MMP-2 ELISA Kit (Human) (OKBB00220) | Aviva Systems Biology OKBB00220 product information

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product summary

company name :

Aviva Systems Biology

product type :

ELISA/assay

product name :

MMP-2 ELISA Kit (Human) (OKBB00220)

catalog :

OKBB00220

quantity :

96 Tests

product information

sku :

OKBB00220

product type :

Application Kit

category :

ELISA Kits

name :

MMP-2 ELISA Kit (Human) (OKBB00220)

size :

96 Tests

gene symbol :

MMP2

alias symbols :

CLG4, MONA, CLG4A, MMP-2, TBE-1, MMP-II

nucleotide accession num :

NM_001127891.2

protein accession num :

NP_001121363.1

swissprot id :

P08253

species reactivity :

Human

reconstitution and storage :

Store as indicated in product manual.

description of target :

Type IV collagenase, 72-kD, is officially designated matrix metalloproteinase-2 (MMP2). It is also known as gelatinase, 72-kD. MMP-2 plays an essential role in angiogenesis and arteriogenesis, two processes critical to restoration of tissue perfusion after ischemia. MMP-2 expression is increased in tissue ischemia, but the responsible mechanisms remain unknown.1 Matrix metalloproteinases (MMPs) catalyze extracellular matrix degradation. Control of their activity is a promising target for therapy of diseases characterized by abnormal connective tissue turnover. MMPs are expressed as latent proenzymes that are activated by proteolytic cleavage that triggers a conformational change in the propeptide (cysteine switch). The structure of proMMP-2 reveals how the propeptide shields the catalytic cleft and that the cysteine switch may operate through cleavage of loops essential for propeptide stability.2 The gene is localized to 16q21 using somatic cell hybrids and in situ hybridization.3 The standard product used in this kit is recombinant human MMP-2, consisting of 631 amino acids with the molecular mass of 71KDa. The detected MMP-2 includes zymogen and active enzyme.

application :

ELISA

sensitivity :

< 10 pg/mL

specificity :

Natural and recombinant human total MMP-2. There is no detectable cross-reactivity with other relevant proteins.

drywet surcharge :

Wet Ice

storage temperature :