FOLH1 Antibody - N-terminal region (OAAB10007) | Aviva Systems Biology OAAB10007 product information

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product summary

company name :

Aviva Systems Biology

product type :

antibody

product name :

FOLH1 Antibody - N-terminal region (OAAB10007)

catalog :

OAAB10007

quantity :

400 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human

application :

western blot, immunocytochemistry, immunohistochemistry - paraffin section

product information

sku :

OAAB10007

product type :

Polyclonal Antibody

category :

Polyclonal

name :

FOLH1 Antibody - N-terminal region (OAAB10007)

size :

400 ul

gene symbol :

FOLH1

alias symbols :

FOLH1, FOLH, NAALAD1, PSM, PSMA, Glutamate carboxypeptidase 2, Cell growth-inhibiting gene 27 protein, Folate hydrolase 1, Folylpoly-gamma-glutamate carboxypeptidase, Glutamate carboxypeptidase II, Membrane glutamate carboxypeptidase, N-acetyla

protein accession num :

NP_001014986.1

swissprot id :

Q04609

species reactivity :

Human

product format :

Liquid. PBS with 0.09% (W/V) sodium azide.

reconstitution and storage :

Maintain refrigerated at 2-8 C for up to 2 weeks. For long term storage store at -20 C in small aliquots to prevent freeze-thaw cycles.

description of target :

This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms.

host :

Rabbit

application :

WB, IHC-P, IF

homology :

Human; Mouse; Pig; Rat

purification :

This antibody is purified through a protein A column, followed by peptide affinity purification.

clonality :

Polyclonal

immunogen :

This FOLH1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 161-190 amino acids from the N-terminal region of human FOLH1.

application info :

WB 1:1000 IHC-P 1:10~50 IF 1:10~50

drywet surcharge :

Wet Ice

storage temperature :

-20C