DTL Antibody - middle region (OAAB00993) | Aviva Systems Biology OAAB00993 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Aviva Systems Biology

product type :

antibody

product name :

DTL Antibody - middle region (OAAB00993)

catalog :

OAAB00993

quantity :

400 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, mouse

application :

western blot, flow cytometry

product information

sku :

OAAB00993

product type :

Polyclonal Antibody

category :

Polyclonal

name :

DTL Antibody - middle region (OAAB00993)

size :

400 ul

gene symbol :

DTL

alias symbols :

Denticleless protein homolog, DTL, CDT2, CDW1, DCAF2, L2DTL, RAMP

protein accession num :

NP_057532.2

swissprot id :

Q9NZJ0

species reactivity :

Human, Mouse

product format :

Liquid. PBS with 0.09% (W/V) sodium azide.

reconstitution and storage :

Maintain refrigerated at 2-8 C for up to 2 weeks. For long term storage store at -20 C in small aliquots to prevent freeze-thaw cycles.

description of target :

Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1 and CDKN1A/p21(CIP1). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. Most substrates require their interaction with PCNA for their polyubiquitination: substrates interact with PCNA via their PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis.

host :

Rabbit

application :

WB, FC

purification :

This antibody is purified through a protein A column, followed by peptide affinity purification.

clonality :

Polyclonal

immunogen :

This DTL antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 229-256 amino acids from the Central region of human DTL.

application info :

WB: 1:1000FC: 1:10~50

drywet surcharge :

Wet Ice

storage temperature :

-20C