ELISA/assay

TGFI ELISA Kit (Human) (OKBB00252)

OKBB00252

96 Tests

Application Kit

ELISA Kits

TGFI ELISA Kit (Human) (OKBB00252)

96 Tests

TGFA

Transforming growth factor alpha, EGF-like TGF, TGF type 1

NM_001099691.2

NP_001093161.1

P01135

Human

Store as indicated in product manual.

Transforming growth factor alpha (TGF-alpha) is upregulated in some human cancers. It is produced in macrophages, brain cells, and keratinocytes, and induces epithelial development. It is closely related to EGF, and can also bind to the EGF receptor with similar effects . TGFalpha stimulates neural cell proliferation in the adult injured brain.1 Transforming growth factor alpha gene (TGFA) maps to human chromosome 2 close to the breakpoint of the t(2;8) variant translocation in Burkitt lymphoma.2 Synthetic TGF-alpha was as active as murine epidermal growth factor in binding to the epidermal growth factor receptor and in stimulation of anchorage-dependent and of anchorage-independent growth of normal indicator cells in culture. Synthetic TGF-alpha stimulated plasminogen activator production in A 431 and HeLa cells; the stimulation was similar to that induced by epidermal growth factor. Furthermore, synthetic human TGF-alpha showed similar immunoreactivity when compared with rat TGF-alpha. Thus, the 5-amino acid TGF-alpha is likely to be the bioactive principle produced and secreted by tumor cell lines.3

ELISA

Cross-reactivates with TGFbeta2, TGFbeta3, TGFbeta5 <1%.

< 1 pg/mL

There is cross-reactivates with TGF beta 2, TGF beta 3, TGF beta 5 < 1%.

Wet Ice

4C