ELISA/assay

Complement C5a ELISA Kit (Human) (OKBB00646)

OKBB00646

96 Wells

Application Kit

ELISA Kits

Complement C5a ELISA Kit (Human) (OKBB00646)

96 Wells

C5

C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4, Complement C5, CPAMD4, FLJ17816, FLJ17822, MGC142298

NM_001735.2

NP_001726.2

P01031

Human

Store as indicated in product manual.

C5a is a protein fragment released from complement component C5. This gene is mapped to 9q33.2. The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components. Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections. Defects in this gene have also been linked to susceptibility to liver fibrosis and to rheumatoid arthritis.

ELISA

Assay Methodology: Quantitative Sandwich Immunoassay

<= 10 pg/mL

Wet Ice

4C