ELISA/assay

S100B ELISA Kit (Human) : 96 Wells (OKCA00128)

OKCA00128

96 Wells

Application Kit

ELISA Kits

S100B ELISA Kit (Human) : 96 Wells (OKCA00128)

96 Wells

S100B

NEF, Protein S100-B, S100, S100-B, S100beta, S100 calcium-binding protein B, S-100 protein beta chain, S-100 protein subunit beta

NM_006272

NP_006263

P04271

Human

Store as indicated in product manual.

The protein encoded by this gene is a member of the S1 family of proteins containing 2 EF-hand calcium-binding motifs. S1 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S1 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes.

Assay Methodology: Quantitative Sandwich Immunoassay

< 19.5 ng/mL

This assay employs the quantitative sandwich enzyme immunoassay technique. This assay has high sensitivity and excellent specificity for detection of human S-100B. No significant cross-reactivity or interference between human S-100B and analogues was observed.

Wet Ice

4C