IL1B ELISA Kit (Human) (OKBB00176) | Aviva Systems Biology OKBB00176 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Aviva Systems Biology

product type :

ELISA/assay

product name :

IL1B ELISA Kit (Human) (OKBB00176)

catalog :

OKBB00176

quantity :

96 Tests

product information

sku :

OKBB00176

product type :

Application Kit

category :

ELISA Kits

name :

IL1B ELISA Kit (Human) (OKBB00176)

size :

96 Tests

gene symbol :

IL1B

alias symbols :

IL-1I, Interleukin-1b, Interleukin-1I, Interleukin-1 beta, IL1B

nucleotide accession num :

NM_000576.2

protein accession num :

NP_000567.1

swissprot id :

P01584

species reactivity :

Human

reconstitution and storage :

Store as indicated in product manual.

description of target :

Interleukin-1beta ( IL-1beta) is a potent stimulator of bone resorption whose gene is mapped to 2q14, and has been implicated in the pathogenesis of high bone turnover and osteoporosis. IL-1beta, a prominent microglia-derived cytokine, caused oligodendrocyte death in coculture with astrocytes and microglia, but not in pure culture of oligodendrocytes alone1. It also can cause nuclear export of a specific NCOR corepressor complex, resulting in derepression of a specific subset of nuclear factor-kappa-B (NFKB)-regulated genes2. Furthermore, Microenvironmental IL-1beta and, to a lesser extent, IL-1alpha are required for in vivo angiogenesis and invasiveness of different tumor cells3. Additional, the cooperation of IL-1beta and PDGFB induces contractile-to-synthetic phenotype modulation of human aortic smooth muscle cells in culture4. Moreover, the association with disease may be explained by the biologic properties of IL-1beta, which is an important proinflammatory cytokine and a powerful inhibitor of gastric acid secretion5.

application :

ELISA

homology :

No detectable cross-reactivity with any other cytokine.

sensitivity :

< 0.15 pg/ml

specificity :

There is no detectable cross-reactivity with other relevant proteins.

drywet surcharge :

Wet Ice

storage temperature :