OLR1 Polyclonal Antibody (OABB00784) | Aviva Systems Biology OABB00784 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Aviva Systems Biology

product type :

antibody

product name :

OLR1 Polyclonal Antibody (OABB00784)

catalog :

OABB00784

quantity :

100 ug

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, rat

application :

western blot

product information

sku :

OABB00784

product type :

Polyclonal Antibody

category :

Polyclonal

name :

OLR1 Polyclonal Antibody (OABB00784)

size :

100 ug

gene symbol :

OLR1

alias symbols :

LOX1, LOXIN, SLOX1, CLEC8A, SCARE1,

swissprot id :

P78380

species reactivity :

Human, Rat

product format :

Lyophilized. Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4, 0.05mg Thimerosal, 0.05mg NaN3

reconstitution and storage :

Reconstitution: 0.2ml of distilled water will yield a concentration of 500ug/ml.Storage: At -20 C for one year. After reconstitution, at 4 C for one month. It can also be aliquoted and stored frozen at -20 C for a longer time. Avoid repeated freezing and thawing.

description of target :

OLR1 (oxidized low density lipoprotein (lectin-like) receptor 1) also called CLEC8A, LOX-1, SCARE1, is a receptor protein which belongs to the C-type lectin superfamily. The OLR1 gene encodes a cell-surface endocytosis receptor for oxidized low density lipoprotein (OxLDL).The OLR1 gene is mapped on 12p13.2. Incubation of the cells with LDL had no effect on LOX1 expression, but incubation with OxLDL resulted in a dose-dependent increase in LOX1 mRNA and protein expression; however, very high concentrations of OxLDL caused a decrease in OxLDL expression, perhaps indicating toxic effects on endothelial cells. LOX1 was also expressed in macrophages, but not in vascular smooth muscle cells. The findings suggested a role for LOX1 in the pathophysiology of atherosclerotic cardiovascular disease.LOX1 expression was detected in all choroidal neovascular membranes, regardless of structure, whereas there was no evidence of LOX1 within the posterior segments of normal eyes. LOX1 plays an active role in the pathogenesis of choroidal neovascularization, especially in ARMD.

host :

Rabbit

application :

purification :

Immunogen affinity purified.

clonality :

Polyclonal

specificity :

No cross reactivity with other proteins.

immunogen :

A synthetic peptide corresponding to a sequence in the middle region of human OLR1 (114-127aa NEKSKEQMELHHQN), different from the related rat sequence by three amino acids.

application info :

Western Blot: 0.1-0.5 ug/ml; Tested Species: Human, Rat

drywet surcharge :

Room Temperature

storage temperature :

-20C