VEGFA ELISA Kit (Human) : 48 Wells (OKAA00029-48W) | Aviva Systems Biology OKAA00029 product information

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product summary

company name :

Aviva Systems Biology

product type :

ELISA/assay

product name :

VEGFA ELISA Kit (Human) : 48 Wells (OKAA00029-48W)

catalog :

OKAA00029

quantity :

48 Wells

product information

sku :

OKAA00029

product type :

Application Kit

category :

ELISA Kits

name :

VEGFA ELISA Kit (Human) : 48 Wells (OKAA00029-48W)

size :

48 Wells

gene symbol :

VEGFA

alias symbols :

MGC70609, MVCD1, Vascular endothelial growth factor A, Vascular permeability factor, VEGF, VEGF-A, VPF

nucleotide accession num :

NM_001025366.2

protein accession num :

NP_001020537.2

swissprot id :

P15692

species reactivity :

Human

description of target :

This gene is a member of the PDGF/VEGF growth factor family. It encodes a heparin-binding protein, which exists as a disulfide-linked homodimer. This growth factor induces proliferation and migration of vascular endothelial cells, and is essential for both physiological and pathological angiogenesis. Disruption of this gene in mice resulted in abnormal embryonic blood vessel formation. This gene is upregulated in many known tumors and its expression is correlated with tumor stage and progression. Elevated levels of this protein are found in patients with POEMS syndrome, also known as Crow-Fukase syndrome. Allelic variants of this gene have been associated with microvascular complications of diabetes 1 (MVCD1) and atherosclerosis. Alternatively spliced transcript variants encoding different isoforms have been described. There is also evidence for alternative translation initiation from upstream non-AUG (CUG) codons resulting in additional isoforms. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is antiangiogenic. Expression of some isoforms derived from the AUG start codon is regulated by a small upstream open reading frame, which is located within an internal ribosome entry site.

application :

ELISA

homology :

Human

assay info :

Assay Method: Quantitative Sandwich ELISA

sensitivity :

7 pg/ml

specificity :

This assay recognizes both natural and recombinant human TSLP. The factors listed below were prepared at 50ng/ml in Standard /sample Diluent and assayed for cross-reactivity and no significant cross-reactivity or interference was observed.Recombinant human: IL-1a, IL-1b, IL-2, IL-3, IL-4, IL-5, IL-6 , Recombinant mouse: IL-1a, IL-1b, IL-2, IL-4, IL-5, IL-6 , Recombinant rat: IL-1a , IL-1b, IL-2, IL-4, IL-6, IL-10, Leptin ,

drywet surcharge :

Wet Ice

storage temperature :