFb1). No significant cross-reactivity or interference between Transforming Growth Factor Beta 1 (TGFb1) and analogues was observed.

Wet Ice

4C