ELISA/assay

Pro-Cathepsin B ELISA Kit (Human) : 96 Wells (OKAG00242)

OKAG00242

96 Wells

Application Kit

ELISA Kits

Pro-Cathepsin B ELISA Kit (Human) : 96 Wells (OKAG00242)

96 Wells

CTSB

APPS, APP secretase, Cathepsin B, Cathepsin B1, CPSB

NM_001908.4

NP_001899.1

P07858

Human

1 x 96-Well Plate or 12 x 8-Well Strips

Store as indicated in product manual.

This gene encodes a member of the C1 family of peptidases. Alternative splicing of this gene results in multiple transcript variants. At least one of these variants encodes a preproprotein that is proteolytically processed to generate multiple protein products. These products include the cathepsin B light and heavy chains, which can dimerize to form the double chain form of the enzyme. This enzyme is a lysosomal cysteine protease with both endopeptidase and exopeptidase activity that may play a role in protein turnover. It is also known as amyloid precursor protein secretase and is involved in the proteolytic processing of amyloid precursor protein (APP). Incomplete proteolytic processing of APP has been suggested to be a causative factor in Alzheimer s disease, the most common cause of dementia. Overexpression of the encoded protein has been associated with esophageal adenocarcinoma and other tumors. Multiple pseudogenes of this gene have been identified.

ELISA

Quantitative Colorimentric Sandwich ELISA

250 pg/mL

The Human Pro-Cathepsin B ELISA is capable of recognizing both recombinant and naturally produced Human Pro-Cathepsin B proteins. The antigens listed below were tested at 160 ng/ml and did not exhibit significant cross reactivity or interference.• Human: Cathepsin A, Cathepsin C, Cathepsin D, Cathepsin E, Cathepsin L, Cathepsin S, Cathepsin V, Cathepsin X/Z/P, Cystatin C, Cystatin D, Cystatin SA• Murine: Cathepsin B

Wet Ice

4C