MDM4 antibody - N-terminal region (AVARP06007_P050) | Aviva Systems Biology AVARP06007 product information

This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.

product summary

company name :

Aviva Systems Biology

product type :

antibody

product name :

MDM4 antibody - N-terminal region (AVARP06007_P050)

catalog :

AVARP06007

quantity :

100 ul

clonality :

polyclonal

host :

domestic rabbit

conjugate :

nonconjugated

reactivity :

human, dogs, bovine

application :

western blot

product information

sku :

AVARP06007

product type :

Polyclonal Antibody

category :

Polyclonal

name :

MDM4 antibody - N-terminal region (AVARP06007_P050)

size :

100 ul

gene symbol :

MDM4

alias symbols :

DKFZp781B1423, MDMX, MGC132766, MRP1, HDMX

nucleotide accession num :

NM_002393

protein accession num :

NP_002384

swissprot id :

O15151

species reactivity :

Cow, Dog, Horse, Human, Pig, Rabbit

product format :

Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.

peptide sequence :

IPSQDQLKQSAEESSTSRKRTTEDDIPTLPTSEHKCIHS
REDEDLIENLA
Synthetic peptide located within the following region:

reconstitution and storage :

For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.

description of target :

MDM4 inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. It inhibits degradation of MDM2. It can reverse MDM2-targeted degradation of p53 while maintaining suppression of p53 transactivation and apoptotic functions. The human MDM4 gene, which plays a role in apoptosis, encodes a 49-amino acid protein containing a RING finger domain and a putative nuclear localization signal. The MDM4 putative nuclear localization signal, which all Mdm proteins contain, is located in the C-terminal region of the protein. The mRNA is expressed at a high level in thymus and at lower levels in all other tissues tested. MDM4 protein produced by in vitro translation interacts with p53 via a binding domain located in the N-terminal region of the MDM4 protein. MDM4 shows significant structural similarity to p53-binding protein MDM2. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

host :

Rabbit

application :

homology :

Cow: 80%; Dog: 93%; Horse: 93%; Human: 100%; Pig: 86%; Rabbit: 80%

purification :

Affinity Purified

clonality :

Polyclonal

immunogen :

The immunogen is a synthetic peptide directed towards the N terminal region of human MDM4

drywet surcharge :

Wet Ice

storage temperature :

-20C