AGRN ELISA Kit (Mouse) (OKCA02331) | Aviva Systems Biology OKCA02331 product information

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product summary

company name :

Aviva Systems Biology

product type :

ELISA/assay

product name :

AGRN ELISA Kit (Mouse) (OKCA02331)

catalog :

OKCA02331

quantity :

96 Wells

product information

sku :

OKCA02331

product type :

Application Kit

category :

ELISA Kits

name :

AGRN ELISA Kit (Mouse) (OKCA02331)

size :

96 Wells

gene symbol :

AGRN

alias symbols :

RP11-54O7.13, FLJ45064, agrin proteoglycan

nucleotide accession num :

XM_011250177

protein accession num :

XP_011248479

swissprot id :

A2ASQ1

species reactivity :

Mouse

reconstitution and storage :

Store as indicated in product manual.

description of target :

Isoform 1: heparan sulfate basal lamina glycoprotein that plays a central role in the formation and the maintenance of the neuromuscular junction (NMJ) and directs key events in postsynaptic differentiation. This neuron-specific (z+) isoform is a component of the AGRN-LRP4 receptor complex that induces the phosphorylation and activation of MUSK. The activation of MUSK in myotubes induces the formation of NMJ by regulating different processes including the transcription of specific genes and the clustering of AChR in the postsynaptic membrane. Calcium ions are required for maximal AChR clustering. AGRN function in neurons is highly regulated by alternative splicing, glycan binding and proteolytic processing. Modulates calcium ion homeostasis in neurons, specifically by inducing an increase in cytoplasmic calcium ions. Functions differentially in the central nervous system (CNS) by inhibiting the alpha(3)-subtype of Na+/K+-ATPase and evoking depolarization at CNS synapses. This transmembrane agrin (TM-agrin) isoform, the predominate form in neurons of the brain, induces dendritic filopodia and synapse formation in mature hippocampal neurons in large part due to the attached glycosaminoglycan chains and the action of Rho-family GTPases. Isoform 2 and isoform 3: these isoforms lacking the 'z' insert (z) are muscle-specific, have no AChR clustering ability and may be involved in nervous system endothelial cell differentiation. Agrin N-terminal 11 kDa subunit: involved in regulation of neurite outgrowth probably due to the presence of the glycosaminoglcan (GAG) side chains of heparan and chondroitin sulfate attached to the Ser/Thr- and Gly/Ser-rich regions. Also involved in modulation of growth factor signaling.

assay info :

Assay Methodology: Quantitative Sandwich Immunoassay

sensitivity :

0.078 ng/mL

drywet surcharge :

Wet Ice

storage temperature :

2-8C