HAVCR1 Antibody (OABB00585) | Aviva Systems Biology OABB00585 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Aviva Systems Biology

product type :

antibody

product name :

HAVCR1 Antibody (OABB00585)

catalog :

OABB00585

quantity :

100 ug

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunohistochemistry - paraffin section, immunohistochemistry - frozen section

product information

sku :

OABB00585

product type :

Polyclonal Antibody

category :

Polyclonal

name :

HAVCR1 Antibody (OABB00585)

size :

100 ug

gene symbol :

HAVCR1

nucleotide accession num :

NM_001173393.2

protein accession num :

NP_001166864.1

swissprot id :

Q96D42

species reactivity :

Rat

product format :

Lyophilized

reconstitution and storage :

Reconstitution: 0.2ml of distilled water will yield a concentration of 500ug/ml.Storage: At -20C for one year. After reconstitution, at 4C for one month. It canalso be aliquotted and stored frozen at -20C for a longer time. Avoid repeated freezing and thawing

description of target :

KIM1(KIDNEY INJURY MOLECULE 1), also known as HAVCR1, HAVCR or TIM1, is a protein that in humans is encoded by the KIM1 gene. The KIM1 gene is mapped to 5q33.3. Biochemical, mutational, and cell adhesion analyses confirm that Tim1 is capable of homophilic Tim-Tim interactions. The features identified in murine KIM1 is conserved in human KIM1. The KIM1 protein is indeed a receptor for the virus through the infection of canine osteogenic sarcoma cells expressing HAVCR1 with HAV. Using a monoclonal antibody to mouse Tim1, Tim1 is expressed after activation of naive T cells and on T cells differentiated in Th2-polarizing conditions. Ectopic expression of KIM1 during mouse T-cell differentiation leads to production of the Th2-type cytokine Il4, but not the Th1-type cytokine Ifng. KIM1-expressing epithelial cells internalized apoptotic bodies, and Kim1 is directly responsible for phagocytosis in cultured primary rat tubule epithelial cells and in porcine and canine epithelial cell lines.

host :

Rabbit

application :

WB, IHC-P, IHC-F

homology :

Rat

purification :

Immunogen affinity purified.

clonality :

Polyclonal

immunogen :

A synthetic peptide corresponding to a sequence at the C-terminal of rat KIM1(289-307aa HPRAEDNIYIIEDRSRGAE).

application info :

Western blot: 0.1-0.5ug/ml - Rat Immunohistochemistry (Paraffin-embedded Section): 0.5-1ug/ml - Rat - By Heat By Heat: Boiling the paraffin sections in 10mM citrate buffer, pH6.0, for 20mins is required for the staining offormalin/paraffin sections. Immunohistochemistry (Frozen Section): 0.5-1ug/ml - Rat Other applications have not been tested.Optimal dilutions should be determined by end users.

drywet surcharge :

Room Temperature

storage temperature :

-20C