ELISA/assay

FAS ELISA Kit (Human) : 48 Wells (OKAA00002-48W)

OKAA00002

48 Wells

Application Kit

ELISA Kits

FAS ELISA Kit (Human) : 48 Wells (OKAA00002-48W)

48 Wells

FAS

ALPS1A, APO-1, Apo-1 antigen, Apoptosis-mediating surface antigen FAS, APT1, CD95, FAS1, FASLG receptor, FASTM, TNFRSF6, Tumor necrosis factor receptor superfamily member 6

NM_000043.5

NP_000034.1

P25445

Human

The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains a death domain. It has been shown to play a central role in the physiological regulation of programmed cell death, and has been implicated in the pathogenesis of various malignancies and diseases of the immune system. The interaction of this receptor with its ligand allows the formation of a death-inducing signaling complex that includes Fas-associated death domain protein (FADD), caspase 8, and caspase 1. The autoproteolytic processing of the caspases in the complex triggers a downstream caspase cascade, and leads to apoptosis. This receptor has been also shown to activate NF-kappaB, MAPK3/ERK1, and MAPK8/JNK, and is found to be involved in transducing the proliferating signals in normal diploid fibroblast and T cells. Several alternatively spliced transcript variants have been described, some of which are candidates for nonsense-mediated mRNA decay (NMD). The isoforms lacking the transmembrane domain may negatively regulate the apoptosis mediated by the full length isoform.

ELISA

Human

Assay Method: Quantitative Sandwich ELISA

31 pg/ml

This assay recognizes both natural and recombinant human APO-1/FAS. The factors listed below were prepared at 50ng/ml in Standard /sample Diluent and assayed for cross-reactivity and no significant cross-reactivity or interference was observed.Recombinant human: G-CSF, GM-CSF, IL-1a, IL-1b, IL-2 Recombinant mouse: GM-CSF, TNF-a, MIP-1a, GM-CSF Other proteins: b FGF acidic, b FGF basic, h PDGF, p PDGF, h TGF-b1

Wet Ice

4C