ELISA/assay

Androgen Receptor DNA-Binding ELISA Kit (OKAG00363)

OKAG00363

96 Tests

Application Kit

ELISA Kits

Androgen Receptor DNA-Binding ELISA Kit (OKAG00363)

96 Tests

AR

AIS, Androgen receptor, DHTR, Dihydrotestosterone receptor, HUMARA, HYSP1, KD, NR3C4, Nuclear receptor subfamily 3 group C member 4, SBMA, SMAX1, TFM

P10275

Human, Mouse, Rat

12 x 8-Well Microstrips

Store as indicated in product manual.

The androgen receptor gene is more than 9 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract causes spinal bulbar muscular atrophy (Kennedy disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Two alternatively spliced variants encoding distinct isoforms have been described.

ELISA

Assay Type: Qualitative DNA Binding ELISA

The Androgen Receptor DNA-Binding ELISA Kit detects endogenous levels of total Androgen Receptor protein.

Wet Ice

4C