ELISA/assay

FAS ELISA Kit (Human) (OKBB00141)

OKBB00141

96 Tests

Application Kit

ELISA Kits

FAS ELISA Kit (Human) (OKBB00141)

96 Tests

FAS

FAS, APT1, FAS1, TNFRSF6, Tumor necrosis factor receptor superfamily member 6, APO1, APO1 cell surface antigen

NM_000043.5

NP_000034.1

P25445

Human

Store as indicated in product manual.

Fas, also known as APO-1, CD95 and TNFRSF6, is a member of the nerve growth factor (NGF)/tumour necrosis factor (TNF) receptor superfamily and mediates apoptosis.1 The nucleotide sequence of the cDNAs reveales that the molecule coding for the Fas antigen determinant is a 319 amino acid polypeptide with a single transmembrane domain. The extracellular domain is rich in cysteine residue, and shows a similarity to that of human tumor necrosis factor receptors, human nerve growth factor receptor, and human B cell antigen CD4.2 The APO-1 antigen as defined by the mouse monoclonal antibody anti-APO-1 is previously found to be expressed on the cell surface of activated human T and B lymphocytes and a variety of malignant human lymphoid cell lines. The APO-1 antigen is found to be a membrane glycoprotein of 48-kDa.3 Fas antigen is expressed and functional on papillary thyroid cancer cells and this may have potential therapeutic significance.4 Fas can play a role as an inducer of both neurite growth in vitro and accelerates recovery after nerve injury in vivo.5 The FAS and FASL triggered apoptosis pathway plays an important role in human carcinogenesis.6

ELISA

No detectable cross-reactivity with any other cytokine

< 3 pg/ml

There is no detectable cross-reactivity with other relevant proteins.

Wet Ice

4C